4-ethoxy-1'H-[1,3'-bipyrrole]-3,4'-dicarbonitrile | 1354575-11-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-ethoxy-1'H-[1,3'-bipyrrole]-3,4'-dicarbonitrile
• 英文别名: 1-(4-cyano-1H-pyrrol-3-yl)-4-ethoxypyrrole-3-carbonitrile
• CAS: 1354575-11-3
• 化学式: C₁₂H₁₀N₄O
• 分子量: 226.238
• InChiKey: GCMVTPHSAFQHSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  77.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对甲基苯磺酰甲基异腈 、 2-氰基-3-乙氧基丙烯酸乙酯 在 sodium hydride 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以53%的产率得到4-ethoxy-1'H-[1,3'-bipyrrole]-3,4'-dicarbonitrile
  参考文献：
  名称：

  One-pot cascade approach to 1,3′-bipyrrole derivatives from trisubstituted olefins with tosylmethyl-isocyanide (TosMIC)

  摘要：

  A novel and effective route for the synthesis of 1,3'-bipyrrole derivatives by multisubstituted olefins with TosMIC was developed. Moreover, the synthetic protocol was simple and the reaction conditions were mild. A possible mechanism was proposed. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.11.076

文献信息

• One-pot cascade approach to 1,3′-bipyrrole derivatives from trisubstituted olefins with tosylmethyl-isocyanide (TosMIC)
  作者：Fangli Qiu、Jianwei Wu、Yaohong Zhang、Miao Hu、Yongping Yu

  DOI：10.1016/j.tetlet.2011.11.076

  日期：2012.1

  A novel and effective route for the synthesis of 1,3'-bipyrrole derivatives by multisubstituted olefins with TosMIC was developed. Moreover, the synthetic protocol was simple and the reaction conditions were mild. A possible mechanism was proposed. (C) 2011 Elsevier Ltd. All rights reserved.