N-(5-phenylmethoxy-2,3-dihydroindol-1-yl)benzamide | 344904-59-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(5-phenylmethoxy-2,3-dihydroindol-1-yl)benzamide
• CAS: 344904-59-2
• 化学式: C₂₂H₂₀N₂O₂
• 分子量: 344.413
• InChiKey: HABHDEKFGBQENN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(5-phenylmethoxy-2,3-dihydroindol-1-yl)benzamide 在 Ranei nickel 氢气 作用下， 以 乙醇 为溶剂， 以32%的产率得到N-(5-Hydroxy-2,3-dihydro-indol-1-yl)-benzamide
  参考文献：
  名称：

  N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase

  摘要：

  N-Aminoindoline derivatives were prepared and their 5-lipoxygenase inhibitory activities were evaluated in vitro and compared with those of phenidone and NDGA. Compound 4 presents the most effective 5-LO inhibition. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00077-4
• 作为产物：
  描述：

  5-苄氧基吲哚 在 盐酸 、 lithium aluminium tetrahydride 、 sodium cyanoborohydride 、 溶剂黄146 、 三乙胺 、 sodium nitrite 作用下， 以 乙醚 、 乙酸乙酯 为溶剂， 生成 N-(5-phenylmethoxy-2,3-dihydroindol-1-yl)benzamide
  参考文献：
  名称：

  N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase

  摘要：

  N-Aminoindoline derivatives were prepared and their 5-lipoxygenase inhibitory activities were evaluated in vitro and compared with those of phenidone and NDGA. Compound 4 presents the most effective 5-LO inhibition. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00077-4

文献信息

• N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase
  作者：Corinne Audouin、Nathalie Mestdagh、Marie-Agnès Lassoie、Raymond Houssin、Jean-Pierre Hénichart

  DOI：10.1016/s0960-894x(01)00077-4

  日期：2001.3

  N-Aminoindoline derivatives were prepared and their 5-lipoxygenase inhibitory activities were evaluated in vitro and compared with those of phenidone and NDGA. Compound 4 presents the most effective 5-LO inhibition. (C) 2001 Elsevier Science Ltd. All rights reserved.