3-[[5-(4-Hydroxyphenyl)triazol-1-yl]methyl]phenol | 1350626-14-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[[5-(4-Hydroxyphenyl)triazol-1-yl]methyl]phenol
• 英文别名: 3-[[5-(4-hydroxyphenyl)triazol-1-yl]methyl]phenol
• CAS: 1350626-14-0
• 化学式: C₁₅H₁₃N₃O₂
• 分子量: 267.287
• InChiKey: BYWQVTOYJLUJCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  71.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(叠氮甲基)-3-甲氧基苯 在 二(三苯基膦)环戊二烯基氯化钌(II) 、 三溴化硼 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 14.0h， 生成 3-[[5-(4-Hydroxyphenyl)triazol-1-yl]methyl]phenol
  参考文献：
  名称：

  Designing 2-aminoimidazole alkaloids analogs with anti-biofilm activities: Structure–activities relationships of polysubstituted triazoles

  摘要：

  In order to discover novel probes that may help in the investigation and the control of bacterial biofilms, we have designed a library of triazole-based analogs of 2-aminoimidazole marine alkaloids: naamine A and isonaamine A. Twenty-two compounds were screened for their biofilm inhibitory activity against two strains of Gram-negative bacteria. Four compounds were shown to act as non-toxic inhibitors of biofilm development without effect on bacterial growth even at high concentrations (100 mu M). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.09.050

文献信息

• Designing 2-aminoimidazole alkaloids analogs with anti-biofilm activities: Structure–activities relationships of polysubstituted triazoles
  作者：D. Linares、O. Bottzeck、O. Pereira、A. Praud-Tabariès、Y. Blache

  DOI：10.1016/j.bmcl.2011.09.050

  日期：2011.11

  In order to discover novel probes that may help in the investigation and the control of bacterial biofilms, we have designed a library of triazole-based analogs of 2-aminoimidazole marine alkaloids: naamine A and isonaamine A. Twenty-two compounds were screened for their biofilm inhibitory activity against two strains of Gram-negative bacteria. Four compounds were shown to act as non-toxic inhibitors of biofilm development without effect on bacterial growth even at high concentrations (100 mu M). (C) 2011 Elsevier Ltd. All rights reserved.