4-hydroxy-N-laurylbutyramide | 10395-23-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-hydroxy-N-laurylbutyramide
• 英文别名: 4-hydroxy-butyric acid dodecylamide；N-Dodecyl-4-hydroxy-butyramid；4-Hydroxy-buttersaeure-dodecylamid；N-DODECYL-4-HYDROXYBUTYRAMIDE；N-dodecyl-4-hydroxybutanamide
• CAS: 10395-23-0
• 化学式: C₁₆H₃₃NO₂
• 分子量: 271.444
• InChiKey: XDLZKXFUWLXBCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-hydroxy-N-laurylbutyramide 在 吡啶 、 氯化亚砜 作用下， 以 苯 为溶剂， 生成 4-CHLORO-N-DODECYLBUTYRAMIDE
  参考文献：
  名称：

  Carboxylic amides as fungicides to eumycotina in phanerogamia plant life

  摘要：

  本发明涉及使用具有以下结构的一个或多个取代羧酸酰胺来控制和/或根除被子植物中的真菌：其中A是由2至14个碳原子组成的有机基，选择自羟基烷基、羟基烷氧基、卤代烷基基团和具有结构--R.sub.1--O--R.sub.2--的取代烷醚基团，其中R.sub.1是由1至6个碳原子组成的烷基，R.sub.2是由1至6个碳原子组成的烷基，取代有羟基、羧酸酯或卤代羧酸酯基团；R是一个非环烷基基团，一个含有一个或多个双键碳原子的烯基基团，一个单-或双-氟代苄基基团或一个单-或双-氯代苄基基团，所述的R基团含有从4至20个碳原子。该发明还涉及在被子植物上使用具有真菌毒性量的羧酸酰胺或羧酸酰胺混合物的方法，以控制或根除真菌感染。

  公开号：

  US04195096A1
• 作为产物：
  描述：

  γ-丁内酯 、 十二烷基伯胺 反应 8.0h， 生成 4-hydroxy-N-laurylbutyramide
  参考文献：
  名称：

  COSMETIC BASE INCLUDING AMIDE ALCOHOL, AND COSMETIC

  摘要：

  本发明的目的是提供一种可用作化妆品基础成分的新型酰胺醇。一种由式（I）所表示的酰胺醇。

  公开号：

  US20190343745A1

文献信息

• NOVEL COMPLEX AND EMULSION COMPOSITION
  申请人：Kokyu Alcohol Kogyo Co., Ltd.

  公开号：EP3479816A1

  公开（公告）日：2019-05-08

  [Problem] An object of the invention is to provide a novel complex that can be used as an emulsifier. [Solving means] A complex in which an amide alcohol and a carboxyl group-containing polymer exerts an excellent emulsifying power for oil having a wide range of required HLB.

  [问题] 本发明的目的是提供一种可用作乳化剂的新型复合物。 [解决方法]一种酰胺醇和含羧基聚合物的复合物对具有广泛 HLB 要求的油类具有极佳的乳化能力。
• Complex and emulsion composition
  申请人：Kokyu Alcohol Kogyo Co., Ltd.

  公开号：US10729629B2

  公开（公告）日：2020-08-04

  [Problem] An object of the invention is to provide a novel complex that can be used as an emulsifier. [Solving means] A complex in which an amide alcohol and a carboxyl group-containing polymer exerts an excellent emulsifying power for oil having a wide range of required HLB.

  [问题] 本发明的目的是提供一种可用作乳化剂的新型复合物。 [解决方法]一种酰胺醇和含羧基聚合物的复合物对具有广泛 HLB 要求的油类具有极佳的乳化能力。
• Cosmetic base including amide alcohol, and cosmetic
  申请人：Kokyu Alcohol Kogyo Co., Ltd.

  公开号：US11083677B2

  公开（公告）日：2021-08-10

  The purpose of the present invention is to provide a novel amide alcohol that can be used as a cosmetic base ingredient. An amide alcohol represented by formula (I).

  本发明的目的是提供一种可用作化妆品基础成分的新型酰胺醇。由式（I）代表的酰胺醇。
• Phase Transition in Adsorption Layers at the Air−Water Interface:  Bridging to Langmuir Monolayers
  作者：D. Vollhardt、V. Melzer

  DOI：10.1021/jp963057+

  日期：1997.4.1

  Adsorption layers of aqueous solutions of the amphiphile N-dodecyl-gamma-hydroxybutyric acid amide are investigated using Brewster angle microscopy (BAM) and surface pressure (pi) measurements. The experimental conditions for the occurrence of a first-order phase transition in adsorption layers (Gibbs monolayers) are studied. This phase transition is indicated by an inflection point in the pi-t adsorption kinetics and the evolution of the condensed phase structures whose the morphological features are visualized by BAM. Langmuir monolayers of this amphiphile can be obtained by the usual monolayer technique and are compared with the adsorption layers. The pi-A isotherms of the Langmuir monolayers show the plateau region that corresponds to the two-phase coexistence region for the main transition between a fluid phase of low density and a condensed phase. The critical surface pressures for the main phase transitions in the adsorption layers and Langmuir monolayers are correlated. The morphological features of the condensed phase structures of the Langmuir monolayers and adsorption layers agree completely.
• Reppe et al., Justus Liebigs Annalen der Chemie, 1955, vol. 596, p. 1,200
  作者：Reppe et al.

  DOI：——

  日期：——