(R)-3-hydroxyoctanal | 934986-26-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-3-hydroxyoctanal
• 英文别名: (3R)-3-hydroxyoctanal
• CAS: 934986-26-2
• 化学式: C₈H₁₆O₂
• 分子量: 144.214
• InChiKey: ZFLQRMNQASYFSB-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-3-hydroxyoctanal 在 4-甲基苯磺酸吡啶 、 四氯化锡 作用下， 以 二氯甲烷 为溶剂， 生成 (4S,6R)-4-allyl-2,2-dimethyl-6-pentyl-1,3-dioxane
  参考文献：
  名称：

  A Short and Highly Diastereoselective Synthesis of Verbalactone

  摘要：

  利用高度非对映和对映选择性的烯丙基金属化反应以及 Yamaguchi 大内酯化反应，通过七个步骤从市售己醛中合成了马鞭草内酯，并获得了良好的收率。

  DOI：

  10.1055/s-2007-967946
• 作为产物：
  描述：

  (R)-1-((R)-4-benzyl-2-thioxo-thiazolidin-3-yl)-3-hydroxyoctan-1-one 在 二异丁基氢化铝 、 Rochelle's salt 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 0.08h， 生成 (R)-3-hydroxyoctanal
  参考文献：
  名称：

  Stereoselective synthesis towards verbalactone and (+)-(3R,5R)-3-hydroxy-5-decanolide

  摘要：

  The stereoselective synthesis towards biologically active verbalactone and (+)-(3R,5R)-3-hydroxy-5-decanolide has been described. The key functionalities are derived from a chiral-auxiliary mediated acetate aldol addition, an oxa-Michael reaction and a 1,3-syn-reduction. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2012.03.002

文献信息

• Particulate construct comprising polyhydroxyalkanoate and method for producing it
  申请人：——

  公开号：US20030194443A1

  公开（公告）日：2003-10-16

  The invention provides a particulate construct such as microcapsules containing a drug, and serving a slow releasing preparation not associated with a practically unacceptable initial burst release but showing a practically acceptable zero-order release for a certain period and a producing method for such particulate construct, and a slow releasing preparation of a high drug content capable of stably incorporating the drug in the particulate construct such as microcapsules, and a producing method for such preparation. The invention also provides a particulate construct such as microcapsules utilizing a highly functional polymer compound and incorporating oil phase and/or water phase in solid phase, and a producing method therefor. Furthermore, the invention provides a particulate construct such as microcapsules having a hollow structure of a single polymer membrane as the outer shell and capable of containing many bubbles in the fine particles, and a producing method capable of preparing such construct with a high reproducibility. According to the invention, a particulate construct such as microcapsules is formed with polyhydroxyalkanoate of a specified structure and a drug for a desired purpose, an oil phase and/or a water phase, or a gaseous phase is included in such construct.

  本发明提供了一种微粒构造物，例如包含药物的微胶囊，用作缓释制剂，不会出现实际上不可接受的初始爆发释放，但在一定时间内显示实际上可接受的零级释放，并提供了这种微粒构造物的制备方法，以及能够稳定地将药物纳入微粒构造物中，例如微胶囊的高药物含量的缓释制剂，以及这种制备方法。本发明还提供了一种利用高功能聚合物化合物并将油相和/或水相纳入固相的微粒构造物，以及其制备方法。此外，本发明还提供了一种具有单一聚合物膜的空心结构的微粒构造物，能够在细小的颗粒中包含许多气泡，并提供了一种能够高度重复制备这种构造物的制备方法。根据本发明，可使用具有特定结构的聚羟基烷酸酯和药物制备微粒构造物，该构造物中包含油相和/或水相或气态相。
• Coloring composition for color filters containing microencapsulated pigment composed of polyhydroxyalkanoate
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20030203458A1

  公开（公告）日：2003-10-30

  The invention provides coloring composition for color filters making use of a pigment, in which the dispersed state of the pigment is stable without using any surfactant, and so aggregation is hard to occur, and which permits formation of high-definition and high-quality images excellent in color rendition, transparency and contrast, and a simple production process thereof, by which the use of surfactants can be abolished, or the amount of surfactants used can be reduced to a great extent. The coloring composition for color filters is provided by using at least a coloring material obtained by coating at least part of surfaces of pigment particles with polyhydroxyalkanoate, and a dispersion medium for the coloring material.

  该发明提供了一种用于彩色滤光片的染色组合物，其中颜料的分散状态稳定，不需要使用任何表面活性剂，因此聚集很难发生，并且允许形成高清晰度和高质量的图像，具有出色的色彩再现度、透明度和对比度，以及简单的生产过程，通过该过程可以废除表面活性剂的使用，或者大大减少所使用的表面活性剂的数量。通过使用至少一种染色材料，该染色材料通过在颜料颗粒的至少一部分表面上涂覆聚羟基烷酸酯而获得，并且用于染色材料的分散介质。
• Pigment containing ink and production method thereof
  申请人：——

  公开号：US20030203987A1

  公开（公告）日：2003-10-30

  A micro-capsulated pigment containing pigment ink being excellent in density, fineness, transparency, and coloring and color rendering properties required for ink solutions and having excellent dispersibility and dispersion stability with time due to the reduced particle size is provided. At least a color material with at least part of the surfaces of pigment particles covered with polyhydroxyalkanoate, and a medium for dispersion of the color material are used to obtain the pigment ink.

  提供了一种微胶囊化颜料，其中包含颜料油墨，其具有油墨溶液所需的密度、细度、透明度、着色和色彩还原性，由于粒子尺寸的减小，具有优异的分散性和稳定性。使用至少一种颜料材料，其中颜料颗粒的至少一部分表面被聚羟基脂肪酸酯覆盖，以及用于分散颜料材料的介质来获得颜料油墨。
• Electrostatic charge image developing toner, producing method therefor, image forming method and image forming apparatus utilizing the toner, construct and method for making the construct
  申请人：Canon Kabushiki Kaisha

  公开号：US20040259026A1

  公开（公告）日：2004-12-23

  A construct that comprises a base material and a polyhydroxyalkanoate, wherein at least a part of the base material is coated with the polyhydroxyalkanoate, and the polyhydroxyalkanoate comprises a 3-hydroxyalkanoic acid unit other than 3-hydroxypropionic acid unit, 3-hydroxy-n-butyric acid unit, and 3-hydroxy-n-valeric acid unit. In addition, an electrostatic charge image developing toner allows to design the toner characteristics such as chargeability, flowability, stability in time and environmental stability uniform among the toners of different colors. The toner has a small particle size enough for enabling uniform dispersion and being excellent in color saturation and transparency. The toner also shows higher contribution to the environmental security. The toner includes a coloring agent of which at least a part of the surface is covered with polyhydroxyalkanoate (PHA). The toner is produced by dispersing the coloring agent in aqueous medium, then fixing PHA synthesizing enzyme to the coloring agent dispersed in the aqueous medium, then adding 3-hydroxyacyl CoA, and executing a PHA synthesizing reaction to cover at least a part of the surface of the coloring agent with PHA. The toner thus obtained is used for an image forming method.

  一种构造物，包括基材料和聚羟基脂肪酸酯，其中至少一部分基材料被聚羟基脂肪酸酯涂覆，而聚羟基脂肪酸酯包括除了3-羟基丙酸单元、3-羟基-n-丁酸单元和3-羟基-n-戊酸单元之外的3-羟基脂肪酸单元。 此外，静电荷图像开发调色剂可以使调色剂的特性如电荷性、流动性、时间稳定性和环境稳定性在不同颜色的调色剂之间保持一致。调色剂具有足够小的粒径，足以实现均匀分散，并具有优异的色彩饱和度和透明度。调色剂还显示出更高的环境安全贡献。调色剂包括至少部分表面覆盖聚羟基脂肪酸酯（PHA）的着色剂。调色剂通过将着色剂分散在水性介质中，然后将PHA合成酶固定在分散在水性介质中的着色剂上，然后添加3-羟基酰基辅酶A，并执行PHA合成反应，以覆盖至少着色剂表面的一部分与PHA。因此获得的调色剂用于图像形成方法。
• Particles for electrophoresis, a production method thereof and a display using the articles
  申请人：——

  公开号：US20030206330A1

  公开（公告）日：2003-11-06

  Electrophoretic particles for electrophoretic display having excellent dispersibility and dispersion stability with time for insulating media, and being protected against coagulation, settling and the like, a process for production of the electrophoretic particles having high versatility for pigments to be used in response to a full-color display, and an electrophoretic display device using the electrophoretic particles that has an excellent memory property and is highly reliable are provided. The electrophoretic particles are formed using as at least a part of structure a pigment with at least a part of the surface covered with polyhydroxyalkanoate.

  提供了一种具有优异分散性和分散稳定性的电泳显示用电泳粒子，适用于绝缘介质，并受到凝聚、沉淀等的保护。提供了一种用于生产具有高适用性的颜料的电泳粒子的过程，以响应全彩色显示，以及使用电泳粒子的电泳显示装置，具有优异的记忆性能和高可靠性。电泳粒子是使用至少部分表面覆盖聚羟基脂肪酸酯的颜料作为结构的一部分形成的。