4-[4-(4-Methoxyphenyl)-1,2-oxazol-5-yl]phenol | 1271728-04-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-[4-(4-Methoxyphenyl)-1,2-oxazol-5-yl]phenol
• 英文别名: 4-[4-(4-methoxyphenyl)-1,2-oxazol-5-yl]phenol
• CAS: 1271728-04-1
• 化学式: C₁₆H₁₃NO₃
• 分子量: 267.284
• InChiKey: LTNVFSATGZPVQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  55.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(4-Benzyloxyphenyl)-2-(4-methoxyphenyl)ethan-1-one 在 palladium 10% on activated carbon 、 盐酸羟胺 、 氢气 、 sodium carbonate 、 溶剂黄146 作用下， 以 甲醇 、 乙酸乙酯 、 甲苯 为溶剂， 115.0~135.0 ℃ 、413.7 kPa 条件下， 反应 32.0h， 生成 4-[4-(4-Methoxyphenyl)-1,2-oxazol-5-yl]phenol
  参考文献：
  名称：

  Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor

  摘要：

  A series of KRIBB3 analogs were synthesized by modifying substituents at aryl moieties of KRIBB3 for examining structure-activity relationships, and their inhibitory activities on microtubule polymerization were evaluated. The presence of free phenolic hydrogens in aryl moieties of KRIBB3 analogs plays an important role in inhibition of microtubule polymerization. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.044

文献信息

• Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor
  作者：Sangku Lee、Jae Nyoung Kim、Hyeong Kyu Lee、Kab Seog Yoon、Ki Deok Shin、Byoung-Mog Kwon、Dong Cho Han

  DOI：10.1016/j.bmcl.2010.12.044

  日期：2011.2

  A series of KRIBB3 analogs were synthesized by modifying substituents at aryl moieties of KRIBB3 for examining structure-activity relationships, and their inhibitory activities on microtubule polymerization were evaluated. The presence of free phenolic hydrogens in aryl moieties of KRIBB3 analogs plays an important role in inhibition of microtubule polymerization. (C) 2010 Elsevier Ltd. All rights reserved.