2-formyl-1,1'-biphenyl-4,4'-dicarboxylic acid | 1095432-76-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-formyl-1,1'-biphenyl-4,4'-dicarboxylic acid
• 英文别名: 2-Formyl-[1,1'-biphenyl]-4,4'-dicarboxylic acid；4-(4-carboxyphenyl)-3-formylbenzoic acid
• CAS: 1095432-76-0
• 化学式: C₁₅H₁₀O₅
• 分子量: 270.241
• InChiKey: XMGKDEXRUPGLHM-UHFFFAOYSA-N

物化性质

• 沸点：
  546.1±50.0 °C(Predicted)
• 密度：
  1.411±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-formyl-1,1'-biphenyl-4,4'-dicarboxylic acid 、 2,4-二硝基苯肼 以 1,4-二氧六环 为溶剂， 以100%的产率得到2-((2-(2,4-dinitrophenyl)hydrazineylidene)methyl)-[1,1'-biphenyl]-4,4'-dicarboxylic acid
  参考文献：
  名称：

  标记金属有机骨架的合成后修饰。

  摘要：

  DOI：

  10.1002/anie.200802908
• 作为产物：
  描述：

  4-溴-3-甲基苯甲酸甲酯 在 chromium(VI) oxide 、 盐酸 、 硫酸 、 palladium diacetate 、 sodium carbonate 、 溶剂黄146 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-formyl-1,1'-biphenyl-4,4'-dicarboxylic acid
  参考文献：
  名称：

  醛标记的锆金属有机框架：合成后修饰的多功能平台

  摘要：

  醛标记的UiO-67型金属有机骨架（MOF）是通过直接溶剂热法或合成后的配体交换合成的。利用醛标记的C–N和C–C偶联反应，通过后合成修饰（PSM）将各种功能引入MOF。串联PSM也已被证明。通过PSM获得的氨基官能化MOF被证明是用于Knoevenagel缩合反应的高效，多相且可回收的催化剂。

  DOI：

  10.1021/acs.inorgchem.6b00598

文献信息

• An <i>in situ</i> approach to functionalize metal–organic frameworks with tertiary aliphatic amino groups
  作者：Fu-Gui Xi、Wei Sun、Zhi-yun Dong、Ning-Ning Yang、Teng Gong、En-Qing Gao

  DOI：10.1039/d0cc05568a

  日期：——

  N-dialkylformamide solvents is concomitant with the solvothermal coordination assembly, leading to novel MOFs functionalized with tertiary aliphatic amino groups. This illustrates a novel one-pot strategy to functionalize MOFs through in situ organic transformation. The UiO-66 MOFs partially functionalized with the amino groups are highly active heterogeneous catalysts for Knoevenagel condensation.

  用N，N-二烷基甲酰胺溶剂对含甲酰基的连接基进行金属催化的还原胺化反应与溶剂热配位组合同时发生，从而导致新型MOF被脂族叔氨基官能化。这说明了通过原位有机转化功能化MOF的新型一锅法。用氨基部分官能化的UiO-66 MOF是Knoevenagel缩合反应的高活性多相催化剂。
• Stepwise Assembly of Turn‐on Fluorescence Sensors in Multicomponent Metal–Organic Frameworks for in Vitro Cyanide Detection
  作者：Jialuo Li、Shuai Yuan、Jun‐Sheng Qin、Jiandong Pang、Peng Zhang、Yingmu Zhang、Yanyan Huang、Hannah F. Drake、Wenshe R. Liu、Hong‐Cai Zhou

  DOI：10.1002/anie.202000702

  日期：2020.6.8

  controlled synthesis of multicomponent metal–organic frameworks (MOFs) allows for the precise placement of multiple cooperative functional groups within a framework, leading to emergent synergistic effects. Herein, we demonstrate that turn‐on fluorescence sensors can be assembled by combining a fluorophore and a recognition moiety within a complex cavity of a multicomponent MOF. An anthracene‐based

  多组分金属-有机框架（MOF）的受控合成可以在框架内精确定位多个协作官能团，从而产生新的协同效应。在本文中，我们证明可以通过在多组分MOF的复杂腔体内组合荧光团和识别部分来组装开启型荧光传感器。基于蒽的荧光接头和一个含CN半花青- -响应性接头依次安装到PCN-700的晶格。选择性CN结合-半胱氨酸的抑制作用抑制了两个部分之间的能量转移，从而产生了荧光开启效应。利用MOF平台的高可调性，可以微调蒽和半菁部分之间的比例，以最大程度地提高整个框架的敏感性。优化的MOF-传感器有一个CN - 0.05μ -检测极限米，这比传统的CN非常低-荧光传感器（大约0.2μ米）。
• Mimic of the Green Fluorescent Protein β-Barrel: Photophysics and Dynamics of Confined Chromophores Defined by a Rigid Porous Scaffold
  作者：Derek E. Williams、Ekaterina A. Dolgopolova、Perry J. Pellechia、Andrei Palukoshka、Thomas J. Wilson、Rui Tan、Josef M. Maier、Andrew B. Greytak、Mark D. Smith、Jeanette A. Krause、Natalia B. Shustova

  DOI：10.1021/ja5131269

  日期：2015.2.18

  Chromophores with a benzylidene imidazolidinone core define the emission profile of commonly used biomarkers such as the green fluorescent protein (GFP) and its analogues. In this communication, artificially engineered porous scaffolds have been shown to mimic the protein beta-barrel structure, maintaining green fluorescence response and conformational rigidity of GFP-like chromophores. In particular, we demonstrated that the emission maximum in our artificial scaffolds is similar to those observed in the spectra of the natural GFP-based systems. To correlate the fluorescence response with a structure and perform a comprehensive analysis of the prepared photoluminescent scaffolds, C-13 cross-polarization magic angle spinning solid-state (CP-MAS) NMR spectroscopy, powder and single-crystal X-ray diffraction, and time-resolved fluorescence spectroscopy were employed. Quadrupolar spinecho solid-state H-2 NMR spectroscopy, in combination with theoretical calculations, was implemented to probe low-frequency vibrational dynamics of the confined chromophores, demonstrating conformational restrictions imposed on the coordinatively trapped chromophores. Because of possible tunability of the introduced scaffolds, these studies could foreshadow utilization of the presented approach toward directing a fluorescence response in artificial GFP mimics, modulating a protein microenvironment, and controlling nonradiative pathways through chromophore dynamics.
• Orthogonal Ternary Functionalization of a Mesoporous Metal–Organic Framework via Sequential Postsynthetic Ligand Exchange
  作者：Chong Liu、Tian-Yi Luo、Evan S. Feura、Chen Zhang、Nathaniel L. Rosi

  DOI：10.1021/jacs.5b06780

  日期：2015.8.26

  A sequential postsynthetic ligand exchange process was used to prepare a series of mono-, di-, and trifunctionalized mesoporous metal-organic frameworks (MOFs). Using this process, orthogonal functional groups were installed and thereafter postsynthetically modified with dye and quencher molecules. Microspectrophotometry studies were used to determine the distribution of the two orthogonal functional groups within the MOF crystals.