11-phenylsulfanyl-undecanoic acid | 4230-10-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 11-phenylsulfanyl-undecanoic acid
• 英文别名: 11-Phenylmercapto-undecansaeure；11-Phenyl-mercapto-undecansaeure；11-(Phenylthio)undecanoic acid；11-phenylsulfanylundecanoic acid
• CAS: 4230-10-8
• 化学式: C₁₇H₂₆O₂S
• 分子量: 294.458
• InChiKey: BPYSWIMKOZCXIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  11-phenylsulfanyl-undecanoic acid 在 过氧乙酸 、 溶剂黄146 作用下， 生成 11-benzenesulfonyl-undecanoic acid
  参考文献：
  名称：

  Organic Sulfur Derivatives. II.² Sulfides, Sulfoxides and Sulfones from Thiols and 10-Undecenoic Acid

  摘要：

  DOI：

  10.1021/ja01572a067
• 作为产物：
  描述：

  2-十一烯酸 、 苯硫酚 以 二氯甲烷 、 水 为溶剂， 以61 %的产率得到11-phenylsulfanyl-undecanoic acid
  参考文献：
  名称：

  紫光促进烯烃的硫醇烯反应

  摘要：

  在这里，我们提出了一种用于紫光介导的烯烃与硫醇的抗马可夫尼科夫官能化的无催化剂方案。硫基自由基的产生至关重要的是关键光活性络合物的形成。获得了 30 多种硫醚产品，证明了对不同官能团的耐受性以及高达 5 mmol 烯烃的可扩展性。已经开发了两种不同的反应条件，改变溶剂和硫醇的量。根据烯烃结构，水可以替代二氯甲烷作为溶剂，从而提高整个过程的可持续性。

  DOI：

  10.1002/adsc.202300990

文献信息

• Particulate construct comprising polyhydroxyalkanoate and method for producing it
  申请人：——

  公开号：US20030194443A1

  公开（公告）日：2003-10-16

  The invention provides a particulate construct such as microcapsules containing a drug, and serving a slow releasing preparation not associated with a practically unacceptable initial burst release but showing a practically acceptable zero-order release for a certain period and a producing method for such particulate construct, and a slow releasing preparation of a high drug content capable of stably incorporating the drug in the particulate construct such as microcapsules, and a producing method for such preparation. The invention also provides a particulate construct such as microcapsules utilizing a highly functional polymer compound and incorporating oil phase and/or water phase in solid phase, and a producing method therefor. Furthermore, the invention provides a particulate construct such as microcapsules having a hollow structure of a single polymer membrane as the outer shell and capable of containing many bubbles in the fine particles, and a producing method capable of preparing such construct with a high reproducibility. According to the invention, a particulate construct such as microcapsules is formed with polyhydroxyalkanoate of a specified structure and a drug for a desired purpose, an oil phase and/or a water phase, or a gaseous phase is included in such construct.

  本发明提供了一种微粒构造物，例如包含药物的微胶囊，用作缓释制剂，不会出现实际上不可接受的初始爆发释放，但在一定时间内显示实际上可接受的零级释放，并提供了这种微粒构造物的制备方法，以及能够稳定地将药物纳入微粒构造物中，例如微胶囊的高药物含量的缓释制剂，以及这种制备方法。本发明还提供了一种利用高功能聚合物化合物并将油相和/或水相纳入固相的微粒构造物，以及其制备方法。此外，本发明还提供了一种具有单一聚合物膜的空心结构的微粒构造物，能够在细小的颗粒中包含许多气泡，并提供了一种能够高度重复制备这种构造物的制备方法。根据本发明，可使用具有特定结构的聚羟基烷酸酯和药物制备微粒构造物，该构造物中包含油相和/或水相或气态相。
• Polyhydroxyalkanoate-containing magnetic structure, and manufacturing method and use thereof
  申请人：Yano Tetsuya

  公开号：US20060263432A1

  公开（公告）日：2006-11-23

  A structure containing polyhydroxyalkanoate and a magnetic substance includes an external phase part containing polyhydroxyalkanoate and an internal phase part contained in the external phase part, at least one of the external phase part and the internal phase part containing a magnetic substance. Accordingly, provided is a microcapsule, which can be suitably used for formation of an active ingredient of a sustained release pharmaceutical preparation or an ultrasonic contrast agent.

  一种含有聚羟基脂肪酸酯和磁性物质的结构，包括一个包含聚羟基脂肪酸酯的外相部分和一个包含在外相部分中的内相部分，其中至少一个外相部分和内相部分含有磁性物质。因此，提供了一种微胶囊，可适用于制备持续释放药物制剂或超声造影剂的活性成分。
• Polyhydroxyalkanoate containing unit with thienyl structure in the side chain, process for its production, charge control agent, toner binder and toner which contain this polyhydroxyalkanoate, and image-forming method and image-forming apparatus which make use of the toner
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP1245605A2

  公开（公告）日：2002-10-02

  A polyhydroxyalkanoate characterized by having in the molecule a unit represented by Chemical Formula (1) :    wherein n may assume any one integral value within the range of from 1 to 8. Also disclosed are a process for producing the polyhydroxyalkanoate by the use of a microorganism having the ability to produce the polyhydroxyalkanoate and accumulate it in the bacterial body; a charge control agent, a toner binder and a toner which contain this polyhydroxyalkanoate; and an image-forming method and an image-forming apparatus which make use of the toner.

  一种聚羟基烷酸酯，其特征在于分子中具有由化学式（1）表示的单元： 其中 n 可取 1 至 8 范围内的任意一个整数值。 本发明还公开了一种生产聚羟基烷酸酯的工艺，该工艺使用的微生物具有生产聚羟基烷酸酯并将其积聚在细菌体内的能力；一种电荷控制剂、一种墨粉粘合剂和一种墨粉，其中含有这种聚羟基烷酸酯；以及一种图像形成方法和一种图像形成装置，其中使用了该墨粉。
• Novel polyhydroxyalkanoate containing unit phenylsulfanyl structure in the side cahin, process for its production, charge control agent, toner binder and toner which contain novel polyhydroxyalkanoate, and imageforming apparatus which make use of the toner
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP1236755A2

  公开（公告）日：2002-09-04

  A polyhydroxyalkanoate is disclosed which has in the molecule a unit represented by Chemical Formula (1). wherein R is arbitrarily selected from a hydrogen atom, a halogen atom, CN, NO2, COOR', SO2R", CH3, C2H5, C3H7, C(CH3)2H and C(CH3)3; where R' is H, Na, K, CH3 or C2H5, and R" is OH, ONa, OK, a halogen atom, OCH3 or OC2H5; and x is an integer arbitrarily selected from 1 to 8; with the proviso that a polyhydroxyalkanoate is excluded which has a hydrogen atom as R and x in all the units is 2 or 4. Also disclosed is a process for producing the polyhydroxyalkanoate by the use of a microorganism having the ability to produce the polyhydroxyalkanoate and accumulate it in the bacterial body.

  本发明公开了一种聚羟基烷酸酯，其分子中具有化学式（1）所代表的单元。 其中 R 可任意选自氢原子、卤素原子、CN、NO2、COOR'、SO2R"、CH3、C2H5、C3H7、C(CH3)2H 和 C(CH3)3；其中 R'是 H、Na、K、CH3 或 C2H5，R "是 OH、ONa、OK、卤素原子、OCH3 或 OC2H5；x 是任意选自 1 至 8 的整数；但不包括以氢原子作为 R 且所有单元中 x 为 2 或 4 的聚羟基烷酸酯。本发明还公开了一种生产聚羟基烷酸的工艺，使用的微生物具有生产聚羟基烷酸并在细菌体内积累的能力。
• Novel polyhydroxyalkanoate that comprises unit having substituted or unsubstituted (phenylmethyl) sulfanyl structure in side chain thereof and process for producing the same
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP1262508A2

  公开（公告）日：2002-12-04

  A polyhydroxyalkanoate that comprises a unit represented by the following chemical formula (1): wherein R1 is a substituent of an aromatic ring selected from the group consisting of H, CH3, C2H5, CH3CH2CH2, (CH3)2CH, (CH3)3C, a halogen atom, CN, NO2, COOR', and SO2R", wherein R' is selected from the group consisting of H, Na, K, CH3, and C2H5, and R" is selected from the group consisting of OH, a halogen atom, ONa, OK, OCH3, and OC2H5; and x represents an integer of 1 to 8 being the same or different each other in the polyhydroxyalkanoate. A method for producing the polyhydroxyalkanoate is also provided.

  一种聚羟基烷酸酯，由以下化学式(1)代表的单元组成： 其中 R1 是芳香环的取代基，选自由 H、CH3、C2H5、CH3CH2CH2、(CH3)2CH、(CH3)3C、卤素原子、CN、NO2、COOR'和 SO2R "组成的组，其中 R'选自由 H、Na、K、CH3 和 C2H5 组成的组，R "选自由 OH、卤素原子、ONa、OK、OCH3 和 OC2H5 组成的组；和 x 代表在聚羟基烷酸酯中相同或互不相同的 1 至 8 的整数。还提供了一种生产聚羟基烷酸酯的方法。