S-(3-hydroxy-propionyl)-coenzyme-A | 157786-88-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: S-(3-hydroxy-propionyl)-coenzyme-A
• 英文别名: S-(3-Hydroxy-propionyl)-coenzym-A；3-Hydroxypropanoyl-CoA；S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-hydroxypropanethioate
• CAS: 157786-88-4
• 化学式: C₂₄H₄₀N₇O₁₈P₃S
• 分子量: 839.605
• InChiKey: BERBFZCUSMQABM-IEXPHMLFSA-N

物化性质

• 密度：
  1.91±0.1 g/cm3(Predicted)
• 物理描述：
  Solid
• 熔点：
  121.5°C

计算性质

• 辛醇/水分配系数(LogP)：
  -6.4
• 重原子数：
  53
• 可旋转键数：
  22
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  409
• 氢给体数：
  10
• 氢受体数：
  23

反应信息

• 作为反应物：
  描述：

  S-(3-hydroxy-propionyl)-coenzyme-A 生成 丙二酰-辅酶A半醛
  参考文献：
  名称：

  Vagelos; Earl, Journal of Biological Chemistry, 1959, vol. 234, p. 2272,2273

  摘要：

  DOI：
• 作为产物：
  描述：

  S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-氨基嘌呤-9-基)-4-羟基-3-膦酰氧基四氢呋喃-2-基]甲氧基-羟基磷酰]氧基-羟基磷酰]氧基-2-羟基-3,3-二甲基丁酰基]氨基]丙酰氨基]乙基]硫代丙-2-烯酸 生成 S-(3-hydroxy-propionyl)-coenzyme-A
  参考文献：
  名称：

  Rendina; Coon, Journal of Biological Chemistry, 1957, vol. 225, p. 523,531

  摘要：

  DOI：

文献信息

• [EN] METHODS FOR PRODUCING 3-HYDROXY-3-METHYLBUTYRIC ACID<br/>[FR] PROCÉDÉS POUR PRODUIRE DE L'ACIDE 3-HYDROXY-3-MÉTHYLBUTYRIQUE
  申请人：GLOBAL BIOENERGIES

  公开号：WO2016042012A1

  公开（公告）日：2016-03-24

  Described is a method for the conversion of 3-methylcrotonyl-CoA into 3-hydroxy-3- methylbutyric acid comprising the steps of: (a) enzymatically converting 3-methylcrotonyl-CoA into 3-hydroxy-3-methylbutyryl-CoA; and (b) further enzymatically converting the thus produced 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyric acid wherein the enzymatic conversion of 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyric acid according to step (b) is achieved by first converting 3-hydroxy-3-methylbutyryl-CoA into 3-hydroxy-3-methylbutyryl phosphate and then subsequently converting the thus produced 3-hydroxy-3-methylbutyryl phosphate into 3-hydroxy-3-methylbutyric acid.

  描述了一种将3-甲基丙酰辅酶A转化为3-羟基-3-甲基丁酸的方法，包括以下步骤：(a)将3-甲基丙酰辅酶A酶促转化为3-羟基-3-甲基丁酰辅酶A；(b)进一步将所产生的3-羟基-3-甲基丁酰辅酶A酶促转化为3-羟基-3-甲基丁酸，其中根据步骤(b)将3-羟基-3-甲基丁酰辅酶A酶促转化为3-羟基-3-甲基丁酸的方法是首先将3-羟基-3-甲基丁酰辅酶A转化为3-羟基-3-甲基丁酰磷酸，然后随后将所产生的3-羟基-3-甲基丁酰磷酸转化为3-羟基-3-甲基丁酸。
• [EN] RENEWABLE ACRYLIC ACID PRODUCTION AND PRODUCTS MADE THEREFROM<br/>[FR] PRODUCTION D'ACIDE ACRYLIQUE RENOUVELABLE ET PRODUITS FABRIQUÉS À PARTIR DE CELUI-CI
  申请人：METABOLIX INC

  公开号：WO2013185009A1

  公开（公告）日：2013-12-12

  Processes and methods for making biobased acrylic acid products including acrylic acid, acrylic acid oligomers, acrylic acid esters, acrylic acid polymers and articles from renewable carbon resources are described herein.

  本文描述了制造基于生物的丙烯酸产品的过程和方法，包括丙烯酸、丙烯酸寡聚体、丙烯酸酯、丙烯酸聚合物以及利用可再生碳资源制成的物品。
• [EN] ENZYMATIC PRODUCTION OF ACRYLYL-COA OR ETHYLENE FROM GLYCEROL<br/>[FR] PRODUCTION ENZYMATIQUE D'ACRYLYL-COA OU D'ÉTHYLÈNE À PARTIR DE GLYCÉROL
  申请人：GLOBAL BIOENERGIES

  公开号：WO2016097289A1

  公开（公告）日：2016-06-23

  Described is a method for the production of acrylyl-CoA from glycerol comprising the following steps: (a) the enzymatic conversion of glycerol into 3-hydroxypropionaldehyde; (b) the enzymatic conversion of said 3-hydroxypropionaldehyde into 3-hydroxypropionyl-CoA; and (c) the enzymatic conversion of said 3-hydroxypropionyl-CoA into acrylyl-CoA. Further enzymatic conversion of acrylyl-CoA into other products are disclosed. Further described is a method for the production of ethylene comprising the enzymatic conversion of propionic acid into ethylene. It is described that the enzymatic conversion of propionic acid into ethylene can be achieved by making use of a cytochrome P450 fatty acid decarboxylase or a non-heme iron oxygenase. Further, it is described that said propionic acid can be obtained by the enzymatic conversion of acrylyl-CoA into said propionic acid.

  描述了一种从甘油生产丙烯酰辅酶A的方法，包括以下步骤：(a) 将甘油酶转化为3-羟基丙醛；(b) 将所述3-羟基丙醛酶转化为3-羟基丙酰辅酶A；以及(c) 将所述3-羟基丙酰辅酶A酶转化为丙烯酰辅酶A。进一步披露了丙烯酰辅酶A的进一步酶转化为其他产品的方法。进一步描述了一种生产乙烯的方法，包括将丙酸酶转化为乙烯。描述了通过利用细胞色素P450脂肪酸脱羧酶或非血红素铁氧酶将丙酸酶转化为乙烯的方法。此外，还描述了通过将丙烯酰辅酶A酶转化为所述丙酸来获得所述丙酸的方法。
• [EN] METHYLENEMALONIC ACID AND INTERMEDIATES, PROCESSES FOR THEIR PREPARATION AND ENGINEERED MICROORGANISMS<br/>[FR] ACIDE MÉTHYLÈNEMALONIQUE ET INTERMÉDIAIRES, PROCÉDÉS POUR LEUR PRÉPARATION ET MICRO-ORGANISMES MODIFIÉS
  申请人：BIOAMBER INC

  公开号：WO2018018151A1

  公开（公告）日：2018-02-01

  The description relates to, inter alia, recombinant microorganisms, engineered metabolic pathways, chemical catalysts, and products produced through the use of the described methods and materials. The products produced include methylenemalonic acid and intermediates, as well as their salts and esters.

  该描述涉及重组微生物、工程代谢途径、化学催化剂以及通过所述方法和材料生产的产品。所生产的产品包括亚甲基丙二酸和中间体，以及它们的盐和酯。
• GREEN PROCESS AND COMPOSITIONS FOR PRODUCING POLY(5HV) AND 5 CARBON CHEMICALS
  申请人：Farmer William R.

  公开号：US20100168481A1

  公开（公告）日：2010-07-01

  Recombinant hosts for producing polyhydroxyalkanoates and methods of producing polyhydroxyalkanoates from renewable carbon substrates are provided. Certain recombinant hosts that produce 5 carbon chemicals such as 5-aminopentanoate (5AP), 5-hydroxyvalerate (5HV), glutarate, and 1,5 pentanediol (PDO) are also provided. One embodiment provides a recombinant host expressing a gene encoding a heterologous enzyme selected from the group consisting of a polyhydroxyalkanoate synthase and a 5-hydroxyvalerate-CoA (5HV-CoA) transferase, wherein the host produces a polymer containing 5-hydroxyvalerate. Preferably, the host expresses both a polyhydroxyalkanoate synthase and a 5HV-CoA transferase. The host can be prokaryotic or eukaryotic. A preferred prokaryotic host is E. coli . The polymers produced by the recombinant hosts can be homopolymers or copolymers of 5-hydroxyvalerate. A preferred copolymer is poly(3-hydroxybutyrate-co-5-hydroxyvalerate).

  本发明提供了用于生产聚羟基脂肪酸酯的重组宿主以及从可再生碳底物生产聚羟基脂肪酸酯的方法。本发明还提供了某些重组宿主，它们可以产生5碳化学品，例如5-氨基戊酸（5AP）、5-羟基戊酸（5HV）、戊二酸和1,5-戊二醇（PDO）。其中一种实施例提供了一种表达编码异源酶的基因的重组宿主，所述异源酶选自聚羟基脂肪酸酯合成酶和5-羟基戊酸-CoA（5HV-CoA）转移酶的群组，其中所述宿主产生含有5-羟基戊酸的聚合物。最好，宿主同时表达聚羟基脂肪酸酯合成酶和5HV-CoA转移酶。宿主可以是原核生物或真核生物。优选的原核生物宿主是大肠杆菌（E. coli）。重组宿主产生的聚合物可以是5-羟基戊酸的同源聚合物或共聚物。优选的共聚物是聚（3-羟基丁酸-5-羟基戊酸）。