N-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)formamide | 1192814-78-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(2-(2-(1H-imidazol-4-yl)phenoxy)ethyl)formamide
• 英文别名: N-[2-[2-(1H-imidazol-5-yl)phenoxy]ethyl]formamide
• CAS: 1192814-78-0
• 化学式: C₁₂H₁₃N₃O₂
• 分子量: 231.254
• InChiKey: JGPNCKPKHMHERK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  67
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N,N-二甲基甲酰胺 、 2-氯嘧啶 、 2-(2-(1H-imidazol-5-yl)phenoxy)ethanamine 反应 18.0h， 以12%的产率得到N-(2-(2-(1H-imidazol-5-yl)phenoxy)ethyl)pyrimidin-2-amine
  参考文献：
  名称：

  IDO inhibitors

  摘要：

  目前提供的是按照化学式(I)或(II)提供的化合物以及含有这些化合物的药物组合物，其中R1、R4和R5在此有定义。这些化合物和组合物可用于调节吲哌醇胺2,3-二氧化酶的活性；治疗吲哌醇胺2,3-二氧化酶（IDO）介导的免疫抑制；治疗受益于抑制吲哌醇胺-2,3-二氧化酶酶活性的医疗状况；增强包括给予抗癌剂的抗癌治疗的有效性；治疗与癌症相关的肿瘤特异性免疫抑制；以及治疗与传染性疾病相关的免疫抑制。

  公开号：

  US09174942B2

文献信息

• IDO Inhibitors
  申请人：Mautino Mario R.

  公开号：US20110136796A1

  公开（公告）日：2011-06-09

  Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R 1 , R 4 , and R 5 are defined herein. Such compounds and compositions are useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine -2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.

  目前提供了按照公式(I)或(II)定义的化合物以及含有这些化合物的药物组合物，其中R1、R4和R5的定义在此处。这些化合物和组合物对于调节吲哚胺2,3-二氧化酶的活性；治疗吲哚胺2,3-二氧化酶(IDO)介导的免疫抑制；治疗从抑制吲哚胺-2,3-二氧化酶的酶活性中获益的医疗状况；增强包括给予抗癌剂的抗癌治疗的有效性；治疗与癌症相关的肿瘤特异性免疫抑制；以及治疗与传染性疾病相关的免疫抑制具有用处。
• US8748469B2
  申请人：——

  公开号：US8748469B2

  公开（公告）日：2014-06-10
• US9174942B2
  申请人：——

  公开号：US9174942B2

  公开（公告）日：2015-11-03
• [EN] IDO INHIBITORS<br/>[FR] INHIBITEURS DE L'IDO
  申请人：NEWLINK GENETICS

  公开号：WO2009132238A2

  公开（公告）日：2009-10-29

  Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R1, R4, and R5 are defined herein. Such compounds and compositions are useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine -2,3-dioxygenase; enhancing the effectiveness of an anti- cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosupression associated with an infectious disease.
• IDO inhibitors
  申请人：NewLink Genetics Corporation

  公开号：US09174942B2

  公开（公告）日：2015-11-03

  Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R1, R4, and R5 are defined herein. Such compounds and compositions are useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease.

  目前提供的是按照化学式(I)或(II)提供的化合物以及含有这些化合物的药物组合物，其中R1、R4和R5在此有定义。这些化合物和组合物可用于调节吲哌醇胺2,3-二氧化酶的活性；治疗吲哌醇胺2,3-二氧化酶（IDO）介导的免疫抑制；治疗受益于抑制吲哌醇胺-2,3-二氧化酶酶活性的医疗状况；增强包括给予抗癌剂的抗癌治疗的有效性；治疗与癌症相关的肿瘤特异性免疫抑制；以及治疗与传染性疾病相关的免疫抑制。