α-Chloroisobutyrophenone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: α-Chloroisobutyrophenone
• 英文别名: 3-chloro-2-methyl-1-phenylpropan-1-one；β-Chlor-α-methyl-propiophenon；3-Chlor-2-methyl-1-phenyl-propan-1-on；3-Chloro-2-methylpropiophenone
• 化学式: C₁₀H₁₁ClO
• 分子量: 182.65
• InChiKey: VAMAAKQTBVOJPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  α-Chloroisobutyrophenone 在 喹啉 作用下， 生成 2-甲基-1-苯基-丙-2-烯-1-酮
  参考文献：
  名称：

  Tilitschenko; Popowa, Zhurnal Obshchei Khimii, 1953, vol. 23, p. 118,120; engl. Ausg. S. 115

  摘要：

  DOI：
• 作为产物：
  描述：

  异丁酰苯 在 磺酰氯 作用下， 反应 3.0h， 以67%的产率得到α-Chloroisobutyrophenone
  参考文献：
  名称：

  长程三重态氢提取。β-芳基苯丙酮光化学形成 2-四氢萘酚

  摘要：

  Par photocyclisation de β-aryl propiophenones, on obtient des trimethyl-,dimethyl-etmethyl phenyl-2 tetrahydro-1,2,3,4naphtols-2

  DOI：

  10.1021/ja00199a045

文献信息

• Catalytic Ring Expansion of Vinyl Oxetanes: Asymmetric Synthesis of Dihydropyrans Using Chiral Counterion Catalysis
  作者：Boying Guo、Gregg Schwarzwalder、Jon T. Njardarson

  DOI：10.1002/anie.201201367

  日期：2012.6.4

  Acid Showdown! The first catalytic ring expansion of vinyl oxetanes to 3,6‐dihydro‐2H‐pyrans is described. Copper(II) triflate emerged as the best catalyst for this new transformation, which has broad scope as demonstrated by the eighteen examples included. The symmetric vinyl oxetane substrate can be asymmetrically desymmetrized when using either chiral Lewis or Brønsted acids as catalysts.

  酸对决！描述了乙烯基氧杂环丁烷向3,6-dihydro-2 H-吡喃的第一个催化环扩展。三氟甲磺酸铜（II）成为该新转化的最佳催化剂，其范围广泛，如18个实例所示。当使用手性路易斯酸或布朗斯台德酸作为催化剂时，对称乙烯基氧杂环丁烷底物可以不对称脱对称。
• Visible-Light-Mediated Rose Bengal-Catalyzed α-Hydroxymethylation of Ketones with Methanol
  作者：Jingya Yang、Dongtai Xie、Hongyan Zhou、Shuwen Chen、Jiaokui Duan、Congde Huo、Zheng Li

  DOI：10.1002/adsc.201800467

  日期：2018.9.17

  A visible‐light‐mediated α‐hydroxymethylation of ketones using methanol as the hydroxymethylating reagent has been developed. Using 1 mol% rose bengal as the photosensitizer and air as the green oxidant, the reactions proceeded smoothly at room temperature. Experimental studies indicate the reaction proceeded via a radical pathway.

  已经开发出使用甲醇作为羟甲基化试剂的酮的可见光介导的α-羟甲基化方法。使用1mol％的孟加拉红作为光敏剂，并使用空气作为绿色氧化剂，该反应在室温下顺利进行。实验研究表明反应是通过自由基途径进行的。
• The Reaction of Acyl Halides with Cyclopropane
  作者：Harold Hart、Omer E. Curtis

  DOI：10.1021/ja01561a042

  日期：1957.2
• PHENACYLAMINE DERIVATIVES, PRODUCTION THEREOF AND PEST CONTROLLERS CONTAINING THE DERIVATIVES
  申请人：ISHIHARA SANGYO KAISHA, LTD.

  公开号：EP1256569B1

  公开（公告）日：2010-07-07
• Phenacylamin derivatives, production thereof and pest controllers containing the derivatives
  申请人：——

  公开号：US20030153464A1

  公开（公告）日：2003-08-14

  The present invention relates to a phenacylamine derivative of the formula (I) or a salt thereof: 1 wherein A is alkyl, cycloalkyl, phenyl which may be substituted by Y, pyridyl which may be substituted by Y, or pyrazolyl which may be substituted by Y, R 1 and R 2 are each alkyl, or R 1 and R 2 may together form a 3- to 6-membered saturated carbocycle, R 3 is hydrogen, alkyl, alkoxyalkyl, alkylthioalkyl or COR 4 , X is halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, alkenyloxy, haloalkenyloxy, alkynyloxy, haloalkynyloxy, alkylthio, haloalkylthio, alkenylthio, haloalkenylthio, alkynylthio, haloalkynylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, dialkylaminosulfonyl, nitro, cyano, phenyl which may be substituted by Y, phenoxy which may be substituted by Y, benzyloxy which may be substituted by Y, or pyridyloxy which may be substituted by Y, and n is an integer of from 0 to 5.