GL5 在
N-苯基马来酰亚胺 作用下,
以
various solvent(s) 为溶剂,
以65%的产率得到3-(2-methylthio-5-methyl-3-thienyl)-N-phenyl-2-isothiazoline-4,5-dicarboximide
参考文献:
名称:
Synthesis of 3-thienyl-substituted isothiazolines-2 and 1,2,4-thiadiazoles based on nitrile sulfides of the thiophene series
摘要:
The reaction of substituted alpha- and beta-thienylcarboxamides with chlorocarbonylsulfenyl chloride gave 5-thienyl-substituted 1,3,4-oxathiazol-2-ones. Decarboxylation of the latter by heating in o-dichlorobenzene generated in situ alpha- and beta-thienylnitrile sulfides, which in the presence of dipolarophiles [dimethyl fumarate, N-phenylmaleinimide, chloro(trichloro)acetonitrile] give the corresponding 3-thienyl-substituted DELTA2-isothiazolines and 5-chloromethyl(trichloromethyl)-1,2,4-thiadiazoles.
Synthesis of 3-thienyl-substituted isothiazolines-2 and 1,2,4-thiadiazoles based on nitrile sulfides of the thiophene series
摘要:
The reaction of substituted alpha- and beta-thienylcarboxamides with chlorocarbonylsulfenyl chloride gave 5-thienyl-substituted 1,3,4-oxathiazol-2-ones. Decarboxylation of the latter by heating in o-dichlorobenzene generated in situ alpha- and beta-thienylnitrile sulfides, which in the presence of dipolarophiles [dimethyl fumarate, N-phenylmaleinimide, chloro(trichloro)acetonitrile] give the corresponding 3-thienyl-substituted DELTA2-isothiazolines and 5-chloromethyl(trichloromethyl)-1,2,4-thiadiazoles.
PROTEASOME INHIBITORS AND THEIR USE IN TREATING PATHOGEN INFECTION AND CANCER
申请人:Nathan Carl
公开号:US20110118274A1
公开(公告)日:2011-05-19
The present invention relates to proteasome inhibitors and their use in methods of treating a subject for a pathogen infection or cancer. The methods involve administering to the subject a compound of Formula (I). (I) where: Q is Formula or Formula, where the crossing dashed line illustrates the bond formed joining Q to the rest of the compound of Formula (I). The remainder of substituents of the compound of Formula (I) are defined in the present application.
[EN] PROTEASOME INHIBITORS AND THEIR USE IN TREATING PATHOGEN INFECTION AND CANCER<br/>[FR] INHIBITEURS DE PROTÉASOME ET LEUR UTILISATION DANS LE TRAITEMENT D'UNE AFFECTION PATHOGÈNE ET DU CANCER
申请人:CORNELL RES FOUNDATION INC
公开号:WO2009026579A1
公开(公告)日:2009-02-26
The present invention relates to proteasome inhibitors and their use in methods of treating a subject for a pathogen infection or cancer. The methods involve administering to the subject a compound of Formula (I). (I) where: Q is Formula or Formula, where the crossing dashed line illustrates the bond formed joining Q to the rest of the compound of Formula (I). The remainder of substituents of the compound of Formula (I) are defined in the present application.
Synthesis of 3-thienyl-substituted isothiazolines-2 and 1,2,4-thiadiazoles based on nitrile sulfides of the thiophene series
作者:M. M. Krayushkin、M. A. Kalik、A. Ya. Kudryavtseva
DOI:10.1007/bf00864350
日期:1992.8
The reaction of substituted alpha- and beta-thienylcarboxamides with chlorocarbonylsulfenyl chloride gave 5-thienyl-substituted 1,3,4-oxathiazol-2-ones. Decarboxylation of the latter by heating in o-dichlorobenzene generated in situ alpha- and beta-thienylnitrile sulfides, which in the presence of dipolarophiles [dimethyl fumarate, N-phenylmaleinimide, chloro(trichloro)acetonitrile] give the corresponding 3-thienyl-substituted DELTA2-isothiazolines and 5-chloromethyl(trichloromethyl)-1,2,4-thiadiazoles.