1,4-anhydro-2,3,5-tri-O-methyl-D-rybitol | 81938-60-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,4-anhydro-2,3,5-tri-O-methyl-D-rybitol
• 英文别名: 1,4-Anhydro-2,3,5-tri-O-methyl-D-ribitol；(2R,3S,4S)-3,4-dimethoxy-2-(methoxymethyl)oxolane
• CAS: 81938-60-5
• 化学式: C₈H₁₆O₄
• 分子量: 176.213
• InChiKey: PFPWLRZFWHVNMO-RNJXMRFFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methyl 2,3,5-tri-O-methyl-β-D-ribofuranoside 在 三乙基硅烷 、 三氟化硼乙醚 作用下， 以 三氟乙酸 为溶剂， 以95%的产率得到1,4-anhydro-2,3,5-tri-O-methyl-D-rybitol
  参考文献：
  名称：

  Reductive cleavage of glycosides

  摘要：

  DOI：

  10.1021/ja00376a065

文献信息

• S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS
  申请人：Aligos Therapeutics, Inc.

  公开号：US20210189392A1

  公开（公告）日：2021-06-24

  Various embodiments provide STOPS™ polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS™ modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS™ modified oligonucleotides, as determined by HBsAg Secretion Assay, is an EC 50 that is less than 100 nM.
• Reductive cleavage of glycosides
  作者：David Rolf、Gary R. Gray

  DOI：10.1021/ja00376a065

  日期：1982.6