(3-bromo-4-hydroxyphenyl)acetamide | 29121-26-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-bromo-4-hydroxyphenyl)acetamide
• 英文别名: 2-bromo-p-acetamidophenol；3-bromo-4-hydroxy-phenylacetamide；3-Bromo-4-hydroxybenzeneacetamide；2-(3-bromo-4-hydroxyphenyl)acetamide
• CAS: 29121-26-4
• 化学式: C₈H₈BrNO₂
• 分子量: 230.061
• InChiKey: BVTCJCWLWJMGCG-UHFFFAOYSA-N

物化性质

• 沸点：
  415.2±35.0 °C(Predicted)
• 密度：
  1.671±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3-bromo-4-hydroxyphenyl)acetamide 以 高氯酸 为溶剂， 以25%的产率得到2-(3-Bromo-1-hydroxy-4-oxo-cyclohexa-2,5-dienyl)-acetamide
  参考文献：
  名称：

  Halogenatedp-quinols of marine sponges. Synthesis via anodic oxidation of phenols and NHI-like rearrangement

  摘要：

  Oxidation of either 2,6-dibromo- (1), 2-bromo- (3), or 2-bromo-6-chloro-p-acetamidophenol (5) at a Pt anode in aq. HClO4 affords the corresponding common, 2, or rare, 4 and 6, marine halo-p-quinols in practicable yields, whereas literature recipes as to either chemical or electrochemical oxidations proved to be ineffective; these halo-p-quinols proved to be extremely alkali-labile, in part due to a NHI-like rearrangement.

  DOI：

  10.1016/0040-4039(91)80622-d
• 作为产物：
  描述：

  2-(3-溴-4-羟基苯基)乙酸乙酯 在 ammonium hydroxide 作用下， 生成 (3-bromo-4-hydroxyphenyl)acetamide
  参考文献：
  名称：

  DE2007751

  摘要：

  公开号：

文献信息

• [EN] 2-'5-(5-CARBAMIMIDOYL-1H-HETEROARYL)-6-HYDROXYBIPHENYL-3-YL!- CARBOXYLIC ACID DERIVATIVES AS FACTOR VIIA INHIBITORS<br/>[FR] DERIVES D'ACIDE 2[-5-(5-CARBAMIMIDOYL-1H-HETEROARYL)-6-HYDROXYBIPHENYL-3-YL] CARBOXYLIQUE COMME INHIBITEURS DU FACTEUR VIIA
  申请人：AXYS PHARM INC

  公开号：WO2004062661A1

  公开（公告）日：2004-07-29

  The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders. Processes for preparing these inhibitors are also disclosed.

  本发明涉及新型因子VIIa、IXa、Xa、XIa的抑制剂，特别是因子VIIa，包括这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病的方法。还公开了制备这些抑制剂的方法。
• Novel, racemic or nearly-racemic antibacterial bromo- and chloroquinols and ?-lactams of the verongiaquinol and the cavernicolin type from the marine spongeAplysina (=Verongia)cavernicola
  作者：Michele D'Ambrosio、Antonio Guerriero、Francesco Pietra

  DOI：10.1002/hlca.19840670610

  日期：1984.9.26

  Both 1 and 1c proved to be racemic from NMR examination of their esterification products with (–)-methyl-oxyacetic acid, whilst 6 had a ca. 6% enantiomeric purity as shown by a 1H-NMR study of its monoacetate 6′ in the presence of a chiral shift reagent. These chiroptical data of the first chiral quinols from the Verongida and of 6 suggest phenol oxidative routes from tyrosine precursors for their formation

  地中海海绵的丁醇提取物Aplysina（= Verongia）cavernicola给，通过反相HPLC，抗菌quinols（±）-3- bromoverongiaquinol（=（±）-3-溴-1-羟基-4-氧代-2- ，5-环己基-1-乙酰胺；1d）和（±）-3-溴-5-氯verongiaquinol（=（±）-3-溴-5-氯-1-羟基-4-氧代-2,5-环己氨酸-1-乙酰胺；1c）除其正式环化的产物5-氯己二烯-1-乙酰胺外；1c）除了其正式环化的产物5-氯曲霉素（= 5-cloro-3,3a，7,7aβ-tetrahydro-3aβ-hydroxy-2,6（1 H）-indoledione; 6），C（7）-致敏的7β-溴-5-氯卡维尼可林（= 7β-溴-5-氯-3,3a，7,7aβ-四氢-3aβ-羟基-2,6（1H）-吲哚二酮; 4a和7α-bromo-5- chlorocavernicolin
• Benzimidazole derivative, a method for producing the same, its intermediate compounds and an agricultural and horticultural fungicide containing the benzimidazole derivative as an active ingredient
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0487286A1

  公开（公告）日：1992-05-27

  A benzimidazole derivative having the formula, wherein X is halogen, is produced by reacting a compound having the formula, wherein X is halogen, with dimethylsulfamoyl chloride. The benzimidazole derivative can be used as an active ingredient in agricultural and horticultural fungicides.

  具有以下式子的苯并咪唑衍生物 式中 X 为卤素的苯并咪唑衍生物，是由具有以下式子的化合物反应生成的、 式中 X 为卤素的化合物与二甲基氨基磺酰氯反应制得。 苯并咪唑衍生物可用作农用和园艺杀菌剂的活性成分。
• US5234938A
  申请人：——

  公开号：US5234938A

  公开（公告）日：1993-08-10