1-cyclohexyl-2-methylbutan-1-one | 17773-60-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-cyclohexyl-2-methylbutan-1-one
• 英文别名: sec-butyl cyclohexyl ketone；1-cyclohexyl-2-methyl-butan-1-one；1-Cyclohexyl-2-methyl-butan-1-on；Cyclohexyl-sec-butyl-keton
• CAS: 17773-60-3；61065-92-7
• 化学式: C₁₁H₂₀O
• 分子量: 168.279
• InChiKey: GGJPQFKWRUHDKT-UHFFFAOYSA-N

物化性质

• 沸点：
  224.7±8.0 °C(Predicted)
• 密度：
  0.897±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-Diazobutane 、 环己烷基甲醛 在 scandium tris(trifluoromethanesulfonate) 作用下， 以 甲苯 为溶剂， 反应 0.17h， 以78%的产率得到1-cyclohexyl-2-methylbutan-1-one
  参考文献：
  名称：

  通过催化碳插入甲酰基CH键中形成不同的烷酮。方便地获得天然的Achyrofuran

  摘要：

  一个多世纪前，重氮甲烷与醛的首次反应生成了甲基酮。在此期间，醛很少与三甲基甲硅烷基重氮甲烷，重氮乙酸酯和芳基重氮甲烷发生同系化反应。这项工作描述了一种由不稳定的重氮烷烃聚合酮组装的温和方法，包括使用双取代（内部）亲核试剂进行手性酮合成的实例。该方法对空间拥挤具有显着的耐受性，这是通过对复杂的二苯并呋喃呋喃呋喃进行的简单处理得到证实的。

  DOI：

  10.1021/ol9010932

文献信息

• Selective Homologation of Ketones and Aldehydes with Diazoalkanes Promoted by Organoaluminum Reagents
  作者：Keiji Maruoka、Amel B. Concepcion、Hisashi Yamamoto

  DOI：10.1055/s-1994-25682

  日期：——

  Organoaluminum-promoted single homologation or ring expansion of ketones and aldehydes with diazoalkanes has been described, and among various organoaluminum reagents, exceptionally bulky methylaluminum bis(2,6-di-tert-butyl-4-methylphenoxide) (MAD) is found to be highly effective for the selective homologation of various ketones and aldehydes.

  介绍了一种利用重氮烷烃进行的酮和醛的一级同系化或环扩张反应，并发现，在多种有机铝试剂中，特别庞大的甲基铝双(2,6-二叔丁基-4-甲基苯氧化物)(MAD)对各种酮和醛的选择性同系化具有高度效果。
• [EN] NEW COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS RELATING THERETO<br/>[FR] NOUVEAUX COMPOSÉS, COMPOSITION PHARMACEUTIQUE ET PROCÉDÉS CORRESPONDANTS
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2010149684A1

  公开（公告）日：2010-12-29

  New compounds are disclosed which have utility in the treatment of a variety of metabolic related conditions in a patient. The compounds of this invention have the structure (I): wherein R1, R2, R3, n, p, q, and Ar are as defined herein, including stereoisomers, solvates and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising a compound of this invention, as well as methods relating to the use thereof in a patient in need thereof.

  本发明公开了具有结构(I)的新化合物，其在患者中治疗各种与代谢相关的病症具有实用性：其中R1、R2、R3、n、p、q和Ar如本文所定义，包括立体异构体、溶剂合物和药学上可接受的盐。还公开了包含本发明化合物的药物组合物，以及关于其在有需要的患者中使用的方法。
• One-Pot Synthesis of Ketones Using<i>N</i>-Methoxy-<i>N</i>-Methyl-2-Pyridyl Urethane
  作者：Na Ra Lee、Jae In Lee

  DOI：10.1080/00397919908086099

  日期：1999.4

  Abstract The one-pot reaction of N-methoxy-N-methyl-2-pyridyl urethane with Grignard and organolithium reagents provided an efficient method for the preparation of unsymmetrical ketones.

  摘要 N-甲氧基-N-甲基-2-吡啶基氨基甲酸酯与格氏试剂和有机锂试剂的一锅反应为制备不对称酮提供了一种有效的方法。
• Enolization as Directed by Acid and Basic Catalysts. III. The Acid-Catalyzed Enolization of Some Secondary Butyl Ketones
  作者：Paul D. Bartlett、Charles H. Stauffer

  DOI：10.1021/ja01315a078

  日期：1935.12
• POLYAMIDE POLYMER, METHOD FOR PRODUCING SAME, RESIN COMPOSITION, MOLDED PRODUCT, FIBER, FILM, POROUS FILM
  申请人：Fujifilm Corporation

  公开号：US20130281563A1

  公开（公告）日：2013-10-24

  Provided is a polyamide polymer in which a partial structure represented by the following formula (C) constitutes a portion of the main chain: wherein in Formula (C), R A and R B each independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; n and m each independently represent an integer from 0 to 2; Cy represents an unsaturated 6-membered or 7-membered ring which may contain a heteroatom; and * and ** each represent a bonding hand, while * may be a bonding hand extending from R A .