5-[4,5-bis(4-fluorophenyl)-1H-imidazol-2-yl]-2-methoxyphenol | 384357-93-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-[4,5-bis(4-fluorophenyl)-1H-imidazol-2-yl]-2-methoxyphenol
• CAS: 384357-93-1
• 化学式: C₂₂H₁₆F₂N₂O₂
• 分子量: 378.378
• InChiKey: ZPEQMWVRDJWJFO-UHFFFAOYSA-N

物化性质

• 熔点：
  218-220 °C(Solv: acetone (67-64-1); water (7732-18-5))
• 沸点：
  578.1±50.0 °C(Predicted)
• 密度：
  1.315±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  58.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  异香兰素 、 4,4'-二氟苯偶酰 在 ammonium acetate 、 magnesium oxide 作用下， 反应 0.5h， 以97%的产率得到5-[4,5-bis(4-fluorophenyl)-1H-imidazol-2-yl]-2-methoxyphenol
  参考文献：
  名称：

  纳米晶氧化镁：一种新型高效合成催化剂，可轻松合成2,4,5-三取代的咪唑衍生物

  摘要：

  摘要具有高比表面积的纳米晶氧化镁已被用作新型，有效的催化剂，用于通过三组分一锅缩合的1,2-二酮来改进和快速合成具有生物活性的2,4,5-三取代的咪唑和芳基醛，在无溶剂和常规加热条件下，收率极高。该方法具有多个优点，例如优异的产率，较短的反应时间以及使用无毒且可回收的催化剂。 图形概要

  DOI：

  10.1007/s00706-010-0397-y

文献信息

• A highly efficient magnetic solid acid catalyst for synthesis of 2,4,5-trisubstituted imidazoles under ultrasound irradiation
  作者：Javad Safari、Zohre Zarnegar

  DOI：10.1016/j.ultsonch.2012.10.004

  日期：2013.3

  Fe3O4 nanoparticles were prepared by chemical coprecipitation method and subsequently coated with 3-aminopropyltriethoxysilane (APTES) via silanization reaction. Grafting of chlorosulfuric acid on the amino-functionalized Fe3O4 nanoparticles afforded sulfamic acid-functionalized magnetic nanoparticles (SA-MNPs). SA-MNPs was found to be a mild and effective solid acid catalyst for the efficient, one-pot, three-component synthesis of 2,4,5-trisubstituted imidazoles under ultrasound irradiation. This protocol afforded corresponding imidazoles in shorter reaction durations, and in high yields. This green procedure has many obvious advantages compared to those reported in the previous literatures, including avoiding the use of harmful catalysts, easy and quick isolation of the products, excellent yields, short routine, and simplicity of the methodology. (C) 2012 Elsevier B.V. All rights reserved.
• Nanocrystalline magnesium oxide: a novel and efficient catalyst for facile synthesis of 2,4,5-trisubstituted imidazole derivatives
  作者：Javad Safari、Shiva Dehghan Khalili、Mehran Rezaei、Sayed Hossein Banitaba、Fereshteh Meshkani

  DOI：10.1007/s00706-010-0397-y

  日期：2010.12

  area has been used as a novel and efficient catalyst for an improved and rapid synthesis of biologically active 2,4,5-trisubstituted imidazoles, by three-component, one-pot condensation of 1,2-diketones and aryl aldehydes, in excellent yields under solvent-free and conventional heating conditions. The method has several advantages, for example excellent yields, shorter reaction time, and use of a non-toxic

  摘要具有高比表面积的纳米晶氧化镁已被用作新型，有效的催化剂，用于通过三组分一锅缩合的1,2-二酮来改进和快速合成具有生物活性的2,4,5-三取代的咪唑和芳基醛，在无溶剂和常规加热条件下，收率极高。该方法具有多个优点，例如优异的产率，较短的反应时间以及使用无毒且可回收的催化剂。 图形概要