Hydrazinyl 4-methylbenzoate | 1026393-29-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Hydrazinyl 4-methylbenzoate
• CAS: 1026393-29-2
• 化学式: C₈H₁₀N₂O₂
• 分子量: 166.18
• InChiKey: IHAYHHMZUDJFMU-UHFFFAOYSA-N

物化性质

• 沸点：
  290.0±33.0 °C(Predicted)
• 密度：
  1.190±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  二硫化碳 、 Hydrazinyl 4-methylbenzoate 在 potassium hydroxide 、 一水合肼 作用下， 以 乙醇 、 水 为溶剂， 生成 4-氨基-5-对甲苯基-4H-[1,2,4]噻唑-3-硫醇
  参考文献：
  名称：

  Synthesis and evaluation of 4-(substituted)-acetylamino-3-mercapto-5-(4-substituted) phenyl-1,2,4-triazole derivatives as antimicrobial agents

  摘要：

  Triazoles and its derivatives are found to possess diverse applications in the field of medicine and industry. A series of novel 1,2,4-triazole derivatives have been synthesized as novel antimicrobial agents starting from different 4-substituted benzoic acids. The chemical structures of these newly synthesized compounds were elucidated by Fourier transform infrared spectroscopy (FTIR), H-1 NMR, C-13 NMR, FAB(+)-MS spectral data, and elemental analysis. Their antimicrobial activities were investigated against four bacterial strains S. aureus (ATCC-25923), P. aeruginosa (ATCC-27853), E. coli (ATCC-8739), B. subtilis (ATCC-6633) and three fungal strains C. albicans (MTCC-227), A. niger (MTCC-3323), and F. oxysporum (MTCC-2087). Preliminary results indicate that some of them exhibit promising activities and deserve further consideration.

  DOI：

  10.1007/s00044-011-9708-z
• 作为产物：
  描述：

  对甲基苯甲酸甲酯 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 Hydrazinyl 4-methylbenzoate
  参考文献：
  名称：

  N'-(芳酰基)-碳二硫代肼的Ni(II)配合物的抗增殖活性和电化学析氧

  摘要：

  过渡金属络合物的电化学水分解正在迅速出现。镍络合物在各种生物活动中也起着非常重要的作用。这里，三个新的配体 {H 2 mbhce = N '-(4-甲基-苯甲酰基)、H 2 pchce = N '-(吡啶-羰基) 和 H 2 hbhce = N '-(2-羟基-苯甲酰基)肼碳二硫酸乙酯}及其相应的Ni( II )配合物[Ni(Hmbhce) 2 (py) 2 ] ( 1 ), [Ni(pchce)( o -phen ) 2 ]·CH 3 OH·H 2 O ( 2) 和[Ni(hbhce)( o -phen ) 2 ]·1.75CHCl 3 ·H 2 O ( 3 ) 已经合成并通过各种物理化学和X射线晶体学技术进行了充分表征。还检查了光致发光研究和热降解。用增加浓度的镍盐、配体和复合物1、2和3处理K562细胞显示出剂量依赖性细胞毒性。配体的细胞毒活性表明，与其他配体 H 2 pbhce 和

  DOI：

  10.1039/d1dt02285g

文献信息

• Antiproliferative activity and electrochemical oxygen evolution by Ni(<scp>ii</scp>) complexes of <i>N</i>′-(aroyl)-hydrazine carbodithioates
  作者：R. Chaurasia、Shivendra Kumar Pandey、Devesh Kumar Singh、M. K. Bharty、Vellaichamy Ganesan、S. K. Hira、P. P. Manna、A. Bharti、Ray J. Butcher

  DOI：10.1039/d1dt02285g

  日期：——

  [Ni(Hmbhce)2(py)2] (1), [Ni(pchce)(o-phen)2]·CH3OH·H2O (2) and [Ni(hbhce)(o-phen)2]·1.75CHCl3·H2O (3) have been synthesized and fully characterized by various physicochemical and X-ray crystallography techniques. The photoluminescence study and thermal degradations were also examined. The treatment of K562 cells with the increasing concentrations of the nickel salts, ligands, and complexes 1, 2, and 3 showed dose-dependent

  过渡金属络合物的电化学水分解正在迅速出现。镍络合物在各种生物活动中也起着非常重要的作用。这里，三个新的配体 H 2 mbhce = N '-(4-甲基-苯甲酰基)、H 2 pchce = N '-(吡啶-羰基) 和 H 2 hbhce = N '-(2-羟基-苯甲酰基)肼碳二硫酸乙酯}及其相应的Ni( II )配合物[Ni(Hmbhce) 2 (py) 2 ] ( 1 ), [Ni(pchce)( o -phen ) 2 ]·CH 3 OH·H 2 O ( 2) 和[Ni(hbhce)( o -phen ) 2 ]·1.75CHCl 3 ·H 2 O ( 3 ) 已经合成并通过各种物理化学和X射线晶体学技术进行了充分表征。还检查了光致发光研究和热降解。用增加浓度的镍盐、配体和复合物1、2和3处理K562细胞显示出剂量依赖性细胞毒性。配体的细胞毒活性表明，与其他配体 H 2 pbhce 和
• Synthesis and evaluation of 4-(substituted)-acetylamino-3-mercapto-5-(4-substituted) phenyl-1,2,4-triazole derivatives as antimicrobial agents
  作者：Neeraj Upmanyu、Sanjay Kumar、Pawan Porwal、Kamal Shah、Pradeep Mishra

  DOI：10.1007/s00044-011-9708-z

  日期：2012.8

  Triazoles and its derivatives are found to possess diverse applications in the field of medicine and industry. A series of novel 1,2,4-triazole derivatives have been synthesized as novel antimicrobial agents starting from different 4-substituted benzoic acids. The chemical structures of these newly synthesized compounds were elucidated by Fourier transform infrared spectroscopy (FTIR), H-1 NMR, C-13 NMR, FAB(+)-MS spectral data, and elemental analysis. Their antimicrobial activities were investigated against four bacterial strains S. aureus (ATCC-25923), P. aeruginosa (ATCC-27853), E. coli (ATCC-8739), B. subtilis (ATCC-6633) and three fungal strains C. albicans (MTCC-227), A. niger (MTCC-3323), and F. oxysporum (MTCC-2087). Preliminary results indicate that some of them exhibit promising activities and deserve further consideration.