4-[6-[2-(4-hydroxyphenyl)propan-2-yl]-2,2,4-trimethyl-3H-chromen-4-yl]phenol | 287110-79-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 4-[6-[2-(4-hydroxyphenyl)propan-2-yl]-2,2,4-trimethyl-3H-chromen-4-yl]phenol
• CAS: 287110-79-6
• 化学式: C₂₇H₃₀O₃
• 分子量: 402.533
• InChiKey: CTJRCTHSDUJGBK-UHFFFAOYSA-N

物化性质

• 沸点：
  536.5±50.0 °C(Predicted)
• 密度：
  1.122±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲硫醇 、 丙酮 、 苯酚 在 strongly acidic 2percent cross linked sulfonated styrene divinylbenzene cationic gel exchange resin CT₁₂₂ 作用下， 以 水 为溶剂， 反应 3.0h， 生成 双酚A 、 4-[6-[2-(4-hydroxyphenyl)propan-2-yl]-2,2,4-trimethyl-3H-chromen-4-yl]phenol 、 2,2-二(甲硫基)丙烷 、 2,2'-异亚丙基二苯酚 、 茚满双酚 、 2,4-二(1-(4-羟基苯基)异丙基)苯酚 、 4-甲硫基-4-甲基-2-戊酮 、 2,4’-异亚丙基二苯酚 、 5-hydroxy-1-(4'-hydroxyphenyl)-1,3,3-trimethylindan
  参考文献：
  名称：

  WO2007/130040

  摘要：

  公开号：

文献信息

• PROCESS FOR THE MANUFACTURE OF POLYPHENOLS
  申请人：Fetsko Stephen W.

  公开号：US20090137848A1

  公开（公告）日：2009-05-28

  An improved process for the manufacture of a polyphenol compound such as bisphenol-A by introducing into a reaction zone a phenolic compound reactant, a carbonyl compound reactant, and a catalyst promoter comprising bismethylthiopropane added to the reaction system in certain specific locations, and reacting the ingredients within the reaction zone in the presence of an acid catalyst.

  一种改进的制造多酚类化合物（如双酚-A）的工艺，通过将酚类反应物、羰基化合物反应物和催化剂促进剂（包括添加到反应系统中的双甲基硫代丙烷）引入反应区域的特定位置，并在酸性催化剂的存在下在反应区域内反应这些成分。
• TREATMENT OF BISPHENOL-A RESIDUE STREAMS
  申请人：PALMER David P.

  公开号：US20120310014A1

  公开（公告）日：2012-12-06

  In a method of treating a residue stream from the production of bisphenol-A, the residue stream is contacted with an aqueous solution of a base under conditions effective to hydrolyze at least part of said residue stream into acetone and phenol and produce an effluent stream. Acetone is recovered from the effluent stream to produce a phenol-containing mixed phase stream which is substantially free of acetone and which contains water and unhydrolyzed heavy organic compounds. The phenol-containing mixed phase stream is then treated with a water-immiscible organic solvent to extract phenol and unhydrolyzed heavy organic compounds into said solvent and produce an organic phase containing the solvent, phenol and unhydrolyzed heavy aromatic compounds and an aqueous phase with reduced concentrations of phenol and unhydrolyzed heavy organic compounds. At least part of the phenol and the organic solvent are subsequently recovered from the organic phase.

  一种处理双酚A生产废渣流的方法，包括将废渣流与碱性水溶液接触，在有效条件下使废渣流至少部分水解为丙酮和苯酚，并产生一种流出物。从流出物中回收丙酮，以产生含苯酚的混合相流，该流体基本上不含丙酮，含有水和未水解的重有机化合物。然后，将含苯酚的混合相流与不溶于水的有机溶剂处理，以提取苯酚和未水解的重有机化合物到所述溶剂中，并产生含有溶剂、苯酚和未水解的重芳香化合物的有机相和降低苯酚和未水解的重有机化合物浓度的水相。随后，从有机相中至少回收部分苯酚和有机溶剂。
• [EN] SYNTHESIS OF BISPHENOLS<br/>[FR] SYNTHÈSE DE BISPHÉNOLS
  申请人：SABIC GLOBAL TECHNOLOGIES BV

  公开号：WO2016009362A1

  公开（公告）日：2016-01-21

  Various embodiments disclosed relate to methods and apparatus for synthesizing various biphenols. In various embodiments, the present invention provides a method of making a bisphenol including feeding a phenol at or proximate to the first end of a reactor column including a first end and a second end and including a solid catalyst distributed in multiple locations between the first end and the second end of the reactor column. The method includes feeding an oxomethylene compound to the reactor column at a first location that is at or proximate the first end and at one or more additional locations between the first location and the second end of the reactor column, and removing at least some water from the reactor column. The method includes removing a product composition including a diphenolmethylene product at or proximate to the second end of the reactor column.

  本发明涉及用于合成各种双苯酚的方法和装置的各种实施方式。在各种实施方式中，本发明提供了一种制造双酚的方法，包括在反应器柱的第一端或靠近第一端处提供苯酚，并在反应器柱的第一端和第二端之间的多个位置分布有固体催化剂的反应器柱中，在第一位置处向反应器柱提供氧甲基化合物，在第一位置和第二端之间的一个或多个附加位置处向反应器柱提供氧甲基化合物，并从反应器柱中至少去除一些水。该方法包括在反应器柱的第二端或靠近第二端处去除包括双苯酚甲烷产物的产物组成。
• [EN] MANUFACTURE OF BISPHENOL A<br/>[FR] PRÉPARATION DE BISPHÉNOL A
  申请人：SABIC GLOBAL TECHNOLOGIES BV

  公开号：WO2018015923A1

  公开（公告）日：2018-01-25

  The invention is directed to a method for the manufacture of bisphenol A, and to bisphenol A/phenol adduct crystals. The method of the invention comprises: a) reacting phenol and acetone in the presence of an acidic catalyst to form a reaction product comprising an initial concentration of bisphenol A and an initial concentration of impurities; b) diluting the reaction product with phenol, water and/or acetone, so as to decrease the impurity concentration to 50 % by weight or less of the initial concentration of impurities, and adding bisphenol A to increase the concentration thereof in the reaction product; and thereafter c) crystallising a bisphenol A/phenol adduct from the reaction product to produce a crystallised bisphenol A product.

  本发明涉及一种制备双酚A的方法，以及双酚A/苯酚加合物晶体。该发明的方法包括：a) 在酸性催化剂存在下，将苯酚和丙酮反应，形成反应产物，其中包括双酚A的初始浓度和杂质的初始浓度；b) 用苯酚、水和/或丙酮稀释反应产物，使杂质浓度降至初始杂质浓度的50%或更低，并添加双酚A以增加反应产物中的浓度；然后c) 从反应产物中结晶出双酚A/苯酚加合物，以生产结晶双酚A产品。
• Methods for purifying p,p-bisphenol-A
  申请人：Kumar Ramachandran

  公开号：US20060069292A1

  公开（公告）日：2006-03-30

  Methods for purifying a p,p-bisphenol A generally include distilling a feed stream comprising p,p-BPA in a distillation column at a pressure less than or equal to 20 millibars. The distillation column separates the bisphenol feed stream to produce a light fraction, an intermediate fraction and a heavy fraction. The intermediate fraction comprising the purified bisphenol contains lesser impurities that the p,p-BPA in the feed stream. In one embodiment, the intermediate stream is recovered using a side-draw. The side-draw is located between a first zone and a third zone in the distillation column.

  p,p-双酚A的纯化方法通常包括在低于或等于20毫巴的压力下，在蒸馏塔中蒸馏含有p,p-BPA的进料流。蒸馏塔将双酚进料流分离成轻质组分、中间组分和重质组分。包含纯化双酚的中间组分含有比进料流中的p,p-BPA更少的杂质。在一种实施例中，通过侧流回收中间流。侧流位于蒸馏塔中第一区和第三区之间。