N-(5-methylisoxazol-3-yl)-4-(5-methyl-2-oxindolin-3-ylideneamino)benzenesulphonamide | 1393098-76-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(5-methylisoxazol-3-yl)-4-(5-methyl-2-oxindolin-3-ylideneamino)benzenesulphonamide
• 英文别名: N-(5-methyl-1,2-oxazol-3-yl)-4-[(5-methyl-2-oxo-1H-indol-3-ylidene)amino]benzenesulfonamide
• CAS: 1393098-76-4
• 化学式: C₁₉H₁₆N₄O₄S
• 分子量: 396.426
• InChiKey: YBACAIMIFDNXKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  122
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-甲基靛红 、 磺胺甲恶唑 以 乙醇 为溶剂， 反应 8.0h， 以78%的产率得到N-(5-methylisoxazol-3-yl)-4-(5-methyl-2-oxindolin-3-ylideneamino)benzenesulphonamide
  参考文献：
  名称：

  Synthesis, characterization andin vitroantimicrobial evaluation of new compounds incorporating oxindole nucleus

  摘要：

  New compounds incorporating with the oxindole nucleus were synthesized via the reaction of substituted isatins [5-methyl-, 5-chloro-and 1-hydroxymethyl isatins] with different nucleophiles. The structures of the newly compounds were elucidated on the basis of FTIR, H-1 NMR, (CMR)-C-13 spectral data, GC/MS and chemical analysis. Investigation of antimicrobial activity of the new compounds was evaluated using broth dilution technique in terms of minimal inhibitory concentration (MIC) count against four pathogenic bacteria and two pathogenic fungi. Most of the new compounds are significantly active against bacteria and fungi. MIC showed that compound (4a) possesses higher effect on Gram-positive bacteria Bacillus cereus than the selected antibacterial agent sulphamethoxazole, whereas compound (11c) possesses more activity against Gram-negative bacteria Shigella dysenterie.

  DOI：

  10.3109/14756366.2011.576251

文献信息

• Synthesis, characterization and<i>in vitro</i>antimicrobial evaluation of new compounds incorporating oxindole nucleus
  作者：Nadia G. Kandile、Howida T. Zaky、Mansoura I. Mohamed、Hind M. Ismaeel、Nashwa A. Ahmed

  DOI：10.3109/14756366.2011.576251

  日期：2012.8.1

  New compounds incorporating with the oxindole nucleus were synthesized via the reaction of substituted isatins [5-methyl-, 5-chloro-and 1-hydroxymethyl isatins] with different nucleophiles. The structures of the newly compounds were elucidated on the basis of FTIR, H-1 NMR, (CMR)-C-13 spectral data, GC/MS and chemical analysis. Investigation of antimicrobial activity of the new compounds was evaluated using broth dilution technique in terms of minimal inhibitory concentration (MIC) count against four pathogenic bacteria and two pathogenic fungi. Most of the new compounds are significantly active against bacteria and fungi. MIC showed that compound (4a) possesses higher effect on Gram-positive bacteria Bacillus cereus than the selected antibacterial agent sulphamethoxazole, whereas compound (11c) possesses more activity against Gram-negative bacteria Shigella dysenterie.