1--2,3-epoxypropane | 88737-42-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1--2,3-epoxypropane
• 英文别名: 2-{[4-(Cyclopent-2-en-1-yl)phenoxy]methyl}oxirane；2-[(4-cyclopent-2-en-1-ylphenoxy)methyl]oxirane
• CAS: 88737-42-2
• 化学式: C₁₄H₁₆O₂
• 分子量: 216.28
• InChiKey: HBHPDJDGJOPMHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  21.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5,5-二甲基海因 、 1--2,3-epoxypropane 在 吡啶 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以0.38 g的产率得到3-[3'-(4"-cyclopent-2'''-en-1'''-ylphenoxy)-2'-hydroxypropyl]-5,5-dimethylimidazolidine-2,4-dione
  参考文献：
  名称：

  Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase

  摘要：

  The synthesis and inhibitory potencies of a novel series of beta-amino alcohols, based on the hit-compound 3-[3`-(4 ''-cyclopent-2```-en-1```-ylphenoxy)-2`-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.099
• 作为产物：
  描述：

  环戊二烯 在 磷酸 、 potassium carbonate 作用下， 以 水 、 丙酮 、 甲苯 为溶剂， 反应 18.0h， 生成 1--2,3-epoxypropane
  参考文献：
  名称：

  Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase

  摘要：

  The synthesis and inhibitory potencies of a novel series of beta-amino alcohols, based on the hit-compound 3-[3`-(4 ''-cyclopent-2```-en-1```-ylphenoxy)-2`-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.099

文献信息

• Kumar, Surat; Rastogi, Shri Nivas, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1983, vol. 22, # 7, p. 659 - 663
  作者：Kumar, Surat、Rastogi, Shri Nivas

  DOI：——

  日期：——
• KUMAR, SURAT;RASTOGI, SRI, NIVAS, INDIAN J. CHEM., 1983, 22, N 7, 59-663
  作者：KUMAR, SURAT、RASTOGI, SRI, NIVAS

  DOI：——

  日期：——
• Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase
  作者：Elizabeth Fullam、Areej Abuhammad、David L. Wilson、Matthew C. Anderton、Steve G. Davies、Angela J. Russell、Edith Sim

  DOI：10.1016/j.bmcl.2010.12.099

  日期：2011.2

  The synthesis and inhibitory potencies of a novel series of beta-amino alcohols, based on the hit-compound 3-[3`-(4 ''-cyclopent-2```-en-1```-ylphenoxy)-2`-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined. (c) 2010 Elsevier Ltd. All rights reserved.