ethyl-bis(o-methylphenyl)phosphane | 1085850-86-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl-bis(o-methylphenyl)phosphane
• 英文别名: Ethyl-bis(2-methylphenyl)phosphane
• CAS: 1085850-86-7
• 化学式: C₁₆H₁₉P
• 分子量: 242.301
• InChiKey: OXTKXGVJXOBALA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  dichloro(cycloocta-1,5-diene)palladium (II) 、 ethyl-bis(o-methylphenyl)phosphane 以 乙醚 为溶剂， 以82.9%的产率得到trans-dichlorobis[ethylbis(o-methylphenyl)phosphane]palladium(II)
  参考文献：
  名称：

  Palladium‐Catalyzed Suzuki–Miyaura Cross‐Coupling of Various Aryl Halides Using ortho ‐Alkyl‐Substituted Arylphosphanes and ( ortho ‐Alkylphenyl)alkylphosphanes under Microwave Heating

  摘要：

  AbstractMono‐ and dinuclear palladium(II) chloride complexes of various ortho‐alkyl‐substituted aryl‐ and alkylphosphanes were prepared. Subsequently, these were characterized by 1H NMR and 31P{1H} NMR spectroscopy, X‐ray crystallographic studies and mass spectroscopy. The palladium complexes were screened as potential catalysts for the microwave‐assisted Suzuki–Miyaura coupling reaction of several aryl halides under aerobic conditions. A preliminary study showed that excellent results can be obtained even for electron‐rich bromides and unactivated aryl chlorides with an optimized solvent, base and catalyst loading using specific phosphane ligands. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

  DOI：

  10.1002/ejic.200700705
• 作为产物：
  描述：

  2-溴甲苯 、 乙基二氯化磷 在 正丁基锂 作用下， 以 乙醚 为溶剂， 反应 3.0h， 以89.6%的产率得到ethyl-bis(o-methylphenyl)phosphane
  参考文献：
  名称：

  Palladium‐Catalyzed Suzuki–Miyaura Cross‐Coupling of Various Aryl Halides Using ortho ‐Alkyl‐Substituted Arylphosphanes and ( ortho ‐Alkylphenyl)alkylphosphanes under Microwave Heating

  摘要：

  AbstractMono‐ and dinuclear palladium(II) chloride complexes of various ortho‐alkyl‐substituted aryl‐ and alkylphosphanes were prepared. Subsequently, these were characterized by 1H NMR and 31P{1H} NMR spectroscopy, X‐ray crystallographic studies and mass spectroscopy. The palladium complexes were screened as potential catalysts for the microwave‐assisted Suzuki–Miyaura coupling reaction of several aryl halides under aerobic conditions. A preliminary study showed that excellent results can be obtained even for electron‐rich bromides and unactivated aryl chlorides with an optimized solvent, base and catalyst loading using specific phosphane ligands. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

  DOI：

  10.1002/ejic.200700705

文献信息

• CARBONYLATION PROCESS AND NOVEL TRANSITION METAL CATALYSTS
  申请人：EXXON RESEARCH AND ENGINEERING COMPANY

  公开号：EP0024091A1

  公开（公告）日：1981-02-25
• EP0024091A4
  申请人：——

  公开号：EP0024091A4

  公开（公告）日：1981-07-16
• HYDROFORMYLATION PROCESS AND NOVEL TRANSITION METAL CATALYSTS
  申请人：EXXON RESEARCH AND ENGINEERING COMPANY

  公开号：EP0024091B1

  公开（公告）日：1985-04-03
• US3947503A
  申请人：——

  公开号：US3947503A

  公开（公告）日：1976-03-30
• US4017550A
  申请人：——

  公开号：US4017550A

  公开（公告）日：1977-04-12