1-Phenyl-2,3-dimethyl-4-dimethylamino-3-pyrazolin-5-thion | 26673-77-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-Phenyl-2,3-dimethyl-4-dimethylamino-3-pyrazolin-5-thion
• 英文别名: Thiopyramidon；4-dimethylamino-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazole-3-thione；4-Dimethylamino-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-thion；4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazole-3-thione；4-(dimethylamino)-1,5-dimethyl-2-phenylpyrazole-3-thione
• CAS: 26673-77-8
• 化学式: C₁₃H₁₇N₃S
• 分子量: 247.364
• InChiKey: IQOPHAVDJCXOGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  41.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydrogensulfide 、 水 作用下， 生成 1-Phenyl-2,3-dimethyl-4-dimethylamino-3-pyrazolin-5-thion
  参考文献：
  名称：

  Michaelis; Stau, Chemische Berichte, 1913, vol. 46, p. 3612

  摘要：

  DOI：

文献信息

• SOLUBLE GUANYLATE CYCLASE ACTIVATORS
  申请人：Bittner Amy R.

  公开号：US20090209556A1

  公开（公告）日：2009-08-20

  A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris, thromboses, restenoses, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver in a human or animal patient.

  具有治疗或预防心血管疾病、内皮功能障碍、舒张功能障碍、动脉硬化、高血压、心绞痛、血栓形成、再狭窄、心肌梗死、中风、心脏衰竭、肺动脉高压、勃起功能障碍、支气管哮喘、慢性肾功能不全、糖尿病或人或动物患者肝硬化的化合物的结构。
• Soluble Guanylate Cyclase Activators
  申请人：Bittner Amy R.

  公开号：US20110118282A1

  公开（公告）日：2011-05-19

  A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris, thromboses, restenoses, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver in a human or animal patient.

  一种化合物具有结构，用于治疗或预防人或动物患者的心血管疾病、内皮功能障碍、舒张功能障碍、动脉粥样硬化、高血压、心绞痛、血栓、再狭窄、心肌梗死、中风、心脏功能不全、肺动脉高压、勃起功能障碍、支气管哮喘、慢性肾功能不全、糖尿病或肝硬化。
• US8455638B2
  申请人：——

  公开号：US8455638B2

  公开（公告）日：2013-06-04
• [EN] SOLUBLE GUANYLATE CYCLASE ACTIVATORS<br/>[FR] ACTIVATEURS DE LA GUANYLATE CYCLASE SOLUBLE
  申请人：MERCK & CO INC

  公开号：WO2009032249A1

  公开（公告）日：2009-03-12

  A compound having the structure I useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris, thromboses, restenoses, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver in a human or animal patient.