2-(1,3-dioxolan-2-yl)-1-(4-methoxyphenyl)ethanone | 108323-51-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(1,3-dioxolan-2-yl)-1-(4-methoxyphenyl)ethanone
• 英文别名: 2-[1,3]dioxolan-2-yl-1-(4-methoxy-phenyl)-ethanone；2-[1,3]Dioxolan-2-yl-1-(4-methoxy-phenyl)-aethanon
• CAS: 108323-51-9
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: JHGMJQJHLOMJGE-UHFFFAOYSA-N

物化性质

• 沸点：
  368.8±22.0 °C(Predicted)
• 密度：
  1.158±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-chloro-1-(4-methoxy-phenyl)-propenone 、 乙二醇 在 氢氧化钾 作用下， 生成 2-(1,3-dioxolan-2-yl)-1-(4-methoxyphenyl)ethanone
  参考文献：
  名称：

  Kotscheschkow et al., Zhurnal Obshchei Khimii, 1959, vol. 29, p. 2570,2574; engl. Ausg. S. 2533, 2536

  摘要：

  DOI：

文献信息

• Regioselective Oxyalkylation of Vinylarenes Catalyzed by Diatomite-Supported Manganese Oxide Nanoparticles
  作者：Huayin Sun、Yonghui Zhang、Fengfeng Guo、Zhenggen Zha、Zhiyong Wang

  DOI：10.1021/jo2026367

  日期：2012.4.6

  A regioselective oxyalkylation reaction of vinylarenes with cyclic ethers was developed under the catalysis of a new heterogeneous catalyst, the diatomite-supported Mn3O4 nanoparticles (SMONP-1). The use of this heterogeneous catalyst provided a novel approach for the synthesis of alpha-carbonyled beta-alkylated aryl derivatives via a sp(3) C-H bond functionalization under mild aerobic conditions.
• CuBr-Mediated Oxyalkylation of Vinylarenes under Aerobic Conditions via Cleavage of sp³ C−H Bonds α to Oxygen
  作者：Kai Cheng、Lehao Huang、Yuhong Zhang

  DOI：10.1021/ol900947d

  日期：2009.7.2

  A novel difunctionalization reaction of vinylarenes with cyclic ethers has been developed by copper catalysis via direct activation of alpha-sp(3) C-H bonds of oxygen in the presence of 1-1.2 equiv of TBHP under mild aerobic conditions. The reaction shows excellent regioselectivities and good functional group tolerance to give the oxyalkylated products of vinylarenes.