Limaprost alfadex | 100459-01-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Limaprost alfadex
• 英文别名: (1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxaheptacyclo[26.2.2.23,6.28,11.213,16.218,21.223,26]dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol;(Z)-6-[(1R,2R,3R)-3-hydroxy-2-[(E,3S,5S)-3-hydroxy-5-methylnon-1-enyl]-5-oxocyclopentyl]hex-2-enoic acid
• CAS: 100459-01-6；88852-12-4
• 化学式: C57H94O35
• 分子量: 1339.3
• InChiKey: AURWGUVCKQSRJX-UYCJUBBXSA-N

物化性质

• 熔点：
  97-100 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -9.56
• 重原子数：
  92
• 可旋转键数：
  18
• 环数：
  23.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  570
• 氢给体数：
  21
• 氢受体数：
  35

文献信息

• Blood flow promoters for cauda equina tissues
  申请人：Ohmoto Kazuyuki

  公开号：US20070129327A1

  公开（公告）日：2007-06-07

  It is intended to provide highly safe and efficacious blood flow promoters for cauda equina tissues. Among prostaglandin-like compounds having a weak hypotensive effect, compounds having an effect of promoting the blood flow in cauda equina tissues (excluding limaprost) are useful as highly safe blood flow promoters for cauda equina tissues and, therefore, are efficacious in preventing and/or treating lumbar pain, lower limb pain, lower limb palsy, intermittent claudication, vesicorectal failure, hypogonadism, etc. caused by cauda equina injuries.

  旨在为马尾神经组织提供高度安全和有效的血流促进剂。在具有弱降压作用的前列腺素类似化合物中，具有促进马尾神经组织血流的作用的化合物（不包括利马前列素）作为高度安全的马尾神经组织血流促进剂是有用的，并且在预防和/或治疗由马尾神经损伤引起的腰痛、下肢疼痛、下肢麻痹、间歇性跛行、膀胱直肠功能障碍、性腺功能减退等方面具有疗效。
• US7833995B2
  申请人：——

  公开号：US7833995B2

  公开（公告）日：2010-11-16