5-methyl-6-phenyl-imidazo[2,1-b][1,3,4]thiadiazole | 57772-02-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-methyl-6-phenyl-imidazo[2,1-b][1,3,4]thiadiazole
• 英文别名: 5-Methyl-6-phenyl-imidazo<2,1-b>-1,3,4-thiadiazol；5-Methyl-6-phenylimidazo[2,1-b][1,3,4]thiadiazole
• CAS: 57772-02-8
• 化学式: C₁₁H₉N₃S
• 分子量: 215.279
• InChiKey: VLIXFLTVXROETJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  58.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基-1,3,4-噻二唑 、 2-溴苯丙酮 以 乙醇 为溶剂， 生成 5-methyl-6-phenyl-imidazo[2,1-b][1,3,4]thiadiazole
  参考文献：
  名称：

  Pentimalli,L. et al., Gazzetta Chimica Italiana, 1975, vol. 105, p. 777 - 787

  摘要：

  DOI：

文献信息

• PENTIMALLI L.; MILANI G.; BIAVATI F., GAZZ. CHIM. ITAL. <GCIT-A9>, 1975, 105, NO 7-8, 777-787
  作者：PENTIMALLI L.、 MILANI G.、 BIAVATI F.

  DOI：——

  日期：——
• PYRROLIDINYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
  申请人：ARRAY BIOPHARMA INC.

  公开号：US20160297758A1

  公开（公告）日：2016-10-13

  Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R 1 , R 2 , R a , R b , R c , R d , X, Ring B, and Ring C are as defined herein, and wherein Ring B moiety and the NH—C(═X)—NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
• US9790178B2
  申请人：——

  公开号：US9790178B2

  公开（公告）日：2017-10-17