N-phenethyl-heptanamide | 251350-20-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-phenethyl-heptanamide
• 英文别名: N-phenethylheptanamide；N-phenethyl-heptanamide；N-Phenaethyl-heptanamid；N-(2-phenylethyl)heptanamide
• CAS: 251350-20-6
• 化学式: C₁₅H₂₃NO
• 分子量: 233.354
• InChiKey: ALMLWHIDDYXCIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-phenethyl-heptanamide 在 1,4-二氧六环 、 copper oxide-chromium oxide 作用下， 250.0 ℃ 、29.42 MPa 条件下， 生成 庚基-苯乙基-胺
  参考文献：
  名称：

  Catalytic Hydrogenation of Amides to Amines

  摘要：

  DOI：

  10.1021/ja01326a061
• 作为产物：
  描述：

  乙基溴苯 在 sodium azide 、 三氟甲磺酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.17h， 生成 N-phenethyl-heptanamide
  参考文献：
  名称：

  烷基叠氮化物与酰基硅烷的分子间Schmidt反应

  摘要：

  已经设计并实现了烷基叠氮化物与酰基硅烷的第一个分子间Schmidt反应，从而生产出一系列具有绝对位点选择性的酰胺，而且产率高至优异。已经提出了转化机理，并且该反应显示了底物的范围。

  DOI：

  10.1016/j.tetlet.2016.06.124

文献信息

• Direct oxidative amidation of aldehydes with amines catalyzed by heteropolyanion-based ionic liquids under solvent-free conditions via a dual-catalysis process
  作者：Renzhong Fu、Yang Yang、Jin Zhang、Jintao Shao、Xuming Xia、Yunsheng Ma、Rongxin Yuan

  DOI：10.1039/c5ob02376a

  日期：——

  A simple and efficient procedure for the synthesis of amides directly from aldehydes and amines catalyzed by heteropolyanion-based ionic liquids under solvent-free conditions has been reported. The practical protocol was found to tolerate a wide range of substrates with different functional groups. Moderate to excellent yields, solvent-free media, and operational simplicity are the main highlights

  已经报道了一种简单有效的方法，可在无溶剂条件下直接由杂多阴离子型离子液体催化的醛和胺直接合成酰胺。发现该实用方案可耐受具有不同官能团的多种底物。主要亮点是中等至出色的产量，无溶剂介质和操作简便。简要研究了所提出的双重催化机理。此外，基于杂多阴离子的离子液体易于用于该氧化酰胺化。
• An efficient, eco-friendly and sustainable tandem oxidative amidation of alcohols with amines catalyzed by heteropolyanion-based ionic liquids via a bifunctional catalysis process
  作者：Renzhong Fu、Yang Yang、Wei Feng、Qiuxia Ge、Yan Feng、Xiaojun Zeng、Wen Chai、Jun Yi、Rongxin Yuan

  DOI：10.1016/j.tet.2016.11.002

  日期：2016.12

  eco-friendly and sustainable method for the tandem oxidative amidation of alcohols with amines has been reported. Using heteropolyanion-based ionic liquids as the catalyst and tert-butyl hydroperoxide as the oxidant, this amidation reaction is operationally straightforward and provides a series of primary, secondary and tertiary amides derivatives in moderate to good yields. Solvent-free media, microwave-promoted

  已经报道了一种有效的，生态友好的和可持续的方法，用于醇与胺的串联氧化酰胺化。使用基于杂多阴离子的离子液体作为催化剂，使用叔丁基氢过氧化物作为氧化剂，该酰胺化反应操作简单，并以中等至良好的产率提供了一系列伯，仲和叔酰胺衍生物。无溶剂介质，微波促进条件和催化剂的可重复使用性是主要亮点。此外，在本报告中已对所提出的双功能催化机理进行了简要研究。
• [EN] NOVEL CYANOGUANIDINES<br/>[FR] NOUVELLES CYANOGUANIDINES
  申请人：TOPOTARGET AS

  公开号：WO2009086835A1

  公开（公告）日：2009-07-16

  This application discloses novel cyanoguanidines of the formula (I) wherein A is selected from -C(=O)-, -S(=O)2-, -C(=S)-, and -P(=O)(R5)-, wherein R5 is selected from C1-6-alkyl, C1-6-alkoxy, and hydroxy; B is selected from a single bond, -O-, -NR6- and -C(=O)-NR6-, wherein R6 is selected from hydrogen, optionally substituted C1-12-alkyl, optionally substituted C1-12-alkenyl, optionally substituted aryl, optionally substituted heterocyclyl, and optionally substituted heteroaryl; and m is an integer of 0-12 and n is an integer of 0-12, wherein the sum m+n is 1-20; and R1 is selected from optionally substituted heteroaryl; and pharmaceutically acceptable salts thereof, and prodrugs thereof. The compounds are usefuld for use as a medicament for the treatment of a disease or a condition caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPRT).

  该申请公开了一种新型氰胍啶化合物，其化学式为（I），其中A从-C（=O）-，-S（=O）2-，-C（=S）-和-P（=O）（R5）-中选择，其中R5选择自C1-6-烷基，C1-6-烷氧基和羟基；B从单键，-O-，-NR6-和-C（=O）-NR6-中选择，其中R6选择自氢，可选择地取代的C1-12-烷基，可选择地取代的C1-12-烯基，可选择地取代的芳基，可选择地取代的杂环烷基和可选择地取代的杂环芳基；m为0-12的整数，n为0-12的整数，其中m+n之和为1-20；R1选择自可选择地取代的杂环芳基；以及其药学上可接受的盐和前药。这些化合物可用作治疗由烟酰胺磷酸核糖转移酶（NAMPRT）水平升高引起的疾病或病况的药物。
• ANTHELMINTIC AGENTS AND THEIR USE
  申请人：Chassaing Christophe Pierre Alain

  公开号：US20110319393A1

  公开（公告）日：2011-12-29

  This invention is directed to compounds and salts that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents. This invention also is directed to processes for making the compounds and salts, pharmaceutical compositions and kits comprising the compounds and salts, uses of the compounds and salts to make medicaments, and treatments comprising the administration of the compounds and salts to animals in need of the treatments.

  本发明涉及化合物和盐，通常可用作驱虫剂或作为制备驱虫剂的中间体。本发明还涉及制备这些化合物和盐的过程，包括这些化合物和盐的药物组合物和试剂盒，使用这些化合物和盐制备药物，并将这些化合物和盐用于治疗需要治疗的动物的治疗方法。
• Solid-Supported Chloro[1,3,5]triazine. A Versatile New Synthetic Auxiliary for the Synthesis of Amide Libraries
  作者：Simonetta Masala、Maurizio Taddei

  DOI：10.1021/ol990215h

  日期：1999.11.1

  [GRAPHICS]2,4,6-Trichloro[1,3,5]triazine was loaded on different types of NH2-functional resins to give a new supported reagent. The best results, in term of yields products, were obtained using the chlorotriazine linked to a polystyrene-poly(ethylene glycol) resin. This reagent was employed for the solution-phase synthesis of different amides and dipeptides.