4-(2,5-Dioxo-3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid | 33753-36-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2,5-Dioxo-3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid
• 英文别名: 4-(2,5-dioxo-3-phenylpyrrol-1-yl)benzoic acid
• CAS: 33753-36-5
• 化学式: C₁₇H₁₁NO₄
• 分子量: 293.279
• InChiKey: QEDHREXPGJIOAU-UHFFFAOYSA-N

物化性质

• 沸点：
  536.4±50.0 °C(Predicted)
• 密度：
  1.430±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(2,5-Dioxo-3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid 在 吡啶 、 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 N,N'-1,4-phenylenebis[4-(2,5-dihydro-3-phenyl-2,5-dioxo-1H-pyrrol-1-yl)]benzamide
  参考文献：
  名称：

  The synthesis and characterisation of reactive poly(p-phenylene terephthalamide)s: A route towards compression stable aramid fibres

  摘要：

  Herein we report on the synthesis of reactive poly(p-phenylene terephthalamide) (PPTA) oligomers and the preparation and characterisation of aramid fibres thereof. Methacrylate and maleimide reactive end-groups were found to be sufficiently stable in H2SO4 at 85 degrees C and they were used to prepare reactive PPTA oligomers. Lyotropic spin-dopes could be prepared with up to 20 wt% of reactive oligomer (M-n = 3900 g mol(-1)) and this modification did not interfere with the fibre spinning process and had no effect on the fibre tensile properties. The as-spun fibres did indeed show a modest (+0.1 GPa) improvement in compression strength. A high temperature treatment at 380 degrees C resulted in fibres which all show a significant increase in compressive strength over their as-spun precursors, i.e. from 0.7 to 0.9 GPa. When fibres were treated at 430 degrees C the compression values of the oligomer-modified fibres dropped somewhat, whereas unmodified PPTA displayed a compressive strength of 1.1 GPa. Other favourable fibre properties such as modulus and tenacity were not compromised. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2010.03.015
• 作为产物：
  描述：

  苯基顺酐 、 对氨基苯甲酸 在 溶剂黄146 作用下， 反应 3.0h， 以93%的产率得到4-(2,5-Dioxo-3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid
  参考文献：
  名称：

  调节WNT信号通路的酰胺类化合物及其用途

  摘要：

  本发明属于医药技术领域，特别涉及调节WNT信号通路的酰胺类化合物及其用途。根据本发明的化合物具有通式I所示的结构：

  公开号：

  CN109867661B

文献信息

• US7507784B2
  申请人：——

  公开号：US7507784B2

  公开（公告）日：2009-03-24
• 调节WNT信号通路的酰胺类化合物及其用途
  申请人：中国医学科学院药物研究所

  公开号：CN109867661B

  公开（公告）日：2022-07-19

  本发明属于医药技术领域，特别涉及调节WNT信号通路的酰胺类化合物及其用途。根据本发明的化合物具有通式I所示的结构：
• The synthesis and characterisation of reactive poly(p-phenylene terephthalamide)s: A route towards compression stable aramid fibres
  作者：Alwin Knijnenberg、Johan Bos、Theo J. Dingemans

  DOI：10.1016/j.polymer.2010.03.015

  日期：2010.4

  Herein we report on the synthesis of reactive poly(p-phenylene terephthalamide) (PPTA) oligomers and the preparation and characterisation of aramid fibres thereof. Methacrylate and maleimide reactive end-groups were found to be sufficiently stable in H2SO4 at 85 degrees C and they were used to prepare reactive PPTA oligomers. Lyotropic spin-dopes could be prepared with up to 20 wt% of reactive oligomer (M-n = 3900 g mol(-1)) and this modification did not interfere with the fibre spinning process and had no effect on the fibre tensile properties. The as-spun fibres did indeed show a modest (+0.1 GPa) improvement in compression strength. A high temperature treatment at 380 degrees C resulted in fibres which all show a significant increase in compressive strength over their as-spun precursors, i.e. from 0.7 to 0.9 GPa. When fibres were treated at 430 degrees C the compression values of the oligomer-modified fibres dropped somewhat, whereas unmodified PPTA displayed a compressive strength of 1.1 GPa. Other favourable fibre properties such as modulus and tenacity were not compromised. (C) 2010 Elsevier Ltd. All rights reserved.