4-(4-nitrophenyl)-N-phenyl-1,3-oxazol-2-amine | 1387566-47-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(4-nitrophenyl)-N-phenyl-1,3-oxazol-2-amine
• CAS: 1387566-47-3
• 化学式: C₁₅H₁₁N₃O₃
• 分子量: 281.271
• InChiKey: VYJJPFYZTBOWGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  苯基脲 、 2-溴-4'-硝基苯乙酮 反应 0.2h， 以90%的产率得到4-(4-nitrophenyl)-N-phenyl-1,3-oxazol-2-amine
  参考文献：
  名称：

  Ultrasound and deep eutectic solvent (DES): A novel blend of techniques for rapid and energy efficient synthesis of oxazoles

  摘要：

  The present work deals with the synthesis of novel oxazole compounds by using effective combination of ultrasound (US) and deep eutectic solvent (DES). The reaction was also conducted by thermal method (NUS) and the comparative studies are provided. It was observed that applying ultrasound not only improved yields and reduced reaction times but also saved more than 85% energy as shown by energy consumption calculations. The advantages of using DES as reaction medium is highlighted from the fact that it is bio-degradable, non-toxic, recyclable and could be easily prepared using inexpensive raw materials. The recyclability for DES was studied wherein it was found that ultrasound has no negative effects on DES even up to four runs. In addition, the present work is the first report on the combinative use of DES and US in organic synthesis. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ultsonch.2012.06.003