tert-butyl (2S,3R)-1-(ethylamino)-3-hydroxy-1-oxobutan-2-ylcarbamate | 439151-49-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl (2S,3R)-1-(ethylamino)-3-hydroxy-1-oxobutan-2-ylcarbamate
• 英文别名: Boc-L-Thr-NH-Et；tert-butyl N-[(2S,3R)-1-(ethylamino)-3-hydroxy-1-oxobutan-2-yl]carbamate
• CAS: 439151-49-2
• 化学式: C₁₁H₂₂N₂O₄
• 分子量: 246.307
• InChiKey: UHTIGFWSXJYIFZ-SFYZADRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  87.7
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl (2S,3R)-1-(ethylamino)-3-hydroxy-1-oxobutan-2-ylcarbamate 在 盐酸 、 氯化亚砜 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 甲醇 、 二氯甲烷 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  LANTHANIDE CLUSTERS AND METHODS OF USE THEREOF

  摘要：

  本发明涉及基于苯基-噁唑啉酰胺（POxA）配体的多核镧系手性簇以及其使用方法。本发明的手性簇具有高荧光性能和高稳定性。

  公开号：

  US20160002269A1
• 作为产物：
  描述：

  Boc-L-苏氨酸 、 乙胺 在 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 以89.25%的产率得到tert-butyl (2S,3R)-1-(ethylamino)-3-hydroxy-1-oxobutan-2-ylcarbamate
  参考文献：
  名称：

  LANTHANIDE CLUSTERS AND METHODS OF USE THEREOF

  摘要：

  本发明涉及基于苯基-噁唑啉酰胺（POxA）配体的多核镧系手性簇以及其使用方法。本发明的手性簇具有高荧光性能和高稳定性。

  公开号：

  US20160002269A1

文献信息

• DIAMINE CROSSLINKING AGENTS, CROSSLINKED ACIDIC POLYSACCHARIDES AND MEDICAL MATERIALS
  申请人：Seikagaku Corporation

  公开号：US20170001948A1

  公开（公告）日：2017-01-05

  The invention provides a diamine crosslinking agent for acidic polysaccharides consisting of a diamine compound having a primary amino group at both terminals and an ester or thioester bond in the molecule, wherein the number of atom in the linear chain between at least one of the amino groups and the carbonyl carbon in the ester or thioester is 1 to 5; in particular, a diamine crosslinking agent for acidic polysaccharides which is represented by the general formula (I) below: [the symbols in the formula are as described in the specification]; a crosslinked acidic polysaccharide obtained by forming crosslinks by amide bonding between the amino groups in the diamine crosslinking agent and carboxyl groups in an acidic polysaccharide; and a medical material including the crosslinked product.

  该发明提供了一种用于酸性多糖的二胺交联剂，其由一种二胺化合物组成，该化合物在分子中的两个末端具有主要氨基团，并且在至少一个氨基团与酯或硫酯中的羰基碳之间的线性链中的原子数为1至5；特别是一种用下面的通式(I)表示的酸性多糖的二胺交联剂： [式中的符号如说明书中所述]；通过在二胺交联剂的氨基团和酸性多糖中的羧基团之间形成酰胺键而获得的交联酸性多糖；以及包括所述交联产物的医用材料。
• Diamine crosslinking agents, crosslinked acidic polysaccharides and medical materials
  申请人：Seikagaku Corporation

  公开号：US10919840B2

  公开（公告）日：2021-02-16

  The invention provides a diamine crosslinking agent for acidic polysaccharides consisting of a diamine compound having a primary amino group at both terminals and an ester or thioester bond in the molecule, wherein the number of atom in the linear chain between at least one of the amino groups and the carbonyl carbon in the ester or thioester is 1 to 5; in particular, a diamine crosslinking agent for acidic polysaccharides which is represented by the general formula (I) below: [the symbols in the formula are as described in the specification]; a crosslinked acidic polysaccharide obtained by forming crosslinks by amide bonding between the amino groups in the diamine crosslinking agent and carboxyl groups in an acidic polysaccharide; and a medical material including the crosslinked product.

  本发明提供了一种用于酸性多糖的二胺交联剂，该交联剂由二胺化合物组成，该二胺化合物的两个末端均有伯氨基，分子中具有酯键或硫酯键，其中至少一个氨基与酯键或硫酯键中的羰基碳之间的线性链上的原子数为 1 至 5；特别是一种用于酸性多糖的二胺交联剂，该交联剂由以下通式（I）表示： [式中符号如说明书所述]；通过二胺交联剂中的氨基与酸性多糖中的羧基之间的酰胺键形成交联而获得的交联酸性多糖；以及包括交联产物的医用材料。
• Capped diaminopropionamide–glycine dipeptides are inhibitors of CC chemokine receptor 2 (CCR2)
  作者：Percy H. Carter、Gregory D. Brown、Sarah R. Friedrich、Robert J. Cherney、Andrew J. Tebben、Yvonne C. Lo、Gengjie Yang、Heather Jezak、Kimberly A. Solomon、Peggy A. Scherle、Carl P. Decicco

  DOI：10.1016/j.bmcl.2007.07.028

  日期：2007.10

  A new series of CCR2 antagonists has been discovered that incorporates intramolecular hydrogen bonding as a strategy for rigidifying the scaffold. The structure-activity relationship was established through initial systematic modification of substitution pattern and chain length, followed by independent optimization of three different substituents (benzylamine, carboxamide, and benzamide). Several of the acyclic compounds display 10-30 nM binding affinity for CCR2. Moreover, these antagonists are able to block both MCP-1-induced Ca2+ flux and monocyte chemotaxis, and are selective for binding to CCR2 over CCR1 and CCR3. (C) 2007 Elsevier Ltd. All rights reserved.
• DIAMINE CROSSLINKING AGENT, ACIDIC POLYSACCHARIDE CROSSLINKED BODY, AND MEDICAL MATERIAL
  申请人：Seikagaku Corporation

  公开号：EP3101064B1

  公开（公告）日：2020-07-15
• LANTHANIDE CLUSTERS AND METHODS OF USE THEREOF
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US20160002269A1

  公开（公告）日：2016-01-07

  The present invention is directed to multinuclear lanthanides chiral clusters, based on phenyl-oxazoline-amide (POxA) ligands, and to methods of use thereof. The chiral clusters of this invention are highly fluorescent with high stability.

  本发明涉及基于苯基-噁唑啉酰胺（POxA）配体的多核镧系手性簇以及其使用方法。本发明的手性簇具有高荧光性能和高稳定性。