6H-pyrrolo[2,3-g]quinoxaline-5,9-dione | 1236813-47-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6H-pyrrolo[2,3-g]quinoxaline-5,9-dione
• CAS: 1236813-47-0
• 化学式: C₁₀H₅N₃O₂
• 分子量: 199.169
• InChiKey: HJTRVENAXRIDOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  75.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6H-pyrrolo[2,3-g]quinoxaline-5,9-dione 、 N,N-二甲氨基氯丙烷盐酸盐 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以6%的产率得到6-[3-(Dimethylamino)propyl]pyrrolo[2,3-g]quinoxaline-5,9-dione
  参考文献：
  名称：

  Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives

  摘要：

  A series of azanaphthoquinone pyrrolo-annelated derivatives attached to basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines. The effects on cell cycle and intercalation were investigated. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.05.003
• 作为产物：
  描述：

  乙缩醛 、 6-Aminoquinoxaline-5,8-dione 在 manganese triacetate 作用下， 以 溶剂黄146 为溶剂， 反应 18.0h， 以19%的产率得到6H-pyrrolo[2,3-g]quinoxaline-5,9-dione
  参考文献：
  名称：

  Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives

  摘要：

  A series of azanaphthoquinone pyrrolo-annelated derivatives attached to basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines. The effects on cell cycle and intercalation were investigated. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.05.003

文献信息

• Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives
  作者：Karem Shanab、Eva Schirmer、Heike Knafl、Eva Wulz、Wolfgang Holzer、Helmut Spreitzer、Peter Schmidt、Babette Aicher、Gilbert Müller、Eckhard Günther

  DOI：10.1016/j.bmcl.2010.05.003

  日期：2010.7

  A series of azanaphthoquinone pyrrolo-annelated derivatives attached to basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines. The effects on cell cycle and intercalation were investigated. (c) 2010 Elsevier Ltd. All rights reserved.