7-bromomethyl-5,9-dihydro-6,8-dioxa-benzocycloheptene | 94267-82-0

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 7-bromomethyl-5,9-dihydro-6,8-dioxa-benzocycloheptene
• 英文别名: 5,6-benzo-2-(bromomethyl)-1,3-dioxepane；Bromacetaldehyd-；Bromacetaldehyd-(o-xylylenacetal)；3-(Bromomethyl)-1,5-dihydro-2,4-benzodioxepine
• CAS: 94267-82-0
• 化学式: C₁₀H₁₁BrO₂
• mdl: MFCD00297200
• 分子量: 243.1
• InChiKey: OWLOTYGUMKJPKR-UHFFFAOYSA-N

物化性质

• 沸点：
  330.4±37.0 °C(Predicted)
• 密度：
  1.427±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-bromomethyl-5,9-dihydro-6,8-dioxa-benzocycloheptene 在 甲基三辛基氯化铵 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以78%的产率得到5,6-benzo-2-methylene-1,3-dioxepane
  参考文献：
  名称：

  环烯酮缩醛的相转移催化新方法

  摘要：

  一个新的消除，其使用钾吨丁醇作为碱和季铵氯化物® 336作为相转移催化剂，已经开发了环状烯酮缩醛的合成。该方法具有低温，高收率，反应时间短等优点。

  DOI：

  10.1016/s0040-4039(00)74266-3
• 作为产物：
  描述：

  邻苯二甲酸二甲酯 在 lithium aluminium tetrahydride 、 对甲苯磺酸 作用下， 以 四氢呋喃 为溶剂， 反应 26.0h， 生成 7-bromomethyl-5,9-dihydro-6,8-dioxa-benzocycloheptene
  参考文献：
  名称：

  Synthesis and Characterization of Copolymers of 5,6-Benzo-2-methylene-1,3-dioxepane and Styrene

  摘要：

  Copolymerization behavior of 5,6-benzo-2-methylene-1,3-dioxepane (BMDO) with styrene (SO is studied using benzyl bromide/CuBr/1,1,4,7,7-pentamethyldiethylenetriamine radical initiating system. Structural characterization of copolymers was done using 1D and 2D NMR techniques. The copolymer compositions were obtained from H-1 NMR spectroscopy. The reactivity ratios for the copolymerization of BMDO with St were determined using Kelen-Tudos method and was found to be r(BMDO) 1.08 and r(St) = 8.53. Degradation behavior of the copolymers is also reported.

  DOI：

  10.1021/ma034551w

文献信息

• Biodegradable Glycopolymeric Micelles Obtained by RAFT-controlled Radical Ring-Opening Polymerization
  作者：Sylvia Ganda、Yanyan Jiang、Donald S. Thomas、Jeaniffer Eliezar、Martina H. Stenzel

  DOI：10.1021/acs.macromol.6b00266

  日期：2016.6.14

  further confirmed the appearance of fragmented glycopolymeric units. In vitro cell proliferation assay of the micelles and their degradation products revealed no toxicity against healthy human fibroblast HS27 and breast cancer MDA-MB-231 cell lines. The polymer concentration range tested was up to 0.20 mg·mL–1 with the cell viabilities of ≥95%.

  介绍了一种可完全降解的糖聚合物胶束的设计和合成。该设计依赖于利用RAFT控制的自由基开环聚合（rROP）技术将可裂解的酯键多次插入电晕的骨架上。使用基于聚（ε-己内酯）PCL的macroRAFT试剂进行RAFT聚合，以控制定义明确的统计糖聚合物的1- O-丙烯酰基-2,3：4,5-二-O-异亚丙基-β- d -fructopyranose（1- ø -A我PrFru）和5,6-苯并-2-亚甲基-1,3-二氧杂环庚烷（BMDO）单体。合成了三种嵌段共聚物以生成聚（ε-己内酯）-b-聚[（1- O-丙烯酰基-2,3：4,5-二-O-异亚丙基-β - d-果糖基吡喃糖）-co-（5,6-苯并-2-亚甲基-1,3-二氧戊环）]（PCL- b -P [（1- O -A i PrFru）-co-（BMDO）]），具有不同的块长度。自组装产生的非球形蛋形胶束去保护的嵌段共聚物所组成，其中更短的链PCL 106
• [EN] BIODEGRADABLE TREHALOSE GLYCOPOLYMERS<br/>[FR] GLYCOPOLYMÈRES BIODÉGRADABLES DE TRÉHALOSE
  申请人：UNIV CALIFORNIA

  公开号：WO2016025668A1

  公开（公告）日：2016-02-18

  Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5-[R1R2C - CR3R4]n-[DG]m-R6, wherein R1-R4 are independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R1-R4 is a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (-OH), wherein DG is a biodegradable group, and wherein R5 and R6 are end groups.

  生物可降解海藻糖共聚物的结构和制备方法被披露。具体来说，生物可降解海藻糖共聚物由一般结构R5-[R1R2C - CR3R4]n-[DG]m-R6组成，其中R1-R4独立地选自氢或包含至少一个碳原子的侧链，且R1-R4中至少有一个是包含-L-海藻糖的侧链，其中L是将海藻糖通过至少一个海藻糖羟基（-OH）连接到单体的连接分子，DG是一个生物可降解基团，R5和R6是末端基团。
• SUBSTITUTED POLYESTERS BY THIOL-ENE MODIFICATION: RAPID DIVERSIFICATION FOR THERAPEUTIC PROTEIN STABILIZATION
  申请人：The Regents of the University of California

  公开号：EP3342796A1

  公开（公告）日：2018-07-04

  Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5-[R1R2C - CR3R4]n-[DG]m-R6, wherein R1-R4 are independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R1-R4 is a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (-OH), wherein DG is a biodegradable group, and wherein R5 and R6 are end groups.

  本发明公开了可生物降解的三卤糖共聚物的结构和制造方法。具体来说，可生物降解的三卤糖共聚物由一般结构 R5-[R1R2C-CR3R4]n-[DG]m-R6组成，其中 R1-R4 独立地选自氢或包含至少一个碳原子的侧链、其中 R1-R4 中至少有一个是由-L-曲哈糖组成的侧链，其中 L 是连接分子，通过至少一个曲哈糖羟基（-OH）将曲哈糖与单体连接，其中 DG 是可生物降解基团，其中 R5 和 R6 是端基。
• Rearrangement of α-Amino Cyclopropanone Hydrate:  A Novel Route to Labeled Amino Acids
  作者：François-Xavier Felpin、Eric Doris、Alain Wagner、Alain Valleix、Bernard Rousseau、Charles Mioskowski

  DOI：10.1021/jo001126h

  日期：2001.1.1
• Homopolymers and Random Copolymers of 5,6-Benzo-2-methylene-1,3-dioxepane and Methyl Methacrylate:  Structural Characterization Using 1D and 2D NMR
  作者：Holger Wickel、Seema Agarwal、Andreas Greiner

  DOI：10.1021/ma025983u

  日期：2003.4.1

  Complete structural characterization of 5,6-benzo-2-methylene-1,3-dioxepane (BMDO) monomer and its homopolymer is carried out using 1D and 2D NMR techniques. Copolymers of BMDO were made with MMA under ATRP reaction conditions. The copolymer compositions were obtained from H-1 NMR spectroscopy. The reactivity ratios for the copolymerization of BMDO with MMA were determined using the Kelen-Tud (o) over bars method and was found to be r(BMDO) = 0.53 and r(MMA) = 1.96. Compositional and configurational sequence analysis of copolymers is also done.