(2-(ethylamino)-5-phenylfuran-3-yl)(4-methoxyphenyl)methanone | 1293365-35-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2-(ethylamino)-5-phenylfuran-3-yl)(4-methoxyphenyl)methanone
• 英文别名: [2-(Ethylamino)-5-phenylfuran-3-yl]-(4-methoxyphenyl)methanone；[2-(ethylamino)-5-phenylfuran-3-yl]-(4-methoxyphenyl)methanone
• CAS: 1293365-35-1
• 化学式: C₂₀H₁₉NO₃
• 分子量: 321.376
• InChiKey: SOJKFZRHQDOYHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  51.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苄基三苯基氯化膦 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 乙醇 、 二氯甲烷 、 水 、 乙腈 为溶剂， 反应 25.08h， 生成 (2-(ethylamino)-5-phenylfuran-3-yl)(4-methoxyphenyl)methanone
  参考文献：
  名称：

  Synthesis of 2,3,5-trisubstituted furans from α-formylaroylketene dithioacetals

  摘要：

  A new strategy for the synthesis of 2,3,5-trisbustituted furans from alpha-formylketene dithioacetals is described. The protocol involves a facile conversion of alpha-formylketene dithioacetals to vinylketene dithioacetals via Wittig reaction and subsequent N-bromosuccinimide-mediated cyclization to 2,3,5-trisbustituted furans. Further conversion of the 2-thioalkylfurans thus obtained to 2-aminofurans shows the potential synthetic utility of this new approach. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.128

文献信息

• Synthesis of 2,3,5-trisubstituted furans from α-formylaroylketene dithioacetals
  作者：K.A. Sasikala、K.A. Kalesh、E.R. Anabha、P. Madhavan Pillai、C.V. Asokan、K.S. Devaky

  DOI：10.1016/j.tetlet.2011.01.128

  日期：2011.4

  A new strategy for the synthesis of 2,3,5-trisbustituted furans from alpha-formylketene dithioacetals is described. The protocol involves a facile conversion of alpha-formylketene dithioacetals to vinylketene dithioacetals via Wittig reaction and subsequent N-bromosuccinimide-mediated cyclization to 2,3,5-trisbustituted furans. Further conversion of the 2-thioalkylfurans thus obtained to 2-aminofurans shows the potential synthetic utility of this new approach. (c) 2011 Elsevier Ltd. All rights reserved.