1-(4-Trimethylsilanyl-thiazol-2-yl)-ethanone | 112970-10-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-Trimethylsilanyl-thiazol-2-yl)-ethanone
• 英文别名: 1-(4-trimethylsilyl-1,3-thiazol-2-yl)ethanone
• CAS: 112970-10-2
• 化学式: C₈H₁₃NOSSi
• 分子量: 199.349
• InChiKey: YIBQUTYVFYENPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.89
• 重原子数：
  12.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.96
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  3-methylthiazolo[3,2-c][1,2,3]triazole 在 正丁基锂 、 selenium(IV) oxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.17h， 生成 1-(4-Trimethylsilanyl-thiazol-2-yl)-ethanone
  参考文献：
  名称：

  1,2,3-Triazolo[5,1-b]thiazoles. Part 2 Lithiation experiments leading to 2,4-disubstituted thiazoles

  摘要：

  3-Methyltriazolothiazole (2) and 3-phenyltriazolothiazole (3) were regiospecifically lithiated at position 6, triazolothiazole (1) at position 6 and 3 with the former predominating. The lithiated triazolothiazoles (4), (10) and (11) reacted with a number of electrophiles to give x:6-disubstituted triazolothiazoles, which could be converted into 2,4-disubstituted thiazoles.

  DOI：

  10.1016/s0040-4020(01)87091-5

文献信息

• Synthesis of (trimethylsilyl)thiazoles and reactions with carbonyl compounds. Selectivity aspects and synthetic utility
  作者：Alessandro Dondoni、Giancarlo Fantin、Marco Fogagnolo、Alessandro Medici、Paola Pedrini

  DOI：10.1021/jo00243a029

  日期：1988.4
• DONDONI, ALESSANDRO;FANTIN, GIANCARLO;FOGAGNOLO, MARCO;MEDICI, ALESSANDRO+, J. ORG. CHEM., 53,(1988) N 8, 1748-1761
  作者：DONDONI, ALESSANDRO、FANTIN, GIANCARLO、FOGAGNOLO, MARCO、MEDICI, ALESSANDRO+

  DOI：——

  日期：——
• 1,2,3-Triazolo[5,1-b]thiazoles. Part 2 Lithiation experiments leading to 2,4-disubstituted thiazoles
  作者：Gurnos Jones、Hermione Ollivierre、L.S. Fuller、J.H. Young

  DOI：10.1016/s0040-4020(01)87091-5

  日期：1991.1

  3-Methyltriazolothiazole (2) and 3-phenyltriazolothiazole (3) were regiospecifically lithiated at position 6, triazolothiazole (1) at position 6 and 3 with the former predominating. The lithiated triazolothiazoles (4), (10) and (11) reacted with a number of electrophiles to give x:6-disubstituted triazolothiazoles, which could be converted into 2,4-disubstituted thiazoles.