2-(p-methylphenyl)-6-methylimidazo<2,1-b>benzothiazole | 38956-31-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(p-methylphenyl)-6-methylimidazo<2,1-b>benzothiazole
• 英文别名: 7-methyl-2-p-tolyl-benzo[d]imidazo[2,1-b]thiazole；7-methyl-2-p-tolyl-benzo[d]imidazo[2,1-b]thiazole；7-Methyl-2-(4-methylphenyl)imidazo[2,1-b][1,3]benzothiazole；6-methyl-2-(4-methylphenyl)imidazo[2,1-b][1,3]benzothiazole
• CAS: 38956-31-9
• 化学式: C₁₇H₁₄N₂S
• mdl: MFCD01531384
• 分子量: 278.378
• InChiKey: IJKSUSSSTHTRIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  45.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(p-methylphenyl)-6-methylimidazo<2,1-b>benzothiazole 、 正丁基锂 、 四氢呋喃 以50%的产率得到
  参考文献：
  名称：

  MASE, TOSHIYASU;MURASE, KIYOSHI, HETEROCYCLES, 26,(1987) N 12, 3159-3164

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基-6-甲基苯并噻唑 、 对甲基苯乙酮 在 iron(III) chloride 、 zinc(II) iodide 作用下， 以 邻二氯苯 为溶剂， 反应 15.0h， 以85%的产率得到2-(p-methylphenyl)-6-methylimidazo<2,1-b>benzothiazole
  参考文献：
  名称：

  FeCl₃/ZnI₂-Catalyzed Synthesis of Benzo[d]imidazo[2,1-b]thiazole through Aerobic Oxidative Cyclization between 2-Aminobenzothiazole and Ketone

  摘要：

  The FeCl3/ZnI2-catalyzed aerobic oxidative cyclization between 2-aminobenzothiazole and ketone/chalcone for the synthesis of benzo[d]imidazo[2,1-b]thiazole is described. A variety of fused benzoimidazothiazole derivatives are obtained by this protocol.

  DOI：

  10.1021/ol5028893

文献信息

• Iron-catalyzed unprecedented formation of benzo[d]imidazo[2,1-b]thiazoles under solvent-free conditions
  作者：Sandip Gangadhar Balwe、Yeon Tae Jeong

  DOI：10.1039/c6ra24183b

  日期：——

  unprecedented formation of benzo[d]imidazo[2,1-b]thiazole during iron-catalyzed coupling of 2-aminobenzothiazole, aldehydes with nitroalkane in air has been observed. This unique transformation possibly occurs through a sequential aza-Henry reaction and subsequent intramolecular cyclization, followed by denitration. A variety of substituted benzo[d]imidazo[2,1-b]thiazole are obtained using this protocol

  观察到在空气中2-氨基苯并噻唑，醛与硝基烷的铁催化偶联过程中，苯并[ d ]咪唑并[ 2,1- b ]噻唑的空前形成。这种独特的转化可能是通过顺序的aza-Henry反应和随后的分子内环化，然后进行脱硝而发生的。使用该方案可获得各种取代的苯并[ d ]咪唑并[2,1- b ]噻唑。
• Investigations in the imidazole series
  作者：N. P. Grin'、A. N. Krasovskii、P. M. Kochergin

  DOI：10.1007/bf00944233

  日期：1972.9
• Nucleophilic Substitution Reactions on Sulfur by n-Butyllithium 2
  作者：Toshiyasu Mase、Kiyoshi Murase

  DOI：10.3987/r-1987-12-3159

  日期：——
• FeCl₃/ZnI₂-Catalyzed Synthesis of Benzo[<i>d</i>]imidazo[2,1-<i>b</i>]thiazole through Aerobic Oxidative Cyclization between 2-Aminobenzothiazole and Ketone
  作者：Subhajit Mishra、Kamarul Monir、Shubhanjan Mitra、Alakananda Hajra

  DOI：10.1021/ol5028893

  日期：2014.12.5

  The FeCl3/ZnI2-catalyzed aerobic oxidative cyclization between 2-aminobenzothiazole and ketone/chalcone for the synthesis of benzo[d]imidazo[2,1-b]thiazole is described. A variety of fused benzoimidazothiazole derivatives are obtained by this protocol.
• MASE, TOSHIYASU;MURASE, KIYOSHI, HETEROCYCLES, 26,(1987) N 12, 3159-3164
  作者：MASE, TOSHIYASU、MURASE, KIYOSHI

  DOI：——

  日期：——