(1S,2R)-6-methoxy-2-(4-(triphenylsilyl)but-1-en-3-yn-2-yl)indan-1-ol | 1245795-85-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (1S,2R)-6-methoxy-2-(4-(triphenylsilyl)but-1-en-3-yn-2-yl)indan-1-ol
• 英文别名: (1S,2R)-6-methoxy-2-(4-triphenylsilylbut-1-en-3-yn-2-yl)-2,3-dihydro-1H-inden-1-ol
• CAS: 1245795-85-0
• 化学式: C₃₂H₂₈O₂Si
• 分子量: 472.659
• InChiKey: STOMPONCMHAIQX-BHYZAODMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.17
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(buta-2,3-dienyl)-5-methoxybenzaldehyde 、 三苯基硅乙炔 在 (S)-(-)-5,5-双(二苯膦基)-4,4-双-1,3-苯并间二氧杂环戊烯 、 acetylacetonatobis(ethylene)rhodium(I) 、 溶剂黄146 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以80%的产率得到(1S,2R)-6-methoxy-2-(4-(triphenylsilyl)but-1-en-3-yn-2-yl)indan-1-ol
  参考文献：
  名称：

  Rhodium-catalyzed enantioselective alkynylative cyclization of allenyl aldehydes with terminal alkynes

  摘要：

  Asymmetric addition of terminal alkynes to allenyl aldehydes took place in the presence of an acetylacetonate complex [Rh(acac)L*] (L* = binap or segphos) as a catalyst to give indanol derivatives in high yields with high regio- and enantioselectivity. The acetylacetonate (acac) ligand on the rhodium is important for the selective formation of the indanol derivatives. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.04.039

文献信息

• Rhodium-catalyzed enantioselective alkynylative cyclization of allenyl aldehydes with terminal alkynes
  作者：Xun-Xiang Guo、Takahiro Sawano、Takahiro Nishimura、Tamio Hayashi

  DOI：10.1016/j.tetasy.2010.04.039

  日期：2010.7

  Asymmetric addition of terminal alkynes to allenyl aldehydes took place in the presence of an acetylacetonate complex [Rh(acac)L*] (L* = binap or segphos) as a catalyst to give indanol derivatives in high yields with high regio- and enantioselectivity. The acetylacetonate (acac) ligand on the rhodium is important for the selective formation of the indanol derivatives. (C) 2010 Elsevier Ltd. All rights reserved.