2,5-anhydro-1-deoxy-D-talitol | 80924-00-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,5-anhydro-1-deoxy-D-talitol
• 英文别名: (2R,3R,4S,5R)-2-(hydroxymethyl)-5-methyloxolane-3,4-diol
• CAS: 80924-00-1
• 化学式: C₆H₁₂O₄
• 分子量: 148.159
• InChiKey: KPDBJZUAABGPIN-KAZBKCHUSA-N

物化性质

• 沸点：
  324.8±32.0 °C(Predicted)
• 密度：
  1.319±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-2-脱氧-D-半乳糖盐酸盐 在 镍 盐酸 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成 2,5-anhydro-1-deoxy-D-talitol
  参考文献：
  名称：

  2,5-anhydro-1-deoxy-d-lyxitol, 2,5-anhydro-1-deoxy-d-mannitol, and 2,5-anhydro-1-deoxy-d-talitol. Synthesis and enzymic studies

  摘要：

  DOI：

  10.1016/s0008-6215(00)80971-4

文献信息

• CARBOHYDRATE-GLYCOLIPID CONJUGATE VACCINES
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：US20150238597A1

  公开（公告）日：2015-08-27

  The present invention relates to the field of synthesizing and biologically evaluating of a novel class of carbohydrate-based vaccines. The new vaccines consist of a multi-modular structure which allows applying the vaccine to a whole variety of pathogenes. This method allows preparing vaccines against all pathogens expressing immunogenic carbohydrate antigens. As conjugation of antigenic carbohydrates to proteins is not required the conjugate vaccine is particularly heat stable. No refrigeration is required, a major drawback of protein-based vaccines.

  本发明涉及合成和生物评价一种新型基于碳水化合物的疫苗的领域。这种新疫苗由多模块结构组成，可以将疫苗应用于各种病原体。该方法允许制备针对所有表达免疫原碳水化合物抗原的病原体的疫苗。由于不需要将抗原碳水化合物与蛋白质结合，所以结合疫苗尤其耐热稳定。无需冷藏，这是基于蛋白质的疫苗的一个主要缺点。
• NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS
  申请人：MANOHARAN Muthiah

  公开号：US20120095075A1

  公开（公告）日：2012-04-19

  The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure:

  本发明提供了有利于用于体内向细胞传递治疗剂的脂质。具体而言，本发明提供具有以下结构的脂质：
• Lipids and compositions for the delivery of therapeutics
  申请人：Arbutus Biopharma Corporation

  公开号：US10835612B2

  公开（公告）日：2020-11-17

  The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures:

  本发明提供的脂质可用于脂质微粒中，有利于向细胞体内输送治疗剂。本发明尤其提供具有以下结构的脂质：
• LONG WAVELENGTH EMITTING CHEMILUMINESCENT PROBES
  申请人：NEMIS Technologies AG

  公开号：US20210214607A1

  公开（公告）日：2021-07-15

  Improved long wavelength-emitting chemiluminescent probes are easy to synthesize and are well-suited for both in vitro and in vivo applications, but are particularly well-suited for in vivo applications. The wavelengths of the emissions of the probes include those in the orange, red or NIR range. Dioxetane compounds and phenolic ester compounds are included.
• US9220683B2
  申请人：——

  公开号：US9220683B2

  公开（公告）日：2015-12-29