(E)-3-[3-(4-chloro-3-fluoro-phenyl)-1-(3-chloro-4-methoxy-phenyl)-1H-pyrazol-4-yl]-2-cyano-acrylic acid | 1097120-59-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (E)-3-[3-(4-chloro-3-fluoro-phenyl)-1-(3-chloro-4-methoxy-phenyl)-1H-pyrazol-4-yl]-2-cyano-acrylic acid
• 英文别名: (E)-3-[3-(4-chloro-3-fluorophenyl)-1-(3-chloro-4-methoxyphenyl)pyrazol-4-yl]-2-cyanoprop-2-enoic acid
• CAS: 1097120-59-6
• 化学式: C₂₀H₁₂Cl₂FN₃O₃
• 分子量: 432.238
• InChiKey: OBVJCZRLBLPSAT-WUXMJOGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  88.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  苯磺酰胺 、 (E)-3-[3-(4-chloro-3-fluoro-phenyl)-1-(3-chloro-4-methoxy-phenyl)-1H-pyrazol-4-yl]-2-cyano-acrylic acid 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以14%的产率得到N-{(E)-3-[3-(4-chloro-3-fluoro-phenyl)-1-(3-chloro-4-methoxy-phenyl)-1H-pyrazol-4-yl]-2-cyano-acryloyl}-benzenesulfonamide
  参考文献：
  名称：

  [EN] NOVEL PYRAZOLE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS
  [FR] NOUVEAUX DÉRIVÉS DE PYRAZOLE UTILES COMME MODULATEURS DES CANAUX POTASSIQUES

  摘要：

  该发明涉及一种新型的嘧啶酮衍生物，其化学式为（I），发现其是钾通道的有效调节剂，因此是治疗对钾通道调节敏感的疾病或疾病的有价值候选药物。

  公开号：

  WO2009003921A1

文献信息

• Urea derivative, process for producing the same, and use
  申请人：Kubo Keiji

  公开号：US20070093501A1

  公开（公告）日：2007-04-26

  The present invention provides a urea derivative or a salt thereof, which is useful as a therapeutic agent for thrombosis. The derivative is represented by Formula (I): wherein Cy is an aromatic hydrocarbon group which may be substituted or an aromatic heterocyclic group which may be substituted; R 1 is a hydrogen atom or a hydrocarbon group which may be substituted; V is —C(O)—, —S(O)—, or —S(O) 2 —; W is —N(R 2 )—, —O—, or a bond (wherein R 2 is a hydrogen atom or a hydrocarbon group which may be substituted); X is alkylene which may be substituted; Y is —C(O)—, —S(O)—, or —S(O) 2 —; Z is a bond, a chain hydrocarbon group which may be substituted, or —N═; ring A is a non-aromatic nitrogen-containing heterocyclic ring which may be substituted; ring B is a nitrogen-containing heterocyclic ring which may be substituted; and [Chemical formula 2] , are each independently a single bond or a double bond; provided that R 1 may be bonded to R 2 to form a non-aromatic nitrogen-containing heterocyclic ring and that R 2 may be bonded to a substituent of X to form a non-aromatic nitrogen-containing heterocyclic ring which may be substituted.

  本发明提供一种尿素衍生物或其盐，其作为治疗血栓症的治疗剂是有用的。该衍生物由公式（I）表示：其中，Cy是芳香族羟基烃基或芳香族杂环基，可以被取代；R1是氢原子或可以被取代的碳氢基团；V是-C（O）-，-S（O）-或-S（O）2-；W是-N（R2）-，-O-或键（其中R2是氢原子或可以被取代的碳氢基团）；X是可以被取代的烷基；Y是-C（O）-，-S（O）-或-S（O）2-；Z是键，可以被取代的链烃基团或-N═；环A是非芳香族含氮杂环环，可以被取代；环B是含氮杂环环，可以被取代；而[化学式2]都是单键或双键；但是，R1可以与R2连接形成非芳香族含氮杂环环，而R2可以与X的取代基连接形成可以被取代的非芳香族含氮杂环环。
• NOVEL PYRAZOLE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS
  申请人：Nardi Antonio

  公开号：US20100179203A1

  公开（公告）日：2010-07-15

  This invention relates to novel pyrazole derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.

  本发明涉及新型吡唑衍生物，这些衍生物被发现是钾通道的有效调节剂，因此是治疗对钾通道调节敏感的疾病或疾病的有价值的候选药物。
• UREA DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1695961A1

  公开（公告）日：2006-08-30

  The present invention provides a urea derivative or a salt thereof, which is useful as a therapeutic agent for thrombosis. The derivative is represented by Formula (I): [Chemical formula I] wherein Cy is an aromatic hydrocarbon group which may be substituted or an aromatic heterocyclic group which may be substituted; R1 is a hydrogen atom or a hydrocarbon group which may be substituted; V is -C(O)-, -S(O)-, or -S(O)2-; W is -N(R2)-, -O-, or a bond (wherein R2 is a hydrogen atom or a hydrocarbon group which may be substituted); X is alkylene which may be substituted; Y is -C(O)-, -S(O)-, or -S(O)2-; Z is a bond, a chain hydrocarbon group which may be substituted, or -N=; ring A is a non-aromatic nitrogen-containing heterocyclic ring which may be substituted; ring B is a nitrogen-containing heterocyclic ring which may be substituted; and [Chemical formula 2] ------‾ , ------̲ are each independently a single bond or a double bond; provided that R1 may be bonded to R2 to form a non-aromatic nitrogen-containing heterocyclic ring and that R2 may be bonded to a substituent of X to form a non-aromatic nitrogen-containing heterocyclic ring which may be substituted.

  本发明提供了一种脲衍生物或其盐，可用作血栓形成的治疗剂。该衍生物由式（I）表示： [化学式 I］ 其中 Cy 是可被取代的芳香烃基团或可被取代的芳香杂环基团；R1 是氢原子或可被取代的烃基团；V 是-C(O)-、-S(O)-或-S(O)2-；W 是-N(R2)-、-O-或键（其中 R2 是氢原子或可被取代的烃基团）；X是可被取代的亚烷基；Y是-C(O)-、-S(O)-或-S(O)2-；Z是键、可被取代的链烃基或-N=；环 A是可被取代的非芳香族含氮杂环；环 B是可被取代的含氮杂环；以及 [化学式 2］ ------‾ , ------̲ 各自独立地为单键或双键；但 R1 可与 R2 键合形成非芳香族含氮杂环，R2 可与 X 的取代基键合形成可被取代的非芳香族含氮杂环。
• US7820673B2
  申请人：——

  公开号：US7820673B2

  公开（公告）日：2010-10-26
• [EN] NOVEL PYRAZOLE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRAZOLE UTILES COMME MODULATEURS DES CANAUX POTASSIQUES
  申请人：NEUROSEARCH AS

  公开号：WO2009003921A1

  公开（公告）日：2009-01-08

  This invention relates to novel pyrazole derivatives of formula (I) that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.

  该发明涉及一种新型的嘧啶酮衍生物，其化学式为（I），发现其是钾通道的有效调节剂，因此是治疗对钾通道调节敏感的疾病或疾病的有价值候选药物。