neopinone

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: neopinone
• 英文别名: (7aR,12bS)-9-methoxy-3-methyl-1,2,4,6,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
• 化学式: C₁₈H₁₉NO₃
• 分子量: 297.354
• InChiKey: LJVKMVSYTWPNGA-MIIWOSQWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  neopinone 在 potassium dihydrogen phosphate 、 codeine: NADP oxidoreductase 作用下， 以 水 为溶剂， 反应 6.0h， 生成 codeine
  参考文献：
  名称：

  在非吗啡生物合成中将新松酮转化为可待因酮

  摘要：

  乙烯基醚裂解后的蒂巴因产生新松酮，其与可待因酮处于化学平衡状态。结果表明，在NADPH存在下，可待因：NADP氧化还原酶使这种平衡向可待因转移。

  DOI：

  10.1016/s0040-4039(00)73838-x
• 作为产物：
  描述：

  thebaine 在 mercury(II) diacetate 、 溶剂黄146 、 potassium bromide 作用下， 以 甲醇 为溶剂， 生成 neopinone
  参考文献：
  名称：

  Isoneopine from thebaine

  摘要：

  DOI：

  10.1021/jo00162a038

文献信息

• CONVERSION OF THEBAINE TO MORPHINE DERIVATIVES
  申请人：Carroll Robert James

  公开号：US20090005563A1

  公开（公告）日：2009-01-01

  The present invention provides methods for the conversion of thebaine to a morphine derivative, such as hydrocodone. Novel ketal intermediates of the conversion are provided. A one-pot procedure for the conversion comprises treating thebaine with an acid in the presence of a metal catalyst.

  本发明提供了将吗啡碱转化为吗啡衍生物（如羟考酮）的方法。提供了该转化的新型缩酮中间体。该转化的一锅法包括在金属催化剂存在下用酸处理吗啡碱。
• Papaver somniferum with high concentration of codeine
  申请人：Tasmanian Alkaloids Pty. Ltd.

  公开号：US10791691B2

  公开（公告）日：2020-10-06

  A poppy straw of Papaver somniferum, wherein the poppy straw includes codeine constituting about 40% by weight or greater of an alkaloid combination.

  罂粟的罂粟秆，其中罂粟秆包括可待因，占生物碱组合重量的 40% 或更多。
• Papaver somniferum strain with high concentration of thebaine
  申请人：Tasmanian Alkaloids Pty. Ltd.

  公开号：US10760090B2

  公开（公告）日：2020-09-01

  The present invention is directed to an improved poppy straw, concentrate of poppy straw and opium of Papaver somniferum for the production of thebaine containing little or no oripavine, codeine or morphine. The present invention also provides plants, stands and seeds of Papaver somniferum and methods for the production of thebaine.

  本发明涉及一种改良的罂粟秸秆、罂粟秸秆浓缩物和苏木鸦片，用于生产含少量或不含奥替巴因、可待因或吗啡的苏木碱。本发明还提供了罂粟的植物、支架和种子以及生产蒂巴因的方法。
• Salutaridinol 7-0-Acetyltransferase and Derivatives Thereof
  申请人：Kutchan Toni M.

  公开号：US20090053764A1

  公开（公告）日：2009-02-26

  This invention provides a protein comprising consecutive amino acids, the amino acid sequence of which is illustrated in FIG. 8 (SEQ. ID No. 14) or, a fragment thereof having at least 15 amino acids, or a variant thereof, the sequence of which has at least 70% identity with the amino acid sequence of FIG. 8 (SEQ. ID No. 14) over a length of at least 400 amino acids. This invention further provides a peptide comprising a fragment of salutaridinol 7-O-acetyltransferase protein of at least 6 consecutive amino acids which is not present in other plant acetyltransferases as illustrated in FIG. 2 (SEQ. IDs No. 8 to 12). This invention further provides a nucleic acid molecule comprising consecutive nucleotides (i) the nucleic acid sequence of which is illustrated in FIG. 9 (SEQ. ID No. 13) or FIG. 10 (SEQ. ID No. 15), or (ii) a fragment thereof having a length of at least 45 nucleotides, or (iii) a variant thereof, the sequence of which has at least 70% identity with the sequence of FIG. 9 (SEQ. ID No. 13) or FIG. 10 (SEQ. ID No. 15) over a length of at least 1200 bases, or a sequence complementary to (i), (ii) or (iii), or the RNA equivalent of any of (i), (ii), or (iii). This invention further provides a nucleic acid molecule comprising a fragment of a salutaridinol 7-O-acetyltransferase gene, at least 18 consecutive nucleotides unique to the salutaridinol 7-O-acetyltransferase gene and being chosen from the 5′ or 3′ untranslated regions of the sequence illustrated in FIG. 9 (SEQ. ID No. 13), or a sequence which is complementary thereto. This invention further provides a method for producing pentacyclic morphinan alkaloids comprising (i) introducing a nucleic acid molecule encoding salutaridinol 7-O-acetyltransferase into a plant cell capable of expressing salutaridinol and/or salutaridine and/or (R)-reticuline, (ii) propagating said plant cell to produce a multiplicity of morphinan-producing cells, and (iii) recovering said morphinan(s) from said multiplicity of cells. This invention further provides a method for the production of thebaine comprising the steps of (i) contacting in vitro a protein having salutaridinol 7-O-acetyltransferase activity with salutaridinol and acetyl co-enzyme A at pH 8 to 9, and (ii) recovering the thebaine thus produced.
• Papaver Somniferum Strain With High Concentration Of Thebaine
  申请人：Fist Anthony J.

  公开号：US20090227796A1

  公开（公告）日：2009-09-10

  The present invention is directed to an improved poppy straw, concentrate of poppy straw and opium of Papaver somniferum for the production of thebaine containing little or no oripavine, codeine or morphine. The present invention also provides plants, stands and seeds of Papaver somniferum and methods for the production of thebaine.