2-(methoxymethyl)-1-phenylbutan-1-one | 67478-56-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(methoxymethyl)-1-phenylbutan-1-one
• CAS: 67478-56-2
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: DGVTWOCSBQFONU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-benzoylbutyl(trimethyl)azanium;iodide 生成 2-(methoxymethyl)-1-phenylbutan-1-one
  参考文献：
  名称：

  HOUSE H. O.; MCDANIEL W. C.; SIELOFF R. F.; VANDERVEER D., J. ORG. CHEM., 1978, 43, NO 22, 4316-4323

  摘要：

  DOI：

文献信息

• Visible-light-promoted α-methoxymethylation and aminomethylation of ketones with methanol as the C1 source
  作者：Jingya Yang、Cai Liu、Hongyan Zhou、Rundong Fan、Ben Ma、Zheng Li

  DOI：10.1039/d1ob00765c

  日期：——

  Visible-light-promoted α-methoxymethylation and aminomethylation of ketones using methanol as a sustainable C1 source have been developed. With rose bengal as the photosensitizer and air as the green oxidant, the methoxymethylation reactions proceeded smoothly under visible light irradiation at ambient temperature. Additionally, a one-pot one-step α-aminomethylation of ketones was achieved by adding

  已开发出使用甲醇作为可持续 C1 源的可见光促进的 α-甲氧基甲基化和酮的氨基甲基化。以玫瑰红为光敏剂，空气为绿色氧化剂，在常温可见光照射下，甲氧基甲基化反应顺利进行。此外，通过添加 N- 亲核试剂实现了酮的一锅一步 α-氨基甲基化。初步机理研究表明，该反应主要通过自由基途径进行。
• Magnetic MoS₂ efficient heterogeneous photocatalyst for the α-methoxymethylation and aminomethylation of aromatic ketones
  作者：Ya-Meng Wang、Wen-Jing Li、Miao-Miao Wang、Mo Zhang、Zhan-Hui Zhang

  DOI：10.1039/d2cy01831d

  日期：——

  Magnetic MoS₂ quantum dots are designed and applied as an efficient photocatalyst for the α-methoxymethylation and aminomethylation of aromatic ketones using methanol as a green C1 source in air under visible-light irradiation at room temperature.

  设计并应用磁性 MoS2 量子点作为高效光催化剂，使用甲醇作为绿色的 C1 源，在室温下在空气中可见光照射下，对芳香酮进行α-甲氧甲基化和氨基甲基化反应。
• Triazine Derivatives, a process for preparing the derivatives, and herbicides containing the derivatives as the effective component
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0191496A2

  公开（公告）日：1986-08-20

  A triazine derivative represented by the general formula: wherein R1 and R2 are each an alkyl group having 1 to 4 carbon atoms, and X1 and X2 are each a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxyl group having 1 to 4 carbon atoms, or an alkylthio group having 1 to 4 carbon atoms. This invention also provides a process for efficiently preparing said triazine derivative and a herbicide containing said triazine derivative as effective component.

  由通式代表的三嗪衍生物： 其中 R1 和 R2 分别为具有 1 至 4 个碳原子的烷基，X1 和 X2 分别为卤素原子、具有 1 至 4 个碳原子的烷基、具有 1 至 4 个碳原子的烷氧基或具有 1 至 4 个碳原子的烷硫基。 本发明还提供了一种高效制备所述三嗪衍生物和含有所述三嗪衍生物作为有效成分的除草剂的工艺。
• Cobalt-Catalyzed α-Methoxymethylation and Aminomethylation of Ketones with Methanol as a C1 Source
  作者：Jingya Yang、Shuwen Chen、Hongyan Zhou、Chengqi Wu、Ben Ma、Jianliang Xiao

  DOI：10.1021/acs.orglett.8b02892

  日期：2018.11.2

  Using methanol as a sustainable C1 source, cobalt-catalyzed alpha-methoxymethylation and alpha-aminomethylation of ketones have been developed. With cheap CoCl2 center dot 6H(2)O as catalyst and TBHP as oxidant, the methoxymethylated products were obtained within a short reaction time in up to 91% yield. Based on the observed reversibility of methoxy adduct to enone, the alpha-aminomethylation of ketones was then achieved by a one-pot methylenation/aza-Michael addition sequence. In addition, an easy way to convert alpha-methoxymethyl ketones to alpha-aminomethyl ketones has been discovered.
• US4680054A
  申请人：——

  公开号：US4680054A

  公开（公告）日：1987-07-14