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GL5 | 146304-91-8

中文名称
——
中文别名
——
英文名称
GL5
英文别名
5-(5-methyl-2-(methylthio)thiophen-3-yl)-1,3,4-oxathiazol-2-one;P1600022;5-[5-Methyl-2-(methylsulfanyl)-3-thienyl]-1,3,4-oxathiazol-2-one;5-(5-methyl-2-methylsulfanylthiophen-3-yl)-1,3,4-oxathiazol-2-one
GL5化学式
CAS
146304-91-8
化学式
C8H7NO2S3
mdl
——
分子量
245.347
InChiKey
MPAVPPZRYGYOIC-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    352.7±52.0 °C(Predicted)
  • 密度:
    1.58±0.1 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    3.1
  • 重原子数:
    14
  • 可旋转键数:
    2
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.25
  • 拓扑面积:
    118
  • 氢给体数:
    0
  • 氢受体数:
    6

反应信息

  • 作为反应物:
    描述:
    GL5N-苯基马来酰亚胺 作用下, 以 various solvent(s) 为溶剂, 以65%的产率得到3-(2-methylthio-5-methyl-3-thienyl)-N-phenyl-2-isothiazoline-4,5-dicarboximide
    参考文献:
    名称:
    Synthesis of 3-thienyl-substituted isothiazolines-2 and 1,2,4-thiadiazoles based on nitrile sulfides of the thiophene series
    摘要:
    The reaction of substituted alpha- and beta-thienylcarboxamides with chlorocarbonylsulfenyl chloride gave 5-thienyl-substituted 1,3,4-oxathiazol-2-ones. Decarboxylation of the latter by heating in o-dichlorobenzene generated in situ alpha- and beta-thienylnitrile sulfides, which in the presence of dipolarophiles [dimethyl fumarate, N-phenylmaleinimide, chloro(trichloro)acetonitrile] give the corresponding 3-thienyl-substituted DELTA2-isothiazolines and 5-chloromethyl(trichloromethyl)-1,2,4-thiadiazoles.
    DOI:
    10.1007/bf00864350
  • 作为产物:
    描述:
    5-Methyl-2-methylsulfanyl-thiophene-3-carbonyl chloride 在 作用下, 以 甲苯 为溶剂, 反应 9.0h, 生成 GL5
    参考文献:
    名称:
    Synthesis of 3-thienyl-substituted isothiazolines-2 and 1,2,4-thiadiazoles based on nitrile sulfides of the thiophene series
    摘要:
    The reaction of substituted alpha- and beta-thienylcarboxamides with chlorocarbonylsulfenyl chloride gave 5-thienyl-substituted 1,3,4-oxathiazol-2-ones. Decarboxylation of the latter by heating in o-dichlorobenzene generated in situ alpha- and beta-thienylnitrile sulfides, which in the presence of dipolarophiles [dimethyl fumarate, N-phenylmaleinimide, chloro(trichloro)acetonitrile] give the corresponding 3-thienyl-substituted DELTA2-isothiazolines and 5-chloromethyl(trichloromethyl)-1,2,4-thiadiazoles.
    DOI:
    10.1007/bf00864350
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文献信息

  • PROTEASOME INHIBITORS AND THEIR USE IN TREATING PATHOGEN INFECTION AND CANCER
    申请人:Nathan Carl
    公开号:US20110118274A1
    公开(公告)日:2011-05-19
    The present invention relates to proteasome inhibitors and their use in methods of treating a subject for a pathogen infection or cancer. The methods involve administering to the subject a compound of Formula (I). (I) where: Q is Formula or Formula, where the crossing dashed line illustrates the bond formed joining Q to the rest of the compound of Formula (I). The remainder of substituents of the compound of Formula (I) are defined in the present application.
  • [EN] PROTEASOME INHIBITORS AND THEIR USE IN TREATING PATHOGEN INFECTION AND CANCER<br/>[FR] INHIBITEURS DE PROTÉASOME ET LEUR UTILISATION DANS LE TRAITEMENT D'UNE AFFECTION PATHOGÈNE ET DU CANCER
    申请人:CORNELL RES FOUNDATION INC
    公开号:WO2009026579A1
    公开(公告)日:2009-02-26
    The present invention relates to proteasome inhibitors and their use in methods of treating a subject for a pathogen infection or cancer. The methods involve administering to the subject a compound of Formula (I). (I) where: Q is Formula or Formula, where the crossing dashed line illustrates the bond formed joining Q to the rest of the compound of Formula (I). The remainder of substituents of the compound of Formula (I) are defined in the present application.
  • Synthesis of 3-thienyl-substituted isothiazolines-2 and 1,2,4-thiadiazoles based on nitrile sulfides of the thiophene series
    作者:M. M. Krayushkin、M. A. Kalik、A. Ya. Kudryavtseva
    DOI:10.1007/bf00864350
    日期:1992.8
    The reaction of substituted alpha- and beta-thienylcarboxamides with chlorocarbonylsulfenyl chloride gave 5-thienyl-substituted 1,3,4-oxathiazol-2-ones. Decarboxylation of the latter by heating in o-dichlorobenzene generated in situ alpha- and beta-thienylnitrile sulfides, which in the presence of dipolarophiles [dimethyl fumarate, N-phenylmaleinimide, chloro(trichloro)acetonitrile] give the corresponding 3-thienyl-substituted DELTA2-isothiazolines and 5-chloromethyl(trichloromethyl)-1,2,4-thiadiazoles.
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