3-[4-(2-Methyl-1,3-oxazol)-yl]-pyridine | 122829-67-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[4-(2-Methyl-1,3-oxazol)-yl]-pyridine
• 英文别名: 2-Methyl-4-(pyridin-3-yl)oxazole；2-methyl-4-pyridin-3-yl-1,3-oxazole
• CAS: 122829-67-8
• 化学式: C₉H₈N₂O
• 分子量: 160.175
• InChiKey: KKKGWSFASJUVJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  38.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] COUMARIN-MODIFIED ANDROGENS FOR THE TREATMENT OF PROSTATE CANCER<br/>[FR] ANDROGÈNES À COUMARINE MODIFIÉE POUR LE TRAITEMENT DU CANCER DE LA PROSTATE
  申请人：HEALTH RESEARCH INC

  公开号：WO2020223174A1

  公开（公告）日：2020-11-05

  Provided are androstane and dihydrotestosterone compounds functionalized with carbocyclic groups or heterocyclic groups that may be saturated or unsaturated. The compounds may be used in methods of inhibiting cell growth of malignant cells and/or hyperplastic cells and/or treating individuals having diseases associated with malignant cell growth (e.g., cancer, such as, for example, prostate cancer) and/or hyperplastic cell growth and/or molecular imaging of malignant cells and/or hyperplastic cells and/or inducing degradation of a target protein. Also provided are compositions.

  提供的是功能化为碳环族或杂环族的雄烷和二氢睾酮化合物，这些化合物可能是饱和的或不饱和的。这些化合物可以用于抑制恶性细胞和/或增生细胞的细胞生长的方法，治疗患有与恶性细胞生长相关的疾病的个体（例如，癌症，例如前列腺癌）和/或增生细胞生长和/或恶性细胞和/或增生细胞的分子成像和/或诱导目标蛋白的降解。还提供了组合物。
• Oxazoles and thiazoles for the treatment of senile dementia
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP0307141B1

  公开（公告）日：1993-01-13
• COUMARIN-MODIFIED ANDROGENS FOR THE TREATMENT OF PROSTATE CANCER
  申请人：Health Research, Inc.

  公开号：US20220218722A1

  公开（公告）日：2022-07-14

  Provided are androstane and dihydrotestosterone compounds functionalized with carbocyclic groups or heterocyclic groups that may be saturated or unsaturated. The compounds may be used in methods of inhibiting cell growth of malignant cells and/or hyperplastic cells and/or treating individuals having diseases associated with malignant cell growth (e.g., cancer, such as, for example, prostate cancer) and/or hyperplastic cell growth and/or molecular imaging of malignant cells and/or hyperplastic cells and/or inducing degradation of a target protein. Also provided are compositions.
• US5324723A
  申请人：——

  公开号：US5324723A

  公开（公告）日：1994-06-28
• US7332476B2
  申请人：——

  公开号：US7332476B2

  公开（公告）日：2008-02-19