N^α-tetradecanoyl-histidine | 133849-43-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N^α-tetradecanoyl-histidine
• 英文别名: N-Myristoyl Histidine；3-(1H-imidazol-5-yl)-2-(tetradecanoylamino)propanoic acid
• CAS: 133849-43-1
• 化学式: C₂₀H₃₅N₃O₃
• 分子量: 365.516
• InChiKey: OFYZXDHFDCJNGQ-UHFFFAOYSA-N

物化性质

• 沸点：
  623.3±50.0 °C(Predicted)
• 密度：
  1.067±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  26
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  95.1
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  肉豆蔻酰氯 、 D,L-histidine 生成 N^α-tetradecanoyl-histidine
  参考文献：
  名称：

  Effect of cholesterol on the stereoselective hydrolysis in artificial membrane systems

  摘要：

  DOI：

  10.1021/jo00194a019

文献信息

• COMPOSITION FOR EXTERNAL APPLICATION
  申请人：Rohto Pharmaceutical Co., Ltd.

  公开号：EP3210613A1

  公开（公告）日：2017-08-30

  An object of the present invention is to provide an external use composition having a novel composition that has a superior effect promoting collagen production and is able to suppress, prevent or improve wrinkles and sagging of the skin with aging. The present invention relates to an external use composition for anti-aging, comprising (A) a lipopeptide represented by the following formula (1), or a pharmaceutically acceptable salt thereof: (wherein, R1 represents a saturated aliphatic group, or aliphatic group having a single unsaturated bond, having 9 to 19 carbon atoms, and m represents 0 or 1).

  本发明的目的是提供一种外用组合物，该组合物具有新颖的成分，具有促进胶原蛋白生成的卓越效果，能够抑制、预防或改善随着衰老而出现的皱纹和皮肤松弛。 本发明涉及一种用于抗衰老的外用组合物，其中包括 (A) 下式（1）代表的脂肽或其药学上可接受的盐： (其中，R1 代表具有 9 至 19 个碳原子的饱和脂肪族基团或具有单个不饱和键的脂肪族基团，m 代表 0 或 1）。
• Composition for external application
  申请人：ROHTO PHARMACEUTICAL CO., LTD.

  公开号：US10835572B2

  公开（公告）日：2020-11-17

  An object of the present invention is to provide an external use composition having a novel composition that has a superior effect promoting collagen production and is able to suppress, prevent or improve wrinkles and sagging of the skin with aging. The present invention relates to an external use composition for anti-aging, comprising (A) a lipopeptide represented by the following formula (1), or a pharmaceutically acceptable salt thereof: (wherein, R1 represents a saturated aliphatic group, or aliphatic group having a single unsaturated bond, having 9 to 19 carbon atoms, and m represents 0 or 1).

  本发明的目的是提供一种外用组合物，该组合物具有新颖的成分，具有促进胶原蛋白生成的卓越效果，能够抑制、预防或改善随着衰老而出现的皱纹和皮肤松弛。 本发明涉及一种用于抗衰老的外用组合物，其中包括 (A) 下式（1）代表的脂肽或其药学上可接受的盐： (其中，R1 代表饱和脂肪族基团，或具有单个不饱和键的脂肪族基团，具有 9 至 19 个碳原子，m 代表 0 或 1）。
• AN ENZYME-CATALYZED PROCESS FOR PREPARING N-ACYL AMINO ACIDS AND N-ACYL AMINO ACID AMIDES
  申请人：NOVO NORDISK A/S

  公开号：EP0473700A1

  公开（公告）日：1992-03-11
• Composition for External Application
  申请人：ROHTO PHARMACEUTICAL CO., LTD.

  公开号：US20170209522A1

  公开（公告）日：2017-07-27

  An object of the present invention is to provide an external use composition having a novel composition that has a superior effect promoting collagen production and is able to suppress, prevent or improve wrinkles and sagging of the skin with aging. The present invention relates to an external use composition for anti-aging, comprising (A) a lipopeptide represented by the following formula (1), or a pharmaceutically acceptable salt thereof: (wherein, R 1 represents a saturated aliphatic group, or aliphatic group having a single unsaturated bond, having 9 to 19 carbon atoms, and m represents 0 or 1).
• [EN] AN ENZYME-CATALYZED PROCESS FOR PREPARING N-ACYL AMINO ACIDS AND N-ACYL AMINO ACID AMIDES
  申请人：NOVO NORDISK A/S

  公开号：WO1990014429A1

  公开（公告）日：1990-11-29

  (EN) Compounds of general formula (I) or (II), wherein R is an optionally substituted alkyl group with 3-23 carbon atoms, and R1 is hydrogen or an optionally substituted branched or straight-chain, saturated or unsaturated, aliphatic or aromatic hydrocarbon group, are prepared by reacting a compound of the general formula (III): RCOOR2, wherein R2 is H or an alkyl group with 1-6 carbon atoms, and R is as defined above, with a compound of general formula (IV), wherein R1 is as defined above, in the presence of an enzyme capable of catalysing the formation of amide bonds, in particular a lipase. The amide group may be removed from the compound (I) by means of a second enzyme capable of selectively cleaving amide bonds, e.g. a carboxypeptidase, resulting in the compound (II).(FR) Des composés de formule générale (I) ou (II), où R est un groupe alcoyle substitué ou non ayant 3-23 atomes de carbone et R1 est l'hydrogène ou un groupe substitué ou non, à chaîne linéaire ou ramifiée d'hydrocarbures aliphatiques ou aromatiques, saturés ou non saturés, sont préparés en faisant réagir un composé de formule générale (II) où R2 est H ou un groupe alcoyle ayant 1-6 atomes de carbone et R correspond à la définition ce-dessus, avec un composé de formule générale (IV) où R est comme défini ci-dessus, en présence d'une enzyme pouvant catalyser la formation de liaisons d'amides, en particulier, une lipase. On peut extraire le groupe amide présent dans le composé (I) à l'aide d'une deuxième enzyme pouvant cliver les liaisons d'amides, par exemple, une carboxypeptidase, ainsi réalisant le composé (II).