2-phenoxy-3-pyridinol | 263390-56-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-phenoxy-3-pyridinol
• 英文别名: 2-Phenoxypyridin-3-ol
• CAS: 263390-56-3
• 化学式: C₁₁H₉NO₂
• 分子量: 187.198
• InChiKey: JOEQIEKMEQPYQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-phenoxy-3-pyridinol 生成 2-phenoxy-3-[3-(3-hydroxypyridin-4-yl)propoxy]pyridine
  参考文献：
  名称：

  2,3-disubstituted pyridine derivatives, process for the preparation thereof, drug compositions containing the same and intermediates for the preparation

  摘要：

  一种具有式（I）的化合物，其中A为O、S、CHR1或NR2，R1和R2为H、较低的烷基，X1和X2为H、卤素、硝基、氰基等，Y1为H、较低的烷基，Z1和Z2为H、卤素、氰基、羟基、较低的烷基等，n为2至4的整数，其药学上可接受的盐，制备该化合物的方法，含有该化合物作为活性成分的药物组合物，以及其中间体。本发明的化合物（I）显示出强大的PDE IV抑制活性以及出色的支气管扩张活性，因此，在过敏性炎症性疾病或器官炎症性疾病的治疗或预防中，特别是在伴有气道阻塞的肺部疾病（如哮喘）的治疗或预防中，它们被广泛用作PDE IV抑制剂。

  公开号：

  US06555557B1

文献信息

• Diphenyl ether antimicrobial compounds
  申请人：Tonge J. Peter

  公开号：US20060041025A1

  公开（公告）日：2006-02-23

  The present invention is directed to compounds having the formula: wherein A 1 , A 3 , A 6 , and A 8 independently represent CH or N; A 2 represents N or C—X 1 a —R 1 ; A 4 represents N or C—X 2 b —R 2 ; R 1 and R 2 independently represent H, or a hydrocarbon containing a minimum of one carbon atom and a maximum of twenty six carbon atoms, wherein the hydrocarbon is unsubstituted, or is substituted with one or more of —OH, —NH 2 , —SH, halo, or —COOH; X 1 and X 2 independently represent —O—, —S—, —NH—, —C(O)O—, —C(O)—, —C(O)NH—, or —SO 2 NH—; a and b independently represent 0 or 1, provided that when a and b are both 0, then R 1 and R 2 are not both H; when a is 1, then R 1 is not H; and when b is 1, then R 2 is not H; A 5 and A 9 independently represent CR 3 or N; R 3 represents H, methyl, ethyl, or halo; A 7 represents CR 4 or N; R 4 represents H, methyl, ethyl, halo, nitro, hydroxy, amino, amido, or a methyl or ethyl group substituted with halo, nitro, hydroxy, amino, or amido; provided that A 2 and A 4 are not both N; and not more than three of A 5 , A 6 , A 7 , A 8 , and A 9 are N. The invention is also directed to pharmaceutical compositions comprising a compound according to (1) and a pharmaceutically acceptable carrier. The invention is also directed to methods of inhibiting the growth of a bacterium containing an enoyl reductase enzyme encoded by a fabI gene, a fabK gene, a fabL gene, or a combination thereof, in a mammal in need thereof, the method comprising administering to the mammal an effective amount of a compound according to formula (1).

  本发明涉及具有以下式的化合物：其中A1、A3、A6和A8独立地表示CH或N；A2表示N或C-X1a-R1；A4表示N或C-X2b-R2；R1和R2独立地表示H，或含有至少一个碳原子和最多二十六个碳原子的碳氢化合物，其中该碳氢化合物未经取代或用一种或多种-OH、NH2、SH、卤素或-COOH取代；X1和X2独立地表示-O-、-S-、-NH-、-C（O）O-、-C（O）-、-C（O）NH-或-SO2NH-；a和b独立地表示0或1，但当a和b都为0时，R1和R2不同时为H；当a为1时，R1不为H；当b为1时，R2不为H；A5和A9独立地表示CR3或N；R3表示H、甲基、乙基或卤素；A7表示CR4或N；R4表示H、甲基、乙基、卤素、硝基、羟基、氨基、酰胺基或用卤素、硝基、羟基、氨基或酰胺基取代的甲基或乙基基团；其中A2和A4不同时为N；且A5、A6、A7、A8和A9中不超过三个为N。本发明还涉及包含式（1）的化合物和药学上可接受的载体的制药组合物。本发明还涉及一种抑制哺乳动物中编码fabI基因、fabK基因、fabL基因或其组合的烯醇还原酶酶的细菌的生长的方法，该方法包括向哺乳动物中施加有效量的符合式（1）的化合物。
• 2,3-Disubstituted pyridine derivative, process for the preparation thereof, pharmaceutical composition containing the same, and intermediate therefor
  申请人：——

  公开号：US20030195232A1

  公开（公告）日：2003-10-16

  A compound of the formula (I) 1 wherein A is O, S, CHR 1 or NR 2 , R 1 and R 2 are H, lower alkyl, X 1 and X 2 are H, halogen, nitro, cyano, etc., Y 1 is H, lower alkyl, Z 1 and Z 2 are H, halogen, cyano, hydroxy, lower alkyl, etc., and n is an integer of 2 to 4, a pharmaceutically acceptable salt thereof, a process for preparing the same, a pharmaceutical composition containing the same as an active ingredient, and an intermediate therefor. The compounds (I) of the present invention show a potent PDE IV inhibitory activity as well as an excellent bronchodilating activity, and hence, they are widely useful as a PDE IV inhibitor in the treatment or prophylaxis of allergic inflammatory diseases or organ inflammatory diseases, especially in the treatment or prophylaxis of pulmonary diseases accompanied by airway obstruction such as asthma.

  化合物(I)的公式为：其中A为O，S，CHR1或NR2，R1和R2为H，低烷基，X1和X2为H，卤素，硝基，氰基等，Y1为H，低烷基，Z1和Z2为H，卤素，氰基，羟基，低烷基等，n为2至4的整数，其药学上可接受的盐，制备其的方法，含有其作为活性成分的制药组合物，以及其中间体。本发明的化合物(I)表现出强大的PDE IV抑制活性以及出色的支气管扩张活性，因此，在过敏性炎症性疾病或器官炎症性疾病的治疗或预防中，特别是在伴有气道阻塞的肺部疾病如哮喘的治疗或预防中，它们被广泛地用作PDE IV抑制剂。
• CHEMICAL COMPOUNDS
  申请人：Jones Lyn Howard

  公开号：US20090264425A1

  公开（公告）日：2009-10-22

  This invention relates to biaryl ether derivatives of formula (I) wherein R 1 , R 3 , R 4 , X, W, Y and m are defined in the description, and to compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof.

  本发明涉及公式（I）的二芳基醚衍生物，其中R1、R3、R4、X、W、Y和m在说明中定义，并涉及含有它们的组合物以及这些衍生物的用途。本发明的化合物与酶逆转录酶结合，并且是其调节剂，特别是抑制剂。
• Phenoxypyridine compound
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0028870A1

  公开（公告）日：1981-05-20

  A compound which is 5-trifluoromethyl-2-p-hydroxy- phenoxypyridine or a metal salt. The compound and salts are useful in the preparation of 2-[4-(5-trifluoromethyl- pyridyl-2-oxy) phenoxy]propionic acid and its derivatives, which are useful as herbicides.

  一种 5-三氟甲基-2-对羟基-苯氧基吡啶或其金属盐的化合物，该化合物及其盐类可用于制备 2-[4-(5-三氟甲基-吡啶-2-氧基)苯氧基]丙酸及其衍生物，可用作除草剂。
• 2,3-DISUBSTITUTED PYRIDINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, DRUG COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THE PREPARATION
  申请人：Dainippon Pharmaceutical Co., Ltd.

  公开号：EP1120409A1

  公开（公告）日：2001-08-01

  A compound of the formula (I) wherein A is O, S, CHR1 or NR2, R1 and R2 are H, lower alkyl, X1 and X2 are H, halogen, nitro, cyano, etc., Y1 is H, lower alkyl, Z1 and Z2 are H, halogen, cyano, hydroxy, lower alkyl, etc., and n is an integer of 2 to 4, a pharmaceutically acceptable salt thereof, a process for preparing the same, a pharmaceutical composition containing the same as an active ingredient, and an intermediate therefor. The compounds (I) of the present invention show a potent PDE IV inhibitory activity as well as an excellent bronchodilating activity, and hence, they are widely useful as a PDE IV inhibitor in the treatment or prophylaxis of allergic inflammatory diseases or organ inflammatory diseases, especially in the treatment or prophylaxis of pulmonary diseases accompanied by airway obstruction such as asthma.

  式 (I) 的化合物 其中 A 是 O、S、CHR1 或 NR2，R1 和 R2 是 H、低级烷基，X1 和 X2 是 H、卤素、硝基、氰基等，Y1 是 H、低级烷基，Z1 和 Z2 是 H、卤素、氰基、羟基、低级烷基等，n 是 2 至 4 的整数，其药学上可接受的盐、其制备方法、含有其作为活性成分的药物组合物以及其中间体。本发明的化合物（I）显示出强效的 PDE IV 抑制活性以及优异的支气管扩张活性，因此，作为 PDE IV 抑制剂，它们在治疗或预防过敏性炎症疾病或器官炎症疾病，尤其是治疗或预防伴有气道阻塞的肺部疾病（如哮喘）方面具有广泛的用途。