摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

5-(4-氟苯基)-2-氨基吡啶 | 503536-73-0

中文名称
5-(4-氟苯基)-2-氨基吡啶
中文别名
2-氨基-5-(4-氟苯基)吡啶
英文名称
5-(4-fluorophenyl)pyridin-2-amine
英文别名
5-(4-fluorophenyl)-2-pyridinamine
5-(4-氟苯基)-2-氨基吡啶化学式
CAS
503536-73-0
化学式
C11H9FN2
mdl
——
分子量
188.204
InChiKey
MQBSATGBKLUKNQ-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    320.6±27.0 °C(Predicted)
  • 密度:
    1.218

计算性质

  • 辛醇/水分配系数(LogP):
    2.2
  • 重原子数:
    14
  • 可旋转键数:
    1
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.0
  • 拓扑面积:
    38.9
  • 氢给体数:
    1
  • 氢受体数:
    3

安全信息

  • 海关编码:
    2933399090

SDS

SDS:ecd208b47a1e8928f41f93c5316ce292
查看
Material Safety Data Sheet

Section 1. Identification of the substance
Product Name: 5-(4-Fluorophenyl)pyridin-2-amine
Synonyms:

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section 3. Composition/information on ingredients.
Ingredient name: 5-(4-Fluorophenyl)pyridin-2-amine
CAS number: 503536-73-0

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C11H9FN2
Molecular weight: 188.2

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride.

Section 11. Toxicological information
No data.

Section 12. Ecological information
No data.

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
Non-harzardous for air and ground transportation.

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    5-(4-氟苯基)-2-氨基吡啶sodium acetate 作用下, 以 溶剂黄146 为溶剂, 反应 1.0h, 以60%的产率得到2-amino-3-bromo-5-(4-fluorophenyl)pyridine
    参考文献:
    名称:
    Aryl pyridines and methods of their use
    摘要:
    芳基吡啶,包括它们的组合物,以及它们用于治疗、预防和管理各种疾病和疾病的方法被披露。
    公开号:
    US20070032501A1
  • 作为产物:
    参考文献:
    名称:
    三氟吡啶并[1,2-a]嘧啶-2-酮衍生物的合成及其抗球虫活性的评价。
    摘要:
    筛选我们的化学文库以发现表现出抗艾美尔球虫侵袭宿主细胞的体外活性的新分子,发现了一种铅化合物,IC50为15μM。使用34种新合成的化合物进行了结构-活性关系研究,以鉴定更多活性分子并增强体外抗寄生虫活性。四种化合物在体外抑制MDBK细胞入侵方面比先导化合物更有效。
    DOI:
    10.1016/j.bmcl.2015.11.018
点击查看最新优质反应信息

文献信息

  • Compounds that modulate PPAR activity and methods of preparation
    申请人:——
    公开号:US20040209936A1
    公开(公告)日:2004-10-21
    This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing dyslipidemia, hypercholesterolemia, obesity, hyperglycemia, atherosclerosis, hypertriglyceridemia and hyperinsulinemia in a mammal. The present invention also relates to methods for making the disclosed compounds.
    这项发明涉及改变PPAR活性的化合物。该发明还涉及这些化合物的药用盐、包含这些化合物或其盐的药用组合物,以及将它们用作治疗或预防哺乳动物中的脂质代谢异常、高胆固醇血症、肥胖、高血糖、动脉粥样硬化、高甘油三酯血症和高胰岛素血症的治疗剂的方法。本发明还涉及制备所述化合物的方法。
  • 一种含氟苯酰胺类化合物及其制备方法和应用
    申请人:上海泰坦科技股份有限公司
    公开号:CN108329230A
    公开(公告)日:2018-07-27
    本发明提供一种含氟苯酰胺类化合物及其制备方法和应用,所述含氟苯酰胺类化合物具有式I所示结构,其结构简单,具有良好的抗凝血活性,可以延长凝血时间,所述化合物的制备方法简单高效,易于实现工业化生产。
  • Recyclable Pd/CuFe<sub>2</sub>O<sub>4</sub> nanowires: a highly active catalyst for C–C couplings and synthesis of benzofuran derivatives
    作者:Bhairi Lakshminarayana、Jhonti Chakraborty、G. Satyanarayana、Ch. Subrahmanyam
    DOI:10.1039/c8ra03697g
    日期:——

    Efficient heterogeneous Pd/CuFe2O4 nanowires which catalyze cross coupling transformations are described. The protocol is applied to a one-pot synthesis of benzofurans via Sonogashira coupling and an intramolecular etherification sequence.

    描述了高效的异质Pd/CuFe2O4纳米线,可催化交叉偶联反应。该方案应用于苯并呋喃的一锅合成,通过Sonogashira偶联和分子内醚化序列。
  • [EN] PHTHALIMIDE DERIVATIVES AS MODULATORS OF WNT PATHWAY<br/>[FR] DÉRIVÉS DE PHTALIMIDE À TITRE DE MODULATEURS DE LA VOIE WNT
    申请人:AGENCY SCIENCE TECH & RES
    公开号:WO2015187094A1
    公开(公告)日:2015-12-10
    The present invention relates to compounds of formula (I), [Formula should be inserted here] pharmaceutically acceptable salts, solvates and polymorphs thereof, including all tautomers and stereoisomers thereof, wherein R1 is alkyl; alkoxy-alkyl-; carbocyclyl; heterocyclyl; aryl; heteroaryl; aryl-alkyl-; heteroaryl- alkyl-; carbocyclyl-alkyl-; or heterocyclyl-alkyl-; R2 is H or alkyl; R3 is H or alkyl; Y is aryl; heteroaryl; carbocyclyl; or heterocyclyl; and Z is aryl; heteroaryl; carbocyclyl; or heterocyclyl.
    本发明涉及化合物的公式(I),其药学上可接受的盐、溶剂和多型体,包括其所有互变异构体和立体异构体,其中R1是烷基;烷氧基烷基;碳环烷基;杂环烷基;芳基;杂芳基;芳基烷基;杂芳基烷基;碳环烷基烷基;或杂环烷基烷基;R2是H或烷基;R3是H或烷基;Y是芳基;杂芳基;碳环烷基;或杂环烷基;Z是芳基;杂芳基;碳环烷基;或杂环烷基。
  • PEPTIDE DEFORMYLASE INHIBITORS
    申请人:Aubart Kelly M.
    公开号:US20130345120A1
    公开(公告)日:2013-12-26
    The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.
    本发明涉及一种化合物,其化学式为(I):或其药学上可接受的盐,相应的制药组合物,化合物制备和治疗方法,用于治疗细菌感染和抑制细菌肽变形酶(PDF)活性。
查看更多

同类化合物

(S)-氨氯地平-d4 (R,S)-可替宁N-氧化物-甲基-d3 (R)-N'-亚硝基尼古丁 (5E)-5-[(2,5-二甲基-1-吡啶-3-基-吡咯-3-基)亚甲基]-2-亚磺酰基-1,3-噻唑烷-4-酮 (5-溴-3-吡啶基)[4-(1-吡咯烷基)-1-哌啶基]甲酮 (5-氨基-6-氰基-7-甲基[1,2]噻唑并[4,5-b]吡啶-3-甲酰胺) (2S)-2-[[[9-丙-2-基-6-[(4-吡啶-2-基苯基)甲基氨基]嘌呤-2-基]氨基]丁-1-醇 (2R,2''R)-(+)-[N,N''-双(2-吡啶基甲基)]-2,2''-联吡咯烷四盐酸盐 黄色素-37 麦斯明-D4 麦司明 麝香吡啶 鲁非罗尼 鲁卡他胺 高氯酸N-甲基甲基吡啶正离子 高氯酸,吡啶 高奎宁酸 马来酸溴苯那敏 马来酸左氨氯地平 顺式-双(异硫氰基)(2,2'-联吡啶基-4,4'-二羧基)(4,4'-二-壬基-2'-联吡啶基)钌(II) 顺式-二氯二(4-氯吡啶)铂 顺式-二(2,2'-联吡啶)二氯铬氯化物 顺式-1-(4-甲氧基苄基)-3-羟基-5-(3-吡啶)-2-吡咯烷酮 顺-双(2,2-二吡啶)二氯化钌(II) 水合物 顺-双(2,2'-二吡啶基)二氯化钌(II)二水合物 顺-二氯二(吡啶)铂(II) 顺-二(2,2'-联吡啶)二氯化钌(II)二水合物 非那吡啶 非洛地平杂质C 非洛地平 非戈替尼 非尼拉朵 非尼拉敏 阿雷地平 阿瑞洛莫 阿培利司N-6 阿伐曲波帕杂质40 间硝苯地平 间-硝苯地平 锇二(2,2'-联吡啶)氯化物 链黑霉素 链黑菌素 银杏酮盐酸盐 铬二烟酸盐 铝三烟酸盐 铜-缩氨基硫脲络合物 铜(2+)乙酸酯吡啶(1:2:1) 铁5-甲氧基-6-甲基-1-氧代-2-吡啶酮 钾4-氨基-3,6-二氯-2-吡啶羧酸酯 钯,二氯双(3-氯吡啶-κN)-,(SP-4-1)-