ethyl-triphenyl-urea | 20632-46-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl-triphenyl-urea
• 英文别名: Aethyl-triphenyl-harnstoff；ethyltriphenylurea；N-Aethyl-N,N',N'-triphenyl-harnstoff；N-Ethyl-N,Na(2),Na(2)-triphenylurea；1-ethyl-1,3,3-triphenylurea
• CAS: 20632-46-6
• 化学式: C₂₁H₂₀N₂O
• 分子量: 316.403
• InChiKey: RFPUVLKRDCRFPP-UHFFFAOYSA-N

物化性质

• 熔点：
  218.5-219 °C
• 沸点：
  439.0±18.0 °C(Predicted)
• 密度：
  1.171±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-乙基-N,N'-二苯基硫脲 、 二苯氨基甲酰氯 生成 ethyl-triphenyl-urea
  参考文献：
  名称：

  Dains; Roberts; Brewster, Journal of the American Chemical Society, 1916, vol. 38, p. 138

  摘要：

  DOI：

文献信息

• Michler, Chemische Berichte, 1876, vol. 9, p. 716
  作者：Michler

  DOI：——

  日期：——
• COMPARING PROSTATE SPECIFIC ANTIGEN OUTCOMES AFTER DIFFERENT TYPES OF RADIOTHERAPY MANAGEMENT OF CLINICALLY LOCALIZED PROSTATE CANCER HIGHLIGHTS THE IMPORTANCE OF CONTROLLING FOR ESTABLISHED PROGNOSTIC FACTORS
  作者：ANTHONY V. D’AMICO、DELRAY SCHULTZ、LINDSEY SCHNEIDER、MARK HURWITZ、PHILIP W. KANTOFF、JEROME P. RICHIE

  DOI：10.1016/s0022-5347(05)67546-5

  日期：2000.6

  Purpose: We evaluated the impact that the composition of prognostic factors in a patient cohort may have on prostate specific antigen (PSA) outcome following external beam radiation therapy for clinically localized prostate cancer.Materials and Methods: The distribution of PSA, biopsy Gleason score and American joint Committee on Cancer (AJCC) T stage in men with prostate cancer treated with interstitial plus external beam radiation therapy was used to select a matched cohort who underwent 3-dimensional (D) conformal external beam radiation therapy. We compared PSA outcomes after 3-D conformal external beam radiation therapy in the overall and matched cohorts of 766 and 570 patients, respectively.Results: Men treated with interstitial plus external beam radiation therapy had a significantly lower rate of PSA greater than 10 to 20 (p = 0.02) and greater than 20 ng./ml. (p <0.0001), biopsy Gleason score 7 (p = 0.02) and 8 to 10 (p <0.0001), and AJCC stage T2c disease (p <0.0001). Likewise, these men also had a significantly higher rate of PSA greater than 4 to 10 ng./ml. (p <0.0001), biopsy Gleason score 5 to 6 (p = 0.0001) and AJCC stage T1 disease (p <0.0001) than those who underwent 3-D conformal external beam radiation therapy. The 5-year estimate of PSA failure-free survival after 3-D conformal external beam radiation therapy was 45% versus 67% (p = 0.0007) for all 766 consecutively treated patients and the matched cohort of 570, respectively.Conclusions: The composition of prognostic factors in a patient cohort may impact PSA outcome. Therefore, controlling for established prognostic factors is essential when comparing PSA outcome after different forms of radiotherapy for adenocarcinoma of the prostate.
• KIM, YONG, HAE;YON, GYU, HWAN;KIM, HYUNG, JIN, CHEM. LETT., 1984, N 3, 309-312
  作者：KIM, YONG, HAE、YON, GYU, HWAN、KIM, HYUNG, JIN

  DOI：——

  日期：——
• Verfahren zur Herstellung von grobkörnigem Triaminotrinitrobenzol
  申请人：FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

  公开号：EP0056491B1

  公开（公告）日：1983-12-21
• US4439622A
  申请人：——

  公开号：US4439622A

  公开（公告）日：1984-03-27