2-(2-methylbuta-2,3-dienyl)benzaldehyde | 1245795-80-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-methylbuta-2,3-dienyl)benzaldehyde
• CAS: 1245795-80-5
• 化学式: C₁₂H₁₂O
• 分子量: 172.227
• InChiKey: GMYNSYIYJSLPGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(2-methylbuta-2,3-dienyl)benzaldehyde 、 三苯基硅乙炔 在 (S)-(-)-5,5-双(二苯膦基)-4,4-双-1,3-苯并间二氧杂环戊烯 、 acetylacetonatobis(ethylene)rhodium(I) 、 溶剂黄146 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 生成 2-methyl-2-(4-(triphenylsilyl)but-1-en-3-yn-2-yl)indan-1-ol 、 (1R,2S)-2-methyl-2-(4-(triphenylsilyl)but-1-en-3-yn-2-yl)indan-1-ol 、 (1S,2R)-2-methyl-2-(4-(triphenylsilyl)but-1-en-3-yn-2-yl)indan-1-ol 、 2-methyl-2-(4-(triphenylsilyl)but-1-en-3-yn-2-yl)indan-1-ol
  参考文献：
  名称：

  Rhodium-catalyzed enantioselective alkynylative cyclization of allenyl aldehydes with terminal alkynes

  摘要：

  Asymmetric addition of terminal alkynes to allenyl aldehydes took place in the presence of an acetylacetonate complex [Rh(acac)L*] (L* = binap or segphos) as a catalyst to give indanol derivatives in high yields with high regio- and enantioselectivity. The acetylacetonate (acac) ligand on the rhodium is important for the selective formation of the indanol derivatives. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.04.039
• 作为产物：
  描述：

  在 对甲苯磺酸 作用下， 以 丙酮 为溶剂， 反应 5.0h， 生成 2-(2-methylbuta-2,3-dienyl)benzaldehyde
  参考文献：
  名称：

  Rhodium-catalyzed enantioselective alkynylative cyclization of allenyl aldehydes with terminal alkynes

  摘要：

  Asymmetric addition of terminal alkynes to allenyl aldehydes took place in the presence of an acetylacetonate complex [Rh(acac)L*] (L* = binap or segphos) as a catalyst to give indanol derivatives in high yields with high regio- and enantioselectivity. The acetylacetonate (acac) ligand on the rhodium is important for the selective formation of the indanol derivatives. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.04.039

文献信息

• Rhodium-catalyzed enantioselective alkynylative cyclization of allenyl aldehydes with terminal alkynes
  作者：Xun-Xiang Guo、Takahiro Sawano、Takahiro Nishimura、Tamio Hayashi

  DOI：10.1016/j.tetasy.2010.04.039

  日期：2010.7

  Asymmetric addition of terminal alkynes to allenyl aldehydes took place in the presence of an acetylacetonate complex [Rh(acac)L*] (L* = binap or segphos) as a catalyst to give indanol derivatives in high yields with high regio- and enantioselectivity. The acetylacetonate (acac) ligand on the rhodium is important for the selective formation of the indanol derivatives. (C) 2010 Elsevier Ltd. All rights reserved.