butyl 3-(dibutylamino)propanoate | 1432745-55-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: butyl 3-(dibutylamino)propanoate
• CAS: 1432745-55-5
• 化学式: C₁₅H₃₁NO₂
• 分子量: 257.417
• InChiKey: PYEBVYNDGQMXNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丙烯酸丁酯 、 二正丁胺 在 1,3-双(2,6-二-异丙基苯基)咪唑-2-亚基金(I)氯化物 、 silver trifluoromethanesulfonate 作用下， 以 甲苯 为溶剂， 反应 26.0h， 以90%的产率得到butyl 3-(dibutylamino)propanoate
  参考文献：
  名称：

  使用可回收金催化剂进行活化烯烃的分子间单氢胺化和二氢胺化

  摘要：

  氯化金有机金属络合物和银盐的组合用于催化活化烯烃的分子间加氢胺化，即氮杂-迈克尔反应。研究了活化烯烃与氮底物的金催化反应，发现可以提供各种单氢胺化和二氢胺化产物，后者是罕见的和原始的。快速色谱后，金 NHC 催化剂可以作为氢氧化金 NHC 复合物回收。当与银盐结合时，金络合物再次导致活性加氢胺化催化剂。

  DOI：

  10.1002/ejoc.201200891

文献信息

• Uncatalysed intermolecular aza-Michael reactions
  作者：Florian Medina、Nathalie Duhal、Christophe Michon、Francine Agbossou-Niedercorn

  DOI：10.1016/j.crci.2012.11.001

  日期：2013.4

  Résumé The catalyst-free reactions of activated alkenes with primary and secondary amines were investigated leading to various mono- and di-hydroamination products, the latter being rare and original. These reactions were shown to depend first on the strength of the nucleophile. Temperature and steric hindrance of the reagents were the other key factors controlling the selectivity of these aza-Michael reactions. In spite of their poor nucleophilicities, some N-heterocyclic amines could react with different activated alkenes affording valuable intermediates. Such results tended to demonstrate the hydrogen-bonding interactions between activated alkenes and poly-nitrogen aromatic cycles may control these concerted or fully conjugate aza-Michael additions. Supplementary Materials: Supplementary material for this article is supplied as a separate file: mmc1.doc

  简历 摘要 研究了活性烯烃与一级和二级胺的无催化剂反应，生成多种单氢胺化和双氢胺化产物，后者较为罕见且具有原创性。这些反应首先取决于亲核试剂的强度。温度和试剂的立体阻碍是控制这些氮杂迈克尔反应选择性的其他关键因素。尽管某些含氮杂环胺的亲核性较差，但它们仍能与不同的活性烯烃反应，生成有价值的中间体。这些结果倾向于表明，活性烯烃与多氮芳香环之间的氢键相互作用可能控制这些协同或完全共轭的氮杂迈克尔加成反应。 补充材料： 本文的补充材料以单独文件提供： mmc1.doc
• Waste corn-cob cellulose supported bio-heterogeneous copper nanoparticles for aza-Michael reactions
  作者：Shaheen M. Sarkar、T. Sultana、Tapan Kumar Biswas、Md. Lutfor Rahman、Mashitah Mohd Yusoff

  DOI：10.1039/c5nj02437d

  日期：——

  Waste corn-cob cellulose supported Cu-nanoparticles were found to be a highly effective catalyst for aza-Michael reactions at room temperature.

  废弃的玉米芯纤维支持的铜纳米颗粒被发现是一种在室温下高效的氮杂Michael反应催化剂。
• Tapioca Cellulose Based Copper Nanoparticles for Chemoselective <i>N</i>-Alkylation
  作者：Md. Shaharul Islam、Bablu Hira Mandal、Tapan Kumar Biswas、Md. Lutfor Rahman、S. S Rashid、Suat-Hian Tan、Shaheen M Sarkar

  DOI：10.1166/jnn.2017.12930

  日期：2017.1.1

  Biomaterials as a support for catalysts are of prime importance. Tapioca root which is an abundant biopolymer source was used to synthesize cellulose supported bio-heterogeneous poly(hydroxamic acid) copper nanoparticles (CuN@PHA) and was characterized by Fourier transform infrared spectroscopy (FTIR), ultraviolet–visible spectroscopy (UV-Vis), field emission scanning electron microscopy (FESEM), X-ray photoelectron spectroscopy (XPS), inductively coupled plasma atomic emission spectroscopy (ICP-AES), transmission electron microscopy (TEM) analyses. The tapioca cellulose supported CuN@PHA (50 mol ppm) effectively catalyzed N-alkylation reaction of aliphatic amines with α,β-unsaturated compounds to give the corresponding alkylated products. High yields up to 95% were achieved for the converted products. The reusability of the cellulose supported nanoparticles was found to be excellent with no significant reduction of its catalytic activity over several cycles. The catalyst showed high catalytic activity having turnover number (TON) 18000 and turnover frequency (TOF) 2250 h−1.

  作为催化剂载体的生物材料至关重要。淀粉作为丰富的生物聚合物来源，被用于合成纤维素负载的生物非均相聚羟肟酸铜纳米颗粒（CuN@PHA），并采用傅里叶变换红外光谱（FTIR）、紫外-可见光谱（UV-Vis）、场发射扫描电子显微镜（FESEM）、X射线光电子光谱（XPS）、电感耦合等离子体原子发射光谱（ICP-AES）、透射电子显微镜（TEM）等手段进行了表征。淀粉纤维素负载的CuN@PHA（50 mol ppm）有效地催化脂肪胺与α,β-不饱和化合物的N-烷基化反应，得到相应的烷基化产物。转化产物的产率高达95%。纤维素负载的纳米颗粒具有优异的重复使用性，在多次循环中其催化活性没有显著降低。该催化剂显示出高催化活性，其转化数（TON）为18000，转化频率（TOF）为2250 h−1。
• Bio-heterogeneous Cu(0)NC@PHA for n-aryl/alkylation at room temperature
  作者：Choong Jian Fui、Tang Xin Ting、Mohd Sani Sarjadi、Shaheen M. Sarkar、Baba Musta、Md Lutfor Rahman

  DOI：10.1016/j.poly.2021.115310

  日期：2021.9
• Polymer, resist protective coating material, and patterning process
  申请人：Harada Yuji

  公开号：US20080085466A1

  公开（公告）日：2008-04-10

  A resist protective coating material comprises a polymer comprising repeat units having formulae (1 a ) and (1 b ) and having a Mw of 1,000-500,000. R 1a and R 1b are H, F or alkyl or fluoroalkyl, R 2a , R 2b , R 3a and R 3b are H or alkyl, or R 2a and R 2b , and R 3a and R 3b may bond together to form a ring, 0