4-(1-(2-methoxyphenyl)-3-phenylprop-2-yn-1-yl)morpholine | 1174758-86-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 4-(1-(2-methoxyphenyl)-3-phenylprop-2-yn-1-yl)morpholine
• 英文别名: 4-[1-(2-Methoxyphenyl)-3-phenylprop-2-ynyl]morpholine；4-[1-(2-methoxyphenyl)-3-phenylprop-2-ynyl]morpholine
• CAS: 1174758-86-1
• 化学式: C₂₀H₂₁NO₂
• 分子量: 307.392
• InChiKey: DFTWEYATJHLVHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(1-(2-methoxyphenyl)-3-phenylprop-2-yn-1-yl)morpholine 、 N-氟代双苯磺酰胺 在 indium(III) triflate 、 sodium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以80%的产率得到N-(3-(2-methoxyphenyl)-1-phenylpropa-1,2-dien-1-yl)-N-(phenylsulfonyl)benzenesulfonamide
  参考文献：
  名称：

  Divergent Synthesis of Allenylsulfonamide and Enaminonesulfonamide via In(III)-Catalyzed Couplings of Propargylamine and N-Fluorobenzenesulfonimide

  摘要：

  An In(III)-catalyzed facile and controllable method for the synthesis of allenylsulfonamide and enaminonesulfonamide has been achieved by the reaction between propargylamine and N-fluorobenzenesulfonimide (NFSI) under mild conditions. The present protocol is also applicable to the synthesis of tetrasubstituted allenylsulfonamide from triphenyl propargylalcohol. Experimental results suggest that the reaction probably proceeds through the ionic pathway.

  DOI：

  10.1021/acs.joc.8b01882
• 作为产物：
  描述：

  吗啉 、 苯乙炔 、 邻甲氧基苯甲醛 在 copper terephthalate metal-organic framework enriched on microscale Cu(II)-based carboxymethylcellulose composite fibers (4.5 mol% of Cu ) 作用下， 以 甲苯 为溶剂， 以93 %的产率得到4-(1-(2-methoxyphenyl)-3-phenylprop-2-yn-1-yl)morpholine
  参考文献：
  名称：

  Cu(BDC) 在微型 Cu 基羧甲基纤维素纤维上的原位生长：构建 A3 偶联反应高效催化剂的新策略

  摘要：

  基于羧甲基纤维素 (CMC) 中的羧酸盐与金属离子的配位特性，我们通过将 CMC-Na 溶液挤出到 Cu(II) 离子凝固浴中制备了微型铜基羧甲基纤维素纤维 (Cu(II)/CMC)。我们发现，所获得的微型 Cu(II)/CMC 纤维非常适合直接从纤维表面富集的配位 Cu(II) 位点原位生长对苯二甲酸铜 (Cu(BDC)) MOFs（ Cu(BDC)@Cu(II)/CMC)在对苯二甲酸溶液中。使用各种 FTIR、XRD、SEM、EDX、元素映射、XPS、TGA 和 BET 工具验证了 Cu(BDC)@Cu(II)/CMC 复合纤维的组成和结构。表征数据表明，明确定义的 Cu(BDC) 颗粒均匀分布在微米级 Cu 基纤维的表面。3）偶联反应。优异的催化活性归因于微型纤维上含有大量活性 Cu(II) 位点的 Cu(BDC) MOFs 微晶的优异分散性和稳定性。此外，微型纤维催化剂可以在每次循

  DOI：

  10.1002/aoc.7041

文献信息

• A Simple and Economic Synthesis of Propargylamines by CuI-Catalyzed Three-Component Coupling Reaction with Succinic Acid as Additive
  作者：Gerui Ren、Jinli Zhang、Zheng Duan、Mengjun Cui、Yangjie Wu

  DOI：10.1071/ch08086

  日期：——

  A practical and efficient method was developed for the synthesis of propargylamines in a one-pot procedure from aldehydes, amines, and alkynes by using CuI as catalyst and succinic acid as additive. By using this protocol, a wide range of propargylamines was obtained in high yields.

  开发了一种实用有效的方法，以CuI为催化剂，以琥珀酸为添加剂，通过一锅法从醛，胺和炔烃合成炔丙基胺。通过使用此协议，可以高收率获得各种炔丙基胺。
• Synthesis and characterization of magnetic glycocyamine-modified chitosan as a biosupport for the copper immobilization and its catalytic activity investigation
  作者：F. Rafiee、F. Rezaie Karder

  DOI：10.1016/j.reactfunctpolym.2019.104434

  日期：2020.1

  coordination. The magnetization of modified chitosan was done using of Fe3O4 nanoparticles. In the presence of coordinated groups of glycocyamine containing amidino and carboxylate, copper ions were immobilized on this magnetic biopolymer. This new nanocomposite (Fe3O4@CSC@AG@Cu) was characterized by FT-IR, FE-SEM, EDX, XRD, VSM, DRS and ICP analysis. After which, its catalytic activity was examined in the three

  摘要Trichloro-1,3,5-triazine试剂用于壳聚糖功能化，并作为功能化壳聚糖和糖胺之间的桥梁，形成铜配位的生物配体。改性壳聚糖的磁化是使用Fe3O4纳米粒子完成的。在含有glyco基和羧酸根的糖胺的配位基团的存在下，铜离子被固定在该磁性生物聚合物上。通过FT-IR，FE-SEM，EDX，XRD，VSM，DRS和ICP分析对这种新型纳米复合材料（Fe3O4 @ CSC @ AG @ Cu）进行了表征。此后，在脂族和芳族醛，仲环胺和苯基乙炔的三个偶联反应中，对炔丙基胺衍生物的合成进行了催化活性研究。
• One-pot three-component synthesis of propargylamines using an efficient and reusable copper bio-functionalized magnetic graphene oxide nanocomposite
  作者：Fatemeh Rafiee、Parvaneh Khavari

  DOI：10.1016/j.poly.2019.114309

  日期：2020.2

  In this work, magnetic graphene oxide was produced through chemical oxidation of the graphite powder, exfoliation under ultrasonic waves and then magnetization in the presence of ion salts. Magnetic graphene oxide was functionalized with cysteine and used as efficient support for the immobilization and suitable dispersing of copper ions. This nanocatalyst was characterized using FT-IR, TEM, EDX, XRD, VSM, XPS and ICP-OES analysis. Very low loading of prepared nanocomposite was showed high activity in the synthesis of propargylamine derivatives via A(3)-coupling reaction. It simply recovered from the reaction mixture by using an external magnetic field and reused without any pre-activation in next tests with acceptable yields. (C) 2019 Elsevier Ltd. All rights reserved.
• Divergent Synthesis of Allenylsulfonamide and Enaminonesulfonamide via In(III)-Catalyzed Couplings of Propargylamine and <i>N</i>-Fluorobenzenesulfonimide
  作者：Sadhanendu Samanta、Alakananda Hajra

  DOI：10.1021/acs.joc.8b01882

  日期：2018.11.2

  An In(III)-catalyzed facile and controllable method for the synthesis of allenylsulfonamide and enaminonesulfonamide has been achieved by the reaction between propargylamine and N-fluorobenzenesulfonimide (NFSI) under mild conditions. The present protocol is also applicable to the synthesis of tetrasubstituted allenylsulfonamide from triphenyl propargylalcohol. Experimental results suggest that the reaction probably proceeds through the ionic pathway.