4-(6-methylpyridin-3-yl)thiazol-2-amine | 1101174-24-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(6-methylpyridin-3-yl)thiazol-2-amine
• 英文别名: 4-(6-methylpyridin-3-yl)-1,3-thiazol-2-amine
• CAS: 1101174-24-6
• 化学式: C₉H₉N₃S
• 分子量: 191.257
• InChiKey: NAFKXHMLGSTKAQ-UHFFFAOYSA-N

物化性质

• 沸点：
  384.2±27.0 °C(Predicted)
• 密度：
  1.281±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  80
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-甲基烟酸甲酯 、 氯碘甲烷 、 硫脲 在 lithium diisopropyl amide 、 sodium acetate 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 1.75h， 生成 4-(6-methylpyridin-3-yl)thiazol-2-amine
  参考文献：
  名称：

  [EN] DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR
  [FR] DÉRIVÉS DE L'URÉE ET DE DIAMINES ASSOCIÉES, LEURS PROCÉDÉS DE FABRICATION, ET LEURS UTILISATIONS

  摘要：

  公开号：

  WO2009009122A3

文献信息

• Derivatives of urea and related diamines, methods for their manufacture, and uses therefor
  申请人：Deprez Pierre

  公开号：US20090054463A1

  公开（公告）日：2009-02-26

  The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes.

  本发明一般涉及代表式I的化合物、包含它们的药物组合物以及治疗与钙感受受体功能相关的疾病或障碍的方法。本发明还涉及制备此类化合物的方法以及在这些过程中有用的中间体。
• SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES
  申请人：Masarykova univerzita

  公开号：EP3556755A1

  公开（公告）日：2019-10-23

  The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

  本发明提供了结构式（1）所代表的化合物： 其中 R1、R2、R3、R4、R5、R6 如权利要求中定义。这些化合物是核酸酶的抑制剂，特别适用于增殖性疾病、神经退行性疾病和其他基因组不稳定性相关疾病的治疗和/或预防方法。
• DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR
  申请人：Amgen Inc.

  公开号：EP2176247A2

  公开（公告）日：2010-04-21
• 6, 11-BRIDGED BIARYL MACROLIDES
  申请人：Enanta Pharmaceuticals, Inc.

  公开号：EP2203435B1

  公开（公告）日：2018-07-18
• 6,11-BRIDGED BIARYL MACROLIDES
  申请人：KIM IN JONG

  公开号：US20090118506A1

  公开（公告）日：2009-05-07

  The present invention discloses compounds of formula I, II or, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.