6-(1-Azatricyclo[7.3.1.05,13]trideca-5,7,9(13)-trien-6-yloxy)-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13)-triene | 945225-36-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-(1-Azatricyclo[7.3.1.05,13]trideca-5,7,9(13)-trien-6-yloxy)-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13)-triene
• 英文别名: 6-(1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13)-trien-6-yloxy)-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13)-triene
• CAS: 945225-36-5
• 化学式: C₂₄H₂₈N₂O
• 分子量: 360.499
• InChiKey: WONDGTXGIZQTKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(1-Azatricyclo[7.3.1.05,13]trideca-5,7,9(13)-trien-6-yloxy)-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13)-triene 在 氢氧化钾 、 氧气 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 25.0h， 生成
  参考文献：
  名称：

  Synthesis and Characterization of a New Red-Emitting Ca²⁺ Indicator, Calcium Ruby

  摘要：

  Calcium Ruby m-Cl (X = H, Y = Cl) is a visible-light excited red-emitting calcium concentration ([Ca2+]) indicator dye (579/598 nm peak excitation/emission) with a side arm for conjugation via EDC or click chemistry. Its large molar extinction and high quantum yield rank it among the brightest long-wavelength Ca2+ indicators. Calcium Ruby is a promising alternative to existing dyes for imaging [Ca2+] in multicolor fluorescence applications or in the presence of yellow-green cellular autofluorescence.

  DOI：

  10.1021/ol070648h
• 作为产物：
  描述：

  3-(3-氨基苯氧基)苯胺 、 1-溴-3-氯丙烷 反应 36.0h， 以10%的产率得到6-(1-Azatricyclo[7.3.1.05,13]trideca-5,7,9(13)-trien-6-yloxy)-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13)-triene
  参考文献：
  名称：

  Synthesis and Characterization of a New Red-Emitting Ca²⁺ Indicator, Calcium Ruby

  摘要：

  Calcium Ruby m-Cl (X = H, Y = Cl) is a visible-light excited red-emitting calcium concentration ([Ca2+]) indicator dye (579/598 nm peak excitation/emission) with a side arm for conjugation via EDC or click chemistry. Its large molar extinction and high quantum yield rank it among the brightest long-wavelength Ca2+ indicators. Calcium Ruby is a promising alternative to existing dyes for imaging [Ca2+] in multicolor fluorescence applications or in the presence of yellow-green cellular autofluorescence.

  DOI：

  10.1021/ol070648h

文献信息

• Synthesis and Characterization of a New Red-Emitting Ca²⁺ Indicator, Calcium Ruby
  作者：Stéphane Gaillard、Aleksey Yakovlev、Camilla Luccardini、Martin Oheim、Anne Feltz、Jean-Maurice Mallet

  DOI：10.1021/ol070648h

  日期：2007.7.1

  Calcium Ruby m-Cl (X = H, Y = Cl) is a visible-light excited red-emitting calcium concentration ([Ca2+]) indicator dye (579/598 nm peak excitation/emission) with a side arm for conjugation via EDC or click chemistry. Its large molar extinction and high quantum yield rank it among the brightest long-wavelength Ca2+ indicators. Calcium Ruby is a promising alternative to existing dyes for imaging [Ca2+] in multicolor fluorescence applications or in the presence of yellow-green cellular autofluorescence.