1-[4-(Ethoxymethoxy)-2-hydroxy-3-methylphenyl]ethanone | 942133-88-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-(Ethoxymethoxy)-2-hydroxy-3-methylphenyl]ethanone
• CAS: 942133-88-2
• 化学式: C₁₂H₁₆O₄
• 分子量: 224.257
• InChiKey: IZENGDOTBSBKKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-[4-(Ethoxymethoxy)-2-hydroxy-3-methylphenyl]ethanone 在 sodium 作用下， 以 二苯醚 为溶剂， 反应 2.0h， 生成 7-(Ethoxymethoxy)-8-methyl-4-piperazin-1-ylchromen-2-one
  参考文献：
  名称：

  Synthesis and In Vitro Antiplatelet Activity of New 4-(1-Piperazinyl)coumarin Derivatives. Human Platelet Phosphodiesterase 3 Inhibitory Properties of the Two Most Effective Compounds Described and Molecular Modeling Study on Their Interactions with Phosphodiesterase 3A Catalytic Site

  摘要：

  The synthesis and in vitro antiplatelet activity significant data of coumarin derivatives 5i-x and quinolin-2(1H)-one derivatives 22a,b, as well as the corresponding structure-activity relationships are described. The recently reported 8-methyl-4-(1-piperazinyl)-7-(3-pyridylmethoxy)coumarin 5f and its potent 7-(2-morpholinoethoxy)-substituted new analogue 5u were notably more effective inhibitors of pure human platelet PDE3 than milrinone and cilostazol: these data were related, through a molecular modeling study, with the molecular interactions of the four compounds with the human PDE3A catalytic site.

  DOI：

  10.1021/jm0611511
• 作为产物：
  描述：

  3,5-二羟基-4-乙酰甲苯 、 氯甲基乙醚 在 氢氧化钾 、 potassium carbonate 作用下， 以 丁酮 为溶剂， 反应 16.0h， 以54%的产率得到1-[4-(Ethoxymethoxy)-2-hydroxy-3-methylphenyl]ethanone
  参考文献：
  名称：

  Synthesis and In Vitro Antiplatelet Activity of New 4-(1-Piperazinyl)coumarin Derivatives. Human Platelet Phosphodiesterase 3 Inhibitory Properties of the Two Most Effective Compounds Described and Molecular Modeling Study on Their Interactions with Phosphodiesterase 3A Catalytic Site

  摘要：

  The synthesis and in vitro antiplatelet activity significant data of coumarin derivatives 5i-x and quinolin-2(1H)-one derivatives 22a,b, as well as the corresponding structure-activity relationships are described. The recently reported 8-methyl-4-(1-piperazinyl)-7-(3-pyridylmethoxy)coumarin 5f and its potent 7-(2-morpholinoethoxy)-substituted new analogue 5u were notably more effective inhibitors of pure human platelet PDE3 than milrinone and cilostazol: these data were related, through a molecular modeling study, with the molecular interactions of the four compounds with the human PDE3A catalytic site.

  DOI：

  10.1021/jm0611511

文献信息

• Synthesis and In Vitro Antiplatelet Activity of New 4-(1-Piperazinyl)coumarin Derivatives. Human Platelet Phosphodiesterase 3 Inhibitory Properties of the Two Most Effective Compounds Described and Molecular Modeling Study on Their Interactions with Phosphodiesterase 3A Catalytic Site
  作者：Giorgio Roma、Mario Di Braccio、Giancarlo Grossi、Daniela Piras、Giuliana Leoncini、Debora Bruzzese、Maria Grazia Signorello、Paola Fossa、Luisa Mosti

  DOI：10.1021/jm0611511

  日期：2007.6.1

  The synthesis and in vitro antiplatelet activity significant data of coumarin derivatives 5i-x and quinolin-2(1H)-one derivatives 22a,b, as well as the corresponding structure-activity relationships are described. The recently reported 8-methyl-4-(1-piperazinyl)-7-(3-pyridylmethoxy)coumarin 5f and its potent 7-(2-morpholinoethoxy)-substituted new analogue 5u were notably more effective inhibitors of pure human platelet PDE3 than milrinone and cilostazol: these data were related, through a molecular modeling study, with the molecular interactions of the four compounds with the human PDE3A catalytic site.